Sandy studies the molecular mechanisms underlying netrin-mediated axon guidance and circuitry formation during nervous system development.
Raquel’s research focuses on the mechanobiology of vascular endothelial homeostasis and repair.
NOTCH1 is a mechanosensor in adult arteries. Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Guido FC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Ku CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017;8(1):1620.
McDonald, A.I., Shirali, A.S., Aragón, R., Ma, F., Hernandez, G., Vaughn, D.A., Mack, J.J., Lim, T.Y., Sunshine, H., Zhao, P., Kalinichenko, V., Pelegrini, M., Ardehali, R., and Iruela-Arispe, M.L. 2018. Endothelial Regeneration of Large Vessels is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities. Cell Stem Stell. 23(2):210-225.
Min studies function of small molecules in lifespan extension and aging related diseases.
T cell development
Fangtao is currently interested in the metabolic control of early mouse development.
Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation. Nagaraj R, Sharpley MS, Chi F, Braas D, Zhou Y, Kim R, Clark AT, Banerjee U. Cell. 2017 Jan 12;168(1-2):210-223.e11. doi: 10.1016/j.cell.2016.12.026. Epub 2017 Jan 12.
Tsotne’s research focuses on Long non-coding RNA, XIST mediated molecular mechanisms of X chromosome regulation in human embryonic development. We study this epigenetic event in human pluripotent stem cells and human primordial germ cells.
Preston is characterizing metabolism in prostate progenitor cells and tumorigenesis.
Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer. Crowell PD, Goldstein AS. Mol Cell Oncol. 2017 Jan 13;4(2):e1279723. doi: 10.1080/23723556.2017.1279723. eCollection 2017.
Michael is interested in developing genetic therapeutic strategies for Duchenne muscular dystrophy (DMD).
In the Jones lab, Adam is investigating the function of tricellular junction proteins in age-related intestinal barrier maintenance and regulation.
Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Resende LP, Truong ME, Gomez A, Jones DL. Dev Biol. 2017 Apr 1;424(1):10-17. doi: 10.1016/j.ydbio.2017.01.004. Epub 2017 Jan 17.
A Drought-Inducible Transcription Factor Delays Reproductive Timing in Rice. Zhang C, Liu J, Zhao T, Gomez A, Li C, Yu C, Li H, Lin J, Yang Y, Liu B, Lin C. Plant Physiol. 2016 May;171(1):334-43. doi: 10.1104/pp.16.01691. Epub 2016 Mar 4.
Grace researches the origin of human germ cells and their molecular specifiers during early development.
Gloria studies the molecular regulation of angiogenesis and vascular homeostasis.
Elena studies molecular etiology to link mutations to neuronal dysfunction in intellectual disability syndromes.
Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. Ohashi, M, Korsakova, E, Allen, D, Lee, P, Fu, K, Vargas, BS, Cinkornpumin, J, Salas, C, Park, JC, Germanguz, I, Langerman, J, Chronis, C, Kuoy, E, Tran, S, Xiao, X, Pellegrini, M, Plath, K, Lowry, WE. Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. Stem Cell Reports. 2018; 10(5): 1453-1463.
Josh Zixi Lee
Josh’s research is centered around the role of alternative splicing and lncRNAs in heart development and disease.
Skott Lee (Ha Neul)
Skott is defining the mechanistic basis for the effect of RECK alternative polyadenylation on cell migration and invasion.
RECK isoforms have opposing effects on cell migration. Lee HN, Mitra M, Bosompra O, Corney DC, Johnson EL, Rashed N, Ho LD, Coller HA. Mol Biol Cell. 2018 Jun 6: mbcE17120708. doi: 10.1091/mbc. E17-12-0708. [Epub ahead of print]
Yanjing is studying the tumorigenesis of castration-resistant prostate cancer.
Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D, Koehler CM, Graeber TG, Chiou PY, Teitell MA. Cell Metab. 2016 May 10;23(5):921-9. doi: 10.1016/j.cmet.2016.04.007.
Huachun studies cryptochrome, which is a blue light photo-receptor in Arabidopsis.
Matthew is investigating the maturation of germ cell progenitors.
Feiyang is focusing on developing single cell RNA sequencing methods and subsequent data analysis.
Matilde is investigating the role of metabolism in hair follicle stem cell homeostasis and its role during epidermal aging.
Lactate dehydrogenase activity drives hair follicle stem cell activation – Flores A, Schell J, Krall AS, Jelinek D, Miranda MM, Grigorian M, Lowry WE. . Nature Cell Biology 2017 doi:10.1038/ncb3575
Topical inhibition of the electron transport chain can stimulate the hair cycle – Miranda MM, Christofk H, Jones DL, Lowry WE. Journal of Investigative Dermatology 2017. https://doi.org/10.1016/j.jid.2017.10.021
Matt is using iPSCs and viruses to investigate gene therapy strategies for congenital liver metabolism disorders.
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice – Stephanie A.K. Angarita, Brian Truong, Suhail Khoja, Matthew Nitzahn, Abha K. Rajbhandari, Irina Zhuravka, Sergio Duarte, Michael G. Lin, Alex K. Lam, Stephen D. Cederbaum, Gerald S Lipshutz. Molecular Genetics and Metabolism 2018 https://doi.org/10.1016/j.ymgme.2018.04.005
Conditional Disruption of Hepatic Carbamyl Phosphate Synthetase 1 in Mice Results in Hyperammonemia without Orotic Aciduria – Suhail Khoja, Matthew Nitzahn, Kip Hermann, Brian Truong, Roberta Borzone, Brandon Willis, Mitchell Rudd, Donna J. Palmer, Philip Ng, Nicola Brunetti-Pierri, Gerald S. Lipshutz. Molecular Genetics and Metabolism 2018 https://doi.org/10.1016/j.ymgme.2018.04.005
Poster presenter at the 21st annual conference for the American Society of Gene and Cell Therapy. “Split AAV-Mediated Gene Addition Therapy for Carbamoyl Phosphate Synthetase 1 Deficiency.”
Jessica is examining the physiological roles of a protein called Diet1 in the mouse model organism. A lack of Diet1 has previously been shown to make mice less susceptible to hypercholesterolemia when put on an atherogenic diet due to an enhanced bile acid secretion phenotype.
Hmga2 is dispensable for cutaneous squamous cell carcinoma. White A, Flores A, Ong J, Lowry WE. Exp Dermatol. 2016 May;25(5):409-12. doi: 10.1111/exd.12978
Cynthia is using genetic and pharmacological approaches to target Sarcospan in Duchenne Muscular Dystrophy.
Yang is interested in activity dependent transfer of RNAs via extracellular vesicles(EVs) and how EVs contribute to neuronal synaptic plasticity.
Aaron Van Loon
Aaron is determining the structure and mechanism of epithelial microridge development in zebrafish.
Anastasia studies transcription factors governing hematopoietic stem cell proliferation, self-renewal, and differentiation.
Yurun studies the effects of PTPRS inhibition in hematopoietic stem cells.
Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP. Cell Rep. 2016 Nov 1;17(6):1584-1594. doi: 10.1016/j.celrep.2016.10.025.
A Small Molecule Inhibitor of Protein Tyrosine Phosphatase-Sigma (PTPσ) Promotes Hematopoietic Stem Cell (HSC) Regeneration. Zhang, Y., Quarmyne, M., Himburg, H. A., Yan, X., McBride, W., Jung, M., & Chute, J. P. Blood 128, no. 22 (2016): 822.