CDB Current Students

Sandy Alvarez

Mentor: Samantha Butler

Research Project:

Sandy studies the molecular mechanisms underlying netrin-mediated axon guidance and circuitry formation during nervous system development.

Sharraya Aschemeyer

Mentor: Tomas Ganz

Research project:

Sharraya’s current research focuses on the mechanism by which intracellular iron stores increase hepcidin. She is also interested in understanding the details of hepcidin-mediated ferroportin endocytosis.

Publications:

Erythroferrone and matriptase-2 independently regulate hepcidin expression. Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L.

Am J Hematol. 2017 May;92(5):E61-E63. doi: 10.1002/ajh.24672. Epub 2017 Feb 24. No abstract available.

Min Chai

Mentor: Jing Huang

Research project:

Min studies function of small molecules in lifespan extension and aging related diseases.

Patrick Chang

Mentor: Gay Crooks

Research project:

T cell development

Fangtao Chi

Mentor: Utpal Banerjee
Research project:

Fangtao is currently interested in the metabolic control of early mouse development.

Publications:

Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation. Nagaraj R, Sharpley MS, Chi F, Braas D, Zhou Y, Kim R, Clark AT, Banerjee U. Cell. 2017 Jan 12;168(1-2):210-223.e11. doi: 10.1016/j.cell.2016.12.026. Epub 2017 Jan 12.

Tsotne Chitiashvili

Mentor: Kathrin Plath and Amander Clark

Research project:

Tsotne’s research focuses on Long non-coding RNA, XIST mediated molecular mechanisms of X chromosome regulation in human embryonic development. We study this epigenetic event in human pluripotent stem cells and human primordial germ cells. 

Preston Crowell

Mentor: Andrew Goldstein

Research project:

Preston is characterizing metabolism in prostate progenitor cells and tumorigenesis.

Publications:

Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer. Crowell PD, Goldstein AS. Mol Cell Oncol. 2017 Jan 13;4(2):e1279723. doi: 10.1080/23723556.2017.1279723. eCollection 2017.

Michael Emami

Mentor: Melissa Spencer

Research Project:

Michael is interested in developing genetic therapeutic strategies for Duchenne muscular dystrophy (DMD).

Aimee Flores

Mentor: Bill Lowry
Research project:

Using the hair follicle as a model system for tumorigenesis with a stem cell origin, Aimee is exploring the role of metabolism in tissue homeostasis and tumor intitiation by hair follicle stem cells.

Publications:

Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma. Lowry WE, Flores A, White AC. J Invest Dermatol. 2016 May 7. pii: S0022-202X(16)30978-2. doi: 10.1016/j.jid.2016.03.017. [Epub ahead of print] Review.

Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma. Flores A, Grant W, White AC, Scumpia P, Takahashi R, Lowry WE. Exp Dermatol. 2016 Apr 20. doi: 10.1111/exd.13037.

Hmga2 is dispensable for cutaneous squamous cell carcinoma. White A, Flores A, Ong J, Lowry WE. Exp Dermatol. 2016 May;25(5):409-12. doi: 10.1111/exd.12978.

The NADPH-Production Enzyme Isocitrate Dehydrogenase Maintains Quiescence in Hair Follicle Stem Cells. Ambrus, AM., Lemons, J., Raitman, I., Krishnan, N., Jelinek, D., Suh, E., Remillard M., Shilo, L., Xiao, R., Flores, A., Wang, D., White, A., Lowry, W., Coller, H. FASEB J. April 2016 20:1260.5.

Adam Gomez

Mentor: Leanne Jones
Research project:

In the Jones lab, Adam is investigating the function of tricellular junction proteins in age-related intestinal barrier maintenance and regulation.

Publications:

Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Resende LP, Truong ME, Gomez A, Jones DL. Dev Biol. 2017 Apr 1;424(1):10-17. doi: 10.1016/j.ydbio.2017.01.004. Epub 2017 Jan 17.

A Drought-Inducible Transcription Factor Delays Reproductive Timing in Rice. Zhang C, Liu J, Zhao T, Gomez A, Li C, Yu C, Li H, Lin J, Yang Y, Liu B, Lin C. Plant Physiol. 2016 May;171(1):334-43. doi: 10.1104/pp.16.01691. Epub 2016 Mar 4.

Grace Hancock

Mentor: Amander Clark

Research Project:

Grace researches the origin of human germ cells and their molecular specifiers during early development.

Gloria Hernandez

Mentor: Luisa Iruela-Arispe

Research project:

Gloria studies the molecular regulation of angiogenesis and vascular homeostasis.

Raquel Hernandez-Solis

Mentor: Luisa Iruela-Arispe

Research Project:

Raquel’s research focuses on the mechanobiology of vascular endothelial homeostasis and repair.

Arthur Ko

Mentor: Paivi Pajukanta
Research project:

His current research focuses integration of genomics, transcriptomics and functional approaches to understand cardiovascular disease pathogenesis in admixed populations.

Publications:

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stančáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T, Collins FS, Gargalovic PS, Boehnke M, Laakso M, Mohlke KL, Lusis AJ. Am J Hum Genet. 2017 Mar 2;100(3):428-443. doi: 10.1016/j.ajhg.2017.01.027.

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene. Rodríguez A, Gonzalez L, Ko A, Alvarez M, Miao Z, Bhagat Y, Nikkola E, Cruz-Bautista I, Arellano-Campos O, Muñoz-Hernández LL, Ordóñez-Sánchez ML, Rodriguez-Guillen R, Mohlke KL, Laakso M, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1350-5. doi: 10.1161/ATVBAHA.116.307182. Epub 2016 May 19.

Integrative approaches for large-scale transcriptome-wide association studies. Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B. Nat Genet. 2016 Mar;48(3):245-52. doi: 10.1038/ng.3506. Epub 2016 Feb 8.

Remote Ischemic Conditioning Alters Methylation and Expression of Cell Cycle Genes in Aneurysmal Subarachnoid Hemorrhage. Nikkola E, Laiwalla A, Ko A, Alvarez M, Connolly M, Ooi YC, Hsu W, Bui A, Pajukanta P, Gonzalez NR. Stroke. 2015 Sep;46(9):2445-51. doi: 10.1161/STROKEAHA.115.009618. Epub 2015 Aug 6.

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PM, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC, Arellano-Campos O, Muñoz-Hernández LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliövaara M, Raitakari O, Lehtimäki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen MR, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P. Nat Commun. 2014 Jun 2;5:3983. doi: 10.1038/ncomms4983.

Elena Korsakova

Mentor: Bill Lowry

Research Project:

Elena studies molecular etiology to link mutations to neuronal dysfunction in intellectual disability syndromes.

Josh Zixi Lee

Mentor: Yibin Wang
Research project:

Josh’s research is centered around the role of alternative splicing and lncRNAs in heart development and disease.

Skott Lee (Ha Neul)

Mentor: Hillary Coller

Research project:

Skott is defining the mechanistic basis for the effect of RECK alternative polyadenylation on cell migration and invasion.

Sophia Lewis

Mentor: Leanne Jones
Research project:

Sophia is interested in the impact of aging on intestinal stem cell homeostasis.

Publications:

Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Resnik-Docampo M, Koehler CL, Clark RI, Schinaman JM, Sauer V, Wong DM, Lewis S, D’Alterio C, Walker DW, Jones DL. Nat Cell Biol. 2017 Jan;19(1):52-59. doi: 10.1038/ncb3454. Epub 2016 Dec 19.

Yanjing Li

Mentor: Lily Wu
Research project:

Yanjing is studying the tumorigenesis of castration-resistant prostate cancer.

Publications:

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D, Koehler CM, Graeber TG, Chiou PY, Teitell MA. Cell Metab. 2016 May 10;23(5):921-9. doi: 10.1016/j.cmet.2016.04.007.

Serum lipid profiles and aggressive prostate cancer. Li Y, Liang C, Huang J. Asian J Androl. 2015 Mar-Apr;17(2):336. doi: 10.4103/1008-682X.143308

Ying Lin

Mentor: Larry Zipursky

Huachun Liu

Mentor: Chentao Lin

Research project:

Huachun studies cryptochrome, which is a blue light photo-receptor in Arabidopsis.

Wanlu Liu

Mentor: Steve Jacobsen
Research project:

Wanlu is interested in studying DNA methylation in the model plant Arabidopsis thaliana with next generation sequencing techniques.

Publications:

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. Clark AT, Gkountela S, Chen D, Liu W, Sosa E, Sukhwani M, Hennebold JD, Orwig KE. Stem Cell Reports. 2017 Jul 11;9(1):329-341. doi: 10.1016/j.stemcr.2017.05.002. Epub 2017 Jun 1.

DNA methylome of the 20-gigabase Norway spruce genome. Ausin I, Feng S, Yu C, Liu W, Kuo HY, Jacobsen EL, Zhai J, Gallego-Bartolome J, Wang L, Egertsdotter U, Street NR, Jacobsen SE, Wang H. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8106-E8113. Epub 2016 Nov 28.

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Li S, Yen L, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ, Jacobsen SE. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5108-16. doi: 10.1073/pnas.1609709113. Epub 2016 Aug 15.

Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes. Harris CJ, Husmann D, Liu W, Kasmi FE, Wang H, Papikian A, Pastor WA, Moissiard G, Vashisht AA, Dangl JL, Wohlschlegel JA, Jacobsen SE. PLoS Genet. 2016 May 12;12(5):e1005998. doi: 10.1371/journal.pgen.1005998. eCollection 2016 May

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory. Pastor WA*, Chen D*, Liu W*, Kim R, Sahakyan A, Lukianchikov A, Plath K, Jacobsen SE, Clark AT. Cell Stem Cell. 2016 Mar 3;18(3):323-9. doi: 10.1016/j.stem.2016.01.019. Epub 2016 Feb 4.

A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis. Zhai J, Bischof S, Wang H, Feng S, Lee TF, Teng C, Chen X, Park SY, Liu L, Gallego-Bartolome J, Liu W, Henderson IR, Meyers BC, Ausin I, Jacobsen SE. Cell. 2015 Oct 8;163(2):445-55. doi: 10.1016/j.cell.2015.09.032.

MORC1 represses transposable elements in the mouse male germline. Pastor WA, Stroud H, Nee K, Liu W, Pezic D, Manakov S, Lee SA, Moissiard G, Zamudio N, Bourc’his D, Aravin AA, Clark AT, Jacobsen SE. Nat Commun. 2014 Dec 12;5:5795. doi: 10.1038/ncomms6795. Erratum in: Nat Commun. 2015;6:7604.

 

Matthew Lowe

Mentor: Amander Clark

Research Project:

Matthew is investigating the maturation of germ cell progenitors.

Feiyang Ma

Mentor: Matteo Pellegrini

Research Project:

Feiyang is focusing on developing single cell RNA sequencing methods and subsequent data analysis.

Matilde Miranda

Mentor: Bill Lowry
Research project:

Matilde is investigating the role of metabolism in hair follicle stem cell homeostasis and its role during epidermal aging.

 

Matthew Nitzahn

Mentor: Gerald Lipshutz

Research project:

Matt is using iPSCs and viruses to investigate gene therapy strategies for congenital liver metabolism disorders.

Jessica Ong

Mentor: Karen Reue
Research project:

Jessica is examining the physiological roles of a protein called Diet1 in the mouse model organism. A lack of Diet1 has previously been shown to make mice less susceptible to hypercholesterolemia when put on an atherogenic diet due to an enhanced bile acid secretion phenotype.

Publications:

Hmga2 is dispensable for cutaneous squamous cell carcinoma. White A, Flores A, Ong J, Lowry WE. Exp Dermatol. 2016 May;25(5):409-12. doi: 10.1111/exd.12978

Anna Sahakyan

Mentor: Kathrin Plath
Research project:

Anna studies the process of X chromosome inactivation in human cells, particularly how the long non-coding RNA XIST induces chromosome-wide silencing upon differentiation of female pluripotent cells.

Publications:

Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation. Sahakyan A, Kim R, Chronis C, Sabri S, Bonora G, Theunissen TW, Kuoy E, Langerman J, Clark AT, Jaenisch R, Plath K. Cell Stem Cell. 2017 Jan 5;20(1):87-101. doi: 10.1016/j.stem.2016.10.006. Epub 2016 Dec 15

Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation. Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJ, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K. Cell Rep. 2017 Jan 3;18(1):54-67. doi: 10.1016/j.celrep.2016.11.054. Epub 2016 Dec 16.

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. Cell Stem Cell. 2016 Sep 3. pii: S1934-5909(16)30255-7. doi: 10.1016/j.stem.2016.08.008. [Epub ahead of print]

Transcriptome Encyclopedia of Early Human Development. Sahakyan A, Plath K. Cell. 2016 May 5;165(4):777-9. doi: 10.1016/j.cell.2016.04.042.

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory. Pastor WA, Chen D, Liu W, Kim R, Sahakyan A, Lukianchikov A, Plath K, Jacobsen SE, Clark AT. Cell Stem Cell. 2016 Mar 3;18(3):323-9. doi: 10.1016/j.stem.2016.01.019. Epub 2016 Feb 4.

A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2′-dC upon inhibition of ribonucleotide reductase. Minkovsky A, Sahakyan A, Bonora G, Damoiseaux R, Dimitrova E, Rubbi L, Pellegrini M, Radu CG, Plath K. Epigenetics Chromatin. 2015 Oct 13;8:42. doi: 10.1186/s13072-015-0034-4. eCollection 2015

The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. Minkovsky A, Sahakyan A, Rankin-Gee E, Bonora G, Patel S, Plath K. Epigenetics Chromatin. 2014 Jun 26;7:12. doi: 10.1186/1756-8935-7-12. eCollection 2014.

 

Eriko Shimada

Mentor: Michael Teitell
Research project:

Eriko is currently researching mitochondrial RNA import pathways and import signals.

Publications:

Mitochondria-targeted RNA import. Wang G, Shimada E, Nili M, Koehler CM, Teitell MA. Methods Mol Biol. 2015;1264:107-16. doi: 10.1007/978-1-4939-2257-4_11.

Correcting human mitochondrial mutations with targeted RNA import. Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4840-5. doi: 10.1073/pnas.1116792109. Epub 2012 Mar 12.

PNPASE and RNA trafficking into mitochondria. Wang G, Shimada E, Koehler CM, Teitell MA. Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):998-1007. doi: 10.1016/j.bbagrm.2011.10.001. Epub 2011 Oct 13. Review.

Cynthia Shu

Mentor: Rachelle Crosbie-Watson
Research project:

Cynthia is using genetic and pharmacological approaches to target Sarcospan in Duchenne Muscular Dystrophy.

Yang Tao

Mentor: Kelsey Martin
Research project:

Yang is interested in activity dependent transfer of RNAs via extracellular vesicles(EVs) and how EVs contribute to neuronal synaptic plasticity.

Tara TeSlaa

Mentor: Michael Teitell
Research project:

Tara is currently studying the role of metabolism in human embryonic stem cells.

Publications:

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells. TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA. Cell Metab. 2016 Jul 27. pii: S1550-4131(16)30313-8. doi: 10.1016/j.cmet.2016.07.002. [Epub ahead of print]

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D, Koehler CM, Graeber TG, Chiou PY, Teitell MA. Cell Metab. 2016 May 10;23(5):921-9. doi: 10.1016/j.cmet.2016.04.007.

Mitochondria in human pluripotent stem cell apoptosis. TeSlaa T, Setoguchi K, Teitell MA. Semin Cell Dev Biol. 2016 Apr;52:76-83. doi: 10.1016/j.semcdb.2016.01.027. Epub 2016 Jan 30. Review.

P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. Setoguchi K, TeSlaa T, Koehler CM, Teitell MA. J Mol Biol. 2016 Apr 10;428(7):1465-75. doi: 10.1016/j.jmb.2015.07.019. Epub 2015 Jul 31.

Pluripotent stem cell energy metabolism: an update. Teslaa T, Teitell MA. EMBO J. 2015 Jan 13;34(2):138-53. doi: 10.15252/embj.201490446. Epub 2014 Dec 4. Review.

Techniques to monitor glycolysis. TeSlaa T, Teitell MA. Methods Enzymol. 2014;542:91-114. doi: 10.1016/B978-0-12-416618-9.00005-4. Review

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. EMBO J. 2014 Jul 1;33(13):1454-73. doi: 10.15252/embj.201488598. Epub 2014 May 13.

Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells. Xu J, Teslaa T, Wu TH, Chiou PY, Teitell MA, Weiss S. Nano Lett. 2012 Nov 14;12(11):5669-72. doi: 10.1021/nl302821g. Epub 2012 Nov 5.

Pulsed laser triggered high speed microfluidic fluorescence activated cell sorter. Wu TH, Chen Y, Park SY, Hong J, Teslaa T, Zhong JF, Di Carlo D, Teitell MA, Chiou PY. Lab Chip. 2012 Apr 7;12(7):1378-83. doi: 10.1039/c2lc21084c. Epub 2012 Feb 24.

Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade. French CT, Toesca IJ, Wu TH, Teslaa T, Beaty SM, Wong W, Liu M, Schröder I, Chiou PY, Teitell MA, Miller JF. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12095-100. doi: 10.1073/pnas.1107183108. Epub 2011 Jul 5.

Photothermal nanoblade for large cargo delivery into mammalian cells. Wu TH, Teslaa T, Kalim S, French CT, Moghadam S, Wall R, Miller JF, Witte ON, Teitell MA, Chiou PY. Anal Chem. 2011 Feb 15;83(4):1321-7. doi: 10.1021/ac102532w. Epub 2011 Jan 19.

Photothermal nanoblade for patterned cell membrane cutting. Wu TH, Teslaa T, Teitell MA, Chiou PY. Opt Express. 2010 Oct 25;18(22):23153-60. doi: 10.1364/OE.18.023153.

 

Aaron Van Loon

Mentor: Alvaro Sagasti
Research project:

Aaron is determining the structure and mechanism of epithelial microridge development in zebrafish.

Anastasia Vavilina

Mentor: Hanna Mikkola

Research Project:

Anastasia studies transcription factors governing hematopoietic stem cell proliferation, self-renewal, and differentiation.

Courtney Young

Mentor: Melissa Spencer
Research project:

Courtney’s research focus is to develop a CRISPR/Cas9-mediated gene editing therapy for Duchenne muscular dystrophy.

Publications:

Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy. Young CS, Mokhonova E, Quinonez M, Pyle AD, Spencer MJ. J Neuromuscul Dis. 2017;4(2):139-145. doi: 10.3233/JND-170218.

Exon Skipping Therapy. Young CS, Pyle AD. Cell. 2016 Nov 17;167(5):1144. doi: 10.1016/j.cell.2016.10.050.

CRISPR/Cas9-mediated correction of the sickle mutation in human CD34+ cells. Hoban MD, Lumaquin D, Kuo CY, Romero Z, Long J, Ho M, Young CS, Mojadidi M, Fitz-Gibbon S, Cooper AR, Lill GR, Urbinati F, Campo-Fernandez B, Bjurstrom CF, Pellegrini M, Hollis RP, Kohn DB. Mol Ther. 2016 Jul 13. doi: 10.1038/mt.2016.148. [Epub ahead of print]

A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. Cell Stem Cell. 2016 Apr 7;18(4):533-40. doi: 10.1016/j.stem.2016.01.021. Epub 2016 Feb 11.

Yurun Zhang

Mentor: John Chute
Research project:

Yurun studies the effects of PTPRS inhibition in hematopoietic stem cells.

Publications:

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP. Cell Rep. 2016 Nov 1;17(6):1584-1594. doi: 10.1016/j.celrep.2016.10.025.

A Small Molecule Inhibitor of Protein Tyrosine Phosphatase-Sigma (PTPσ) Promotes Hematopoietic Stem Cell (HSC) RegenerationZhang, Y., Quarmyne, M., Himburg, H. A., Yan, X., McBride, W., Jung, M., & Chute, J. P. Blood 128, no. 22 (2016)822.