Quen Cheng

Quen Cheng

Home Area: Immunity, Microbes, and Molecular Pathogenesis
Mentor: Alexander Hoffmann
Research project:

Quen Cheng is an infectious diseases physician pursuing a Ph.D. as part of the UCLA STAR program, and his research is in the molecular regulation of innate immune responses. These molecular pathways must be finely tuned to appropriately respond to a wide range of danger signals triggered by infection, and their regulation is highly dependent on cellular context. Using a systems biology approach, Quen aims to characterize the diversity of macrophage responses when primed with different cytokines, and to understand the differential effects of type I interferon on infected vs bystander cells.

Publications:

Sequential conditioning-stimulation reveals distinct gene- and stimulus-spcific effects of Type I and II IFN on human macrophage functionsCheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin R, Hoffmann A. Sequential conditioning-stimulation reveals distinct gene- and stimulus-spcific effects of Type I and II IFN on human macrophage functions. Scientific Reports. 2019; 9:5288. doi: 10.1038/s41598-019-40503-y

An NFkB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFkB via Distinct Mechanisms – Mercado EL, Mitchell S, Ho J, Fortmann K, Adelaja A, Cheng QJ, Ghosh G, Hoffmann A. An NFkB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFkB via Distinct Mechanisms. Frontiers in Immunology. 2019; 10:1425. doi: 10.3389/fimmu.2019.01425