Grace M Aldrovandi
/in /by Grant Alkin
Grace M Aldrovandi
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Affiliations
Research Interests
Effects of Human Milk Oligosaccharides and Gut Microbiome on Growth and Morbidity in HIV-Exposed Uninfected Infants
NIH R01HD096999Apr 24, 2019 – Mar 31, 2024
Role: Co-Principal Investigator
NIH R01HD096999Apr 24, 2019 – Mar 31, 2024
Role: Co-Principal Investigator
Maturation, Infectibility, and Trauma(MIT) Contributes to HIV Susceptibility in Adolescents
NIH R01AI128796Feb 24, 2017 – Jan 31, 2021
Role: Principal Investigator
NIH R01AI128796Feb 24, 2017 – Jan 31, 2021
Role: Principal Investigator
AIDS Clinical Trial Group Laboratory Center
NIH UM1AI106701Jan 1, 2014 – Nov 30, 2027
Role: Principal Investigator
NIH UM1AI106701Jan 1, 2014 – Nov 30, 2027
Role: Principal Investigator
International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network
NIH UM1AI106716Jan 1, 2014 – Nov 30, 2027
Role: Principal Investigator
NIH UM1AI106716Jan 1, 2014 – Nov 30, 2027
Role: Principal Investigator
Oral Transmission of HIV through Breastfeeding
NIH R01DE021238Sep 1, 2010 – May 31, 2015
Role: Co-Principal Investigator
NIH R01DE021238Sep 1, 2010 – May 31, 2015
Role: Co-Principal Investigator
Publications
A selected list of publications:
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination. Mucosal Immunol. 2022 05; 15(5):1040-1047. Pannaraj PS, da Costa-Martins AG, Cerini C, Li F, Wong SS, Singh Y, Urbanski AH, Gonzalez-Dias P, Yang J, Webby RJ, Nakaya HI, Aldrovandi GM. PMID: 35739193; PMCID: PMC9225800.
Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods. PLoS One. 2022; 17(6):e0270150. Smith ER, Oakley E, He S, Zavala R, Ferguson K, Miller L, Grandner GW, Abejirinde IO, Afshar Y, Ahmadzia H, Aldrovandi G, Akelo V, Tippett Barr BA, Bevilacqua E, Brandt JS, Broutet N, Fernández Buhigas I, Carrillo J, Clifton R, Conry J, Cosmi E, Delgado-López C, Divakar H, Driscoll AJ, Favre G, Flaherman V, Gale C, Gil MM, Godwin C, Gottlieb S, Hernandez Bellolio O, Kara E, Khagayi S, Kim CR, Knight M, Kotloff K, Lanzone A, Le Doare K, Lees C, Litman E, Lokken EM, Laurita Longo V, Magee LA, Martinez-Portilla RJ, McClure E, Metz TD, Money D, Mullins E, Nachega JB, Panchaud A, Playle R, Poon LC, Raiten D, Regan L, Rukundo G, Sanin-Blair J, Temmerman M, Thorson A, Thwin S, Tolosa JE, Townson J, Valencia-Prado M, Visentin S, von Dadelszen P, Adams Waldorf K, Whitehead C, Yang H, Thorlund K, Tielsch JM. PMID: 35709239; PMCID: PMC9202913.
Zoster Meningitis in an Immunocompetent Child after COVID-19 Vaccination, California, USA. Emerg Infect Dis. 2022 07; 28(7):1523-1524. Daouk SK, Kamau E, Adachi K, Aldrovandi GM. PMID: 35680126; PMCID: PMC9239884.
Longitudinal Assessment of Coronavirus Disease 2019 Vaccine Acceptance and Uptake Among Frontline Medical Workers in Los Angeles, California. Clin Infect Dis. 2022 04 09; 74(7):1166-1173. Halbrook M, Gadoth A, Martin-Blais R, Gray AN, Kashani S, Kazan C, Kane B, Tobin NH, Ferbas KG, Aldrovandi GM, Rimoin AW. PMID: 34292319.
Dominant CD8+ T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From Vaccination. Front Immunol. 2022; 13:835830. Taus E, Hofmann C, Ibarrondo FJ, Hausner MA, Fulcher JA, Krogstad P, Ferbas KG, Tobin NH, Rimoin AW, Aldrovandi GM, Yang OO. PMID: 35273611; PMCID: PMC8902813.
A Summary of the Sixth International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment. AIDS Res Hum Retroviruses. 2022 03; 38(3):173-180. Sherrill-Mix S, Yang M, Aldrovandi GM, Brenchley JM, Bushman FD, Collman RG, Dandekar S, Klatt NR, Lagenaur LA, Landay AL, Paredes R, Tachedjian G, Turpin JA, Serrano-Villar S, Lozupone CA, Ghosh M. PMID: 34969255; PMCID: PMC9009592.
No infectious SARS-CoV-2 in breast milk from a cohort of 110 lactating women. Pediatr Res. 2022 Oct; 92(4):1140-1145. Krogstad P, Contreras D, Ng H, Tobin N, Chambers CD, Bertrand K, Bode L, Aldrovandi GM. PMID: 35042956; PMCID: PMC9586866.
A pilot study of microbial signatures of liver disease in those with HIV mono-infection in Rio de Janeiro, Brazil. AIDS. 2022 01 01; 36(1):49-58. Yanavich C, Perazzo H, Li F, Tobin N, Lee D, Zabih S, Morata M, Almeida C, Veloso VG, Grinsztejn B, Aldrovandi GM. PMID: 34873092; PMCID: PMC8667204.
Humoral responses to SARS-CoV-2 mRNA vaccines: Role of past infection. PLoS One. 2021; 16(11):e0259703. Gray AN, Martin-Blais R, Tobin NH, Wang Y, Brooker SL, Li F, Gadoth A, Elliott J, Faure-Kumar E, Halbrook M, Hofmann C, Kashani S, Kazan C, Yang OO, Fulcher JA, Grovit-Ferbas K, Rimoin AW, Aldrovandi GM. PMID: 34748607; PMCID: PMC8575273.
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell Rep Med. 2021 11 16; 2(11):100453. Foo SS, Cambou MC, Mok T, Fajardo VM, Jung KL, Fuller T, Chen W, Kerin T, Mei J, Bhattacharya D, Choi Y, Wu X, Xia T, Shin WJ, Cranston J, Aldrovandi G, Tobin N, Contreras D, Ibarrondo FJ, Yang O, Yang S, Garner O, Cortado R, Bryson Y, Janzen C, Ghosh S, Devaskar S, Asilnejad B, Moreira ME, Vasconcelos Z, Soni PR, Gibson LC, Brasil P, Comhair SAA, Arumugaswami V, Erzurum SC, Rao R, Jung JU, Nielsen-Saines K. PMID: 34723226; PMCID: PMC8549189.
Metabolomic Predictors of Non-alcoholic Steatohepatitis and Advanced Fibrosis in Children. Front Microbiol. 2021; 12:713234. Kordy K, Li F, Lee DJ, Kinchen JM, Jew MH, La Rocque ME, Zabih S, Saavedra M, Woodward C, Cunningham NJ, Tobin NH, Aldrovandi GM. PMID: 34475864; PMCID: PMC8406633.
Microbiome is not linked to clinical disease severity of familial Mediterranean fever in an international cohort of children. Clin Exp Rheumatol. 2021 Sep-Oct; 39 Suppl 132(5):102-108. Ozen S, Lutz HL, Rivera VM, Reiff A, Batu ED, Anderson E, Salas Garcia M, Aldrovandi G, Akbaba TH, Pazarbasi I, Bilginer Y, Balat A, Balci-Peynircioglu B, Gilbert JA, Dedeoglu F, Hausmann JS. PMID: 34251310.
Comparison of dried blood spot and plasma sampling for untargeted metabolomics. Metabolomics. 2021 06 23; 17(7):62. Tobin NH, Murphy A, Li F, Brummel SS, Taha TE, Saidi F, Owor M, Violari A, Moodley D, Chi B, Goodman KD, Koos B, Aldrovandi GM. PMID: 34164733; PMCID: PMC8340475.
Primary, Recall, and Decay Kinetics of SARS-CoV-2 Vaccine Antibody Responses. ACS Nano. 2021 07 27; 15(7):11180-11191. Ibarrondo FJ, Hofmann C, Fulcher JA, Goodman-Meza D, Mu W, Hausner MA, Ali A, Balamurugan A, Taus E, Elliott J, Krogstad P, Tobin NH, Ferbas KG, Kitchen SG, Aldrovandi GM, Rimoin AW, Yang OO. PMID: 34159781.
An HIV Diagnostic Testing Algorithm Using the cobas HIV-1/HIV-2 Qualitative Assay for HIV Type Differentiation and Confirmation. J Clin Microbiol. 2021 06 18; 59(7):e0303020. Duncan D, Duncan J, Kramer B, Nilsson AY, Haile B, Butcher A, Chugh S, Baum P, Aldrovandi GM, Young S, Avery AK, Tashima K, Valsamakis A, Yao JD, Chang M, Coombs RW. PMID: 33853869; PMCID: PMC8218759.
Complicated Monochorionic-Diamniotic Twins in a Pregnant Woman with COVID-19 in the Second Trimester. Am J Perinatol. 2021 06; 38(7):747-752. Mok T, Contreras D, Chmait RH, Goldstein J, Pluym ID, Tabsh K, Aldrovandi G, Afshar Y. PMID: 33853148.
No Evidence of Infectious SARS-CoV-2 in Human Milk: Analysis of a Cohort of 110 Lactating Women. medRxiv. 2021 Apr 07. Krogstad P, Contreras D, Ng H, Tobin N, Chambers CD, Bertrand K, Bode L, Aldrovandi G. PMID: 33851178; PMCID: PMC8043475.
Cross-sectional Assessment of COVID-19 Vaccine Acceptance Among Health Care Workers in Los Angeles. Ann Intern Med. 2021 06; 174(6):882-885. Gadoth A, Halbrook M, Martin-Blais R, Gray A, Tobin NH, Ferbas KG, Aldrovandi GM, Rimoin AW. PMID: 33556267; PMCID: PMC7926184.
Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding. J Clin Pediatr Neonatol. 2021; 1(1):9-20. Yin L, Chang KF, Nakamura KJ, Kuhn L, Aldrovandi GM, Goodenow MM. PMID: 34553192; PMCID: PMC8454918.
Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People. Obstet Gynecol. 2020 12; 136(6):1117-1125. Afshar Y, Gaw SL, Flaherman VJ, Chambers BD, Krakow D, Berghella V, Shamshirsaz AA, Boatin AA, Aldrovandi G, Greiner A, Riley L, Boscardin WJ, Jamieson DJ, Jacoby VL, Pregnancy CoRonavIrus Outcomes RegIsTrY (PRIORITY) Study. PMID: 33027186; PMCID: PMC7673633.
Immune Markers and Their Association with Bone Density in Children, Adolescents, and Young Adults with Perinatally Acquired HIV. AIDS Res Hum Retroviruses. 2021 02; 37(2):122-129. Jacobson D, Liu JZ, Lindsey JC, Shiau S, Coull B, Aldrovandi G. PMID: 33066711; PMCID: PMC7876354.
Evaluation for SARS-CoV-2 in Breast Milk From 18 Infected Women. JAMA. 2020 10 06; 324(13):1347-1348. Chambers C, Krogstad P, Bertrand K, Contreras D, Tobin NH, Bode L, Aldrovandi G. PMID: 32822495; PMCID: PMC7439212.
A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop. AIDS Res Hum Retroviruses. 2020 11; 36(11):886-895. Sherrill-Mix S, Connors K, Aldrovandi GM, Brenchley JM, Boucher C, Bushman FD, Collman RG, Dandekar S, Klatt NR, Lagenaur LA, Paredes R, Tachedjian G, Turpin JA, Landay AL, Ghosh M. PMID: 32777940; PMCID: PMC7869876.
Rapid Decay of Anti-SARS-CoV-2 Antibodies in Persons with Mild Covid-19. N Engl J Med. 2020 09 10; 383(11):1085-1087. Ibarrondo FJ, Fulcher JA, Goodman-Meza D, Elliott J, Hofmann C, Hausner MA, Ferbas KG, Tobin NH, Aldrovandi GM, Yang OO. PMID: 32706954; PMCID: PMC7397184.
Impact of Clinical Factors on the Intestinal Microbiome in Infants With Gastroschisis. JPEN J Parenter Enteral Nutr. 2021 05; 45(4):818-825. Wu AJ, Lee DJ, Li F, Tobin NH, Aldrovandi GM, Shew SB, Calkins KL. PMID: 32441784; PMCID: PMC9197548.
Evaluation of SARS-CoV-2 in Breastmilk from 18 Infected Women. medRxiv. 2020 Jun 16. Chambers CD, Krogstad P, Bertrand K, Contreras D, Tobin NH, Bode L, Aldrovandi GM. PMID: 32587991; PMCID: PMC7310649.
The neovaginal microbiome of transgender women post-gender reassignment surgery. Microbiome. 2020 05 05; 8(1):61. Birse KD, Kratzer K, Zuend CF, Mutch S, Noël-Romas L, Lamont A, Abou M, Jalil E, Veloso V, Grinsztejn B, Friedman RK, Broliden K, Bradley F, Poliquin V, Li F, Yanavich C, Burgener A, Aldrovandi G. PMID: 32370783; PMCID: PMC7201977.
Pregnancy associates with alterations to the host and microbial proteome in vaginal mucosa. Am J Reprod Immunol. 2020 06; 83(6):e13235. Farr Zuend C, Tobin NH, Vera T, Kotyrba L, Noël-Romas L, Birse K, Mutch S, Li F, Lee D, McCorrister S, Westmacott G, Aldrovandi GM, Burgener AD. PMID: 32196803; PMCID: PMC7317380.
Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient. Antimicrob Agents Chemother. 2020 03 24; 64(4). Contreras DA, Fitzwater SP, Nanayakkara DD, Schaenman J, Aldrovandi GM, Garner OB, Yang S. PMID: 31527031; PMCID: PMC7179284.
Contributions to human breast milk microbiome and enteromammary transfer of Bifidobacterium breve. PLoS One. 2020; 15(1):e0219633. Kordy K, Gaufin T, Mwangi M, Li F, Cerini C, Lee DJ, Adisetiyo H, Woodward C, Pannaraj PS, Tobin NH, Aldrovandi GM. PMID: 31990909; PMCID: PMC6986747.
Early antiretroviral treatment of infants to attain HIV remission. EClinicalMedicine. 2020 Jan; 18:100241. Kuhn L, Strehlau R, Shiau S, Patel F, Shen Y, Technau KG, Burke M, Sherman G, Coovadia A, Aldrovandi GM, Hazra R, Tsai WY, Tiemessen CT, Abrams EJ, LEOPARD Study Team. PMID: 31993578; PMCID: PMC6978195.
Emerging evidence from a systematic review of safety of pre-exposure prophylaxis for pregnant and postpartum women: where are we now and where are we heading? J Int AIDS Soc. 2020 01; 23(1):e25426. Joseph Davey DL, Pintye J, Baeten JM, Aldrovandi G, Baggaley R, Bekker LG, Celum C, Chi BH, Coates TJ, Haberer JE, Heffron R, Kinuthia J, Matthews LT, McIntyre J, Moodley D, Mofenson LM, Mugo N, Myer L, Mujugira A, Shoptaw S, Stranix-Chibanda L, John-Stewart G, PrEP in Pregnancy Working Group. PMID: 31912985; PMCID: PMC6948023.
Combined effects of HIV and obesity on the gastrointestinal microbiome of young men who have sex with men. HIV Med. 2020 07; 21(6):365-377. Cook RR, Fulcher JA, Tobin NH, Li F, Lee D, Woodward C, Javanbakht M, Brookmeyer R, Shoptaw S, Bolan R, Aldrovandi GM, Gorbach PM. PMID: 31883184; PMCID: PMC7299823.
Early exposure to antibiotics in the neonatal intensive care unit alters the taxonomic and functional infant gut microbiome. J Matern Fetal Neonatal Med. 2021 Oct; 34(20):3335-3343. Bender JM, Li F, Purswani H, Capretz T, Cerini C, Zabih S, Hung L, Francis N, Chin S, Pannaraj PS, Aldrovandi G. PMID: 31744351; PMCID: PMC7234909.
Rectal Microbiome Alterations Associated With Oral Human Immunodeficiency Virus Pre-Exposure Prophylaxis. Open Forum Infect Dis. 2019 Nov; 6(11):ofz463. Fulcher JA, Li F, Cook RR, Zabih S, Louie A, Okochi H, Tobin NH, Gandhi M, Shoptaw S, Gorbach PM, Aldrovandi GM. PMID: 32258202; PMCID: PMC7105055.
Alterations to the Gastrointestinal Microbiome Associated with Methamphetamine Use among Young Men who have Sex with Men. Sci Rep. 2019 10 16; 9(1):14840. Cook RR, Fulcher JA, Tobin NH, Li F, Lee DJ, Woodward C, Javanbakht M, Brookmeyer R, Shoptaw S, Bolan R, Aldrovandi GM, Gorbach PM. PMID: 31619731; PMCID: PMC6795845.
Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. AIDS Res Hum Retroviruses. 2019 08; 35(8):746-754. Kim-Chang JJ, Wilson L, Chan C, Fischer B, Venturi G, Goodenow MM, Aldrovandi G, Weber TJ, Sleasman JW, Adolescent Medicine Trials Network for HIV/AIDS Interventions. PMID: 31115244; PMCID: PMC6688113.
Effects of HIV viremia on the gastrointestinal microbiome of young MSM. AIDS. 2019 04 01; 33(5):793-804. Cook RR, Fulcher JA, Tobin NH, Li F, Lee D, Javanbakht M, Brookmeyer R, Shoptaw S, Bolan R, Aldrovandi GM, Gorbach PM. PMID: 30649052; PMCID: PMC6422698.
HIV and SIV in Body Fluids: From Breast Milk to the Genitourinary Tract. Curr Immunol Rev. 2019; 15(1):139-152. Kordy K, Tobin NH, Aldrovandi GM. PMID: 33312088; PMCID: PMC7730163.
Metabolic effects of initiating lopinavir/ritonavir-based regimens among young children. AIDS. 2018 10 23; 32(16):2327-2336. Patel K, Lindsey J, Angelidou K, Aldrovandi G, Palumbo P, IMPAACT P1060 Study Team. PMID: 30102656; PMCID: PMC6170714.
Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nat Commun. 2018 10 09; 9(1):4169. Ho NT, Li F, Lee-Sarwar KA, Tun HM, Brown BP, Pannaraj PS, Bender JM, Azad MB, Thompson AL, Weiss ST, Azcarate-Peril MA, Litonjua AA, Kozyrskyj AL, Jaspan HB, Aldrovandi GM, Kuhn L. PMID: 30301893; PMCID: PMC6177445.
Effects of Substance Use and Sex Practices on the Intestinal Microbiome During HIV-1 Infection. J Infect Dis. 2018 10 05; 218(10):1560-1570. Fulcher JA, Hussain SK, Cook R, Li F, Tobin NH, Ragsdale A, Shoptaw S, Gorbach PM, Aldrovandi GM. PMID: 29982500; PMCID: PMC6692862.
Quantification of variation and the impact of biomass in targeted 16S rRNA gene sequencing studies. Microbiome. 2018 09 10; 6(1):155. Bender JM, Li F, Adisetiyo H, Lee D, Zabih S, Hung L, Wilkinson TA, Pannaraj PS, She RC, Bard JD, Tobin NH, Aldrovandi GM. PMID: 30201048; PMCID: PMC6131952.
Combination Antibiotics Improves Disease Activity and Alters Microbial Communities in Children With Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2018 09; 67(3):e60-e63. Kordy K, Romeo AC, Lee DJ, Li F, Zabih S, Saavedra M, Cunningham NJ, Tobin N, Aldrovandi GM. PMID: 29762192; PMCID: PMC6103819.
Shared and Distinct Features of Human Milk and Infant Stool Viromes. Front Microbiol. 2018; 9:1162. Pannaraj PS, Ly M, Cerini C, Saavedra M, Aldrovandi GM, Saboory AA, Johnson KM, Pride DT. PMID: 29910789; PMCID: PMC5992295.
A Method for Targeted 16S Sequencing of Human Milk Samples. J Vis Exp. 2018 03 23; (133). Tobin NH, Woodward C, Zabih S, Lee DJ, Li F, Aldrovandi GM. PMID: 29630048; PMCID: PMC5933250.
The importance of the microbiome in pediatrics and pediatric infectious diseases. Curr Opin Pediatr. 2018 02; 30(1):117-124. Gaufin T, Tobin NH, Aldrovandi GM. PMID: 29206649; PMCID: PMC6588283.
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi’s Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. mBio. 2018 01 16; 9(1). Lee HR, Li F, Choi UY, Yu HR, Aldrovandi GM, Feng P, Gao SJ, Hong YK, Jung JU. PMID: 29339432; PMCID: PMC5770555.
The Association of Fat and Lean Tissue With Whole Body and Spine Bone Mineral Density Is Modified by HIV Status and Sex in Children and Youth. Pediatr Infect Dis J. 2018 Jan; 37(1):71-77. Jacobson DL, Lindsey JC, Coull BA, Mulligan K, Bhagwat P, Aldrovandi GM, Pediatric AIDS Clinical Trials Group P1045 Team. PMID: 28817419; PMCID: PMC5725259.
Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing. J Pediatric Infect Dis Soc. 2017 Nov 24; 6(4):393-398. Mongkolrattanothai K, Naccache SN, Bender JM, Samayoa E, Pham E, Yu G, Dien Bard J, Miller S, Aldrovandi G, Chiu CY. PMID: 28062553; PMCID: PMC6251619.
Duodenoscope-Related Outbreak of a Carbapenem-Resistant Klebsiella pneumoniae Identified Using Advanced Molecular Diagnostics. Clin Infect Dis. 2017 10 01; 65(7):1159-1166. Humphries RM, Yang S, Kim S, Muthusamy VR, Russell D, Trout AM, Zaroda T, Cheng QJ, Aldrovandi G, Uslan DZ, Hemarajata P, Rubin ZA. PMID: 29579235.
HIV birth testing and linkage to care for HIV-infected infants. AIDS. 2017 08 24; 31(13):1797-1807. Jean-Philippe P, Spiegel H, Gnanashanmugam D, Fitzgibbon J, D’Souza P, Crawford KW, Jayashankar L, Bacon MC, Essajee SM, Aldrovandi GM, Cotton M, Abrams EJ. PMID: 28590330.
Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome. JAMA Pediatr. 2017 07 01; 171(7):647-654. Pannaraj PS, Li F, Cerini C, Bender JM, Yang S, Rollie A, Adisetiyo H, Zabih S, Lincez PJ, Bittinger K, Bailey A, Bushman FD, Sleasman JW, Aldrovandi GM. PMID: 28492938; PMCID: PMC5710346.
Evolution and Transmission of Carbapenem-Resistant Klebsiella pneumoniae Expressing the blaOXA-232 Gene During an Institutional Outbreak Associated With Endoscopic Retrograde Cholangiopancreatography. Clin Infect Dis. 2017 Apr 01; 64(7):894-901. Yang S, Hemarajata P, Hindler J, Li F, Adisetiyo H, Aldrovandi G, Sebra R, Kasarskis A, MacCannell D, Didelot X, Russell D, Rubin Z, Humphries R. PMID: 28362935.
Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures. Retrovirology. 2017 01 26; 14(1):6. Nakamura KJ, Heath L, Sobrera ER, Wilkinson TA, Semrau K, Kankasa C, Tobin NH, Webb NE, Lee B, Thea DM, Kuhn L, Mullins JI, Aldrovandi GM. PMID: 28122636; PMCID: PMC5267468.
Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021. J Acquir Immune Defic Syndr. 2016 08 01; 72(4):372-5. Ruan A, Tobin NH, Mulligan K, Rollie A, Li F, Sleasman J, Aldrovandi GM. PMID: 26885808; PMCID: PMC4925249.
Maternal HIV infection influences the microbiome of HIV-uninfected infants. Sci Transl Med. 2016 07 27; 8(349):349ra100. Bender JM, Li F, Martelly S, Byrt E, Rouzier V, Leo M, Tobin N, Pannaraj PS, Adisetiyo H, Rollie A, Santiskulvong C, Wang S, Autran C, Bode L, Fitzgerald D, Kuhn L, Aldrovandi GM. PMID: 27464748; PMCID: PMC5301310.
Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 05 19; 62(4):507-19. Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O’Connell D, Zhang T, Pirooz SD, Jeon YH, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. PMID: 27203177; PMCID: PMC4875571.
Influenza Vaccine is Protective Against Laboratory-confirmed Influenza in Obese Children. Pediatr Infect Dis J. 2016 Apr; 35(4):440-5. Smit MA, Wang HL, Kim E, Barragan N, Aldrovandi GM, El Amin AN, Mascola L, Pannaraj PS. PMID: 26658380; PMCID: PMC4788535.
Investigation of a suspected nosocomial transmission of blaKPC3-mediated carbapenem-resistant Klebsiella pneumoniae by whole genome sequencing. Diagn Microbiol Infect Dis. 2016 Apr; 84(4):337-42. Yang S, Hemarajata P, Hindler J, Ward K, Adisetiyo H, Li F, Aldrovandi GM, Green NM, Russell D, Rubin Z, Humphries RM. PMID: 26867964.
Acute Flaccid Myelitis of Unknown Etiology in California, 2012-2015. JAMA. 2015 Dec 22-29; 314(24):2663-71. Van Haren K, Ayscue P, Waubant E, Clayton A, Sheriff H, Yagi S, Glenn-Finer R, Padilla T, Strober JB, Aldrovandi G, Wadford DA, Chiu CY, Xia D, Harriman K, Watt JP, Glaser CA. PMID: 26720027.
Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity. J Virol. 2015 Nov; 89(21):10868-78. Wahl A, Baker C, Spagnuolo RA, Stamper LW, Fouda GG, Permar SR, Hinde K, Kuhn L, Bode L, Aldrovandi GM, Garcia JV. PMID: 26292320; PMCID: PMC4621099.
A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops. PLoS One. 2015; 10(6):e0128116. Lombardi F, Nakamura KJ, Chen T, Sobrera ER, Tobin NH, Aldrovandi GM. PMID: 26083631; PMCID: PMC4471078.
A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015 Jun; 15(6):671-82. Greninger AL, Naccache SN, Messacar K, Clayton A, Yu G, Somasekar S, Federman S, Stryke D, Anderson C, Yagi S, Messenger S, Wadford D, Xia D, Watt JP, Van Haren K, Dominguez SR, Glaser C, Aldrovandi G, Chiu CY. PMID: 25837569; PMCID: PMC6027625.
Abdominal obesity contributes to neurocognitive impairment in HIV-infected patients with increased inflammation and immune activation. J Acquir Immune Defic Syndr. 2015 Mar 01; 68(3):281-8. Sattler FR, He J, Letendre S, Wilson C, Sanders C, Heaton R, Ellis R, Franklin D, Aldrovandi G, Marra CM, Clifford D, Morgello S, Grant I, McCutchan JA, CHARTER Group. PMID: 25469522; PMCID: PMC4551458.
Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia. J Nutr. 2015 Jan; 145(1):66-72. Kuhn L, Kim HY, Hsiao L, Nissan C, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM, Bode L. PMID: 25527660; PMCID: PMC4264023.
Exploration of the Effect of Tobacco Smoking on Metabolic Measures in Young People Living with HIV. AIDS Res Treat. 2014; 2014:740545. Rubinstein ML, Harris DR, Rudy BJ, Kapogiannis BG, Aldrovandi GM, Mulligan K. PMID: 25114801; PMCID: PMC4119894.
View in: PubMed Mentions: 2
School-located influenza vaccination decreases laboratory-confirmed influenza and improves school attendance. Clin Infect Dis. 2014 Aug 01; 59(3):325-32. Pannaraj PS, Wang HL, Rivas H, Wiryawan H, Smit M, Green N, Aldrovandi GM, El Amin AN, Mascola L. PMID: 24829215; PMCID: PMC4155443.
Human parechovirus central nervous system infections in southern California children. Pediatr Infect Dis J. 2014 Apr; 33(4):e87-91. Felsenstein S, Yang S, Eubanks N, Sobrera E, Grimm JP, Aldrovandi G. PMID: 24104958.
HLA-G 14 bp deletion/insertion polymorphism and mother-to-child transmission of HIV. Tissue Antigens. 2014 Mar; 83(3):161-7. Segat L, Zupin L, Kim HY, Catamo E, Thea DM, Kankasa C, Aldrovandi GM, Kuhn L, Crovella S. PMID: 24571474; PMCID: PMC3950813.
Are infants unique in their ability to be “functionally cured” of HIV-1? Curr HIV/AIDS Rep. 2014 Mar; 11(1):1-10. Tobin NH, Aldrovandi GM. PMID: 24390641.
Human milk galectin-3 binding protein and breast-feeding-associated HIV transmission. Pediatr Infect Dis J. 2013 Dec; 32(12):e473-5. Chan CS, Kim HY, Autran C, Kim JH, Sinkala M, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM, Kuhn L, Bode L. PMID: 23899964; PMCID: PMC3907473.
Psychrobacter immobilis septicemia in a boy with X-linked chronic granulomatous disease and fulminant hepatic failure. J Clin Immunol. 2014 Jan; 34(1):39-41. Sriaroon P, Elizalde A, Perez EE, Leiding JW, Aldrovandi GM, Sleasman JW. PMID: 24217814.
Microbial translocation and metabolic and body composition measures in treated and untreated HIV infection. AIDS Res Hum Retroviruses. 2014 Mar; 30(3):272-7. Timmons T, Shen C, Aldrovandi G, Rollie A, Gupta SK, Stein JH, Dubé MP. PMID: 24033288; PMCID: PMC3938948.
Immunology of pediatric HIV infection. Immunol Rev. 2013 Jul; 254(1):143-69. Tobin NH, Aldrovandi GM. PMID: 23772619; PMCID: PMC3737605.
HIV-1 concentrations in human breast milk before and after weaning. Sci Transl Med. 2013 Apr 17; 5(181):181ra51. Kuhn L, Kim HY, Walter J, Thea DM, Sinkala M, Mwiya M, Kankasa C, Decker D, Aldrovandi GM. PMID: 23596203; PMCID: PMC4557798.
Template protocol for clinical trials investigating vaccines–focus on safety elements. Vaccine. 2013 Nov 12; 31(47):5602-20. Bonhoeffer J, Imoukhuede EB, Aldrovandi G, Bachtiar NS, Chan ES, Chang S, Chen RT, Fernandopulle R, Goldenthal KL, Heffelfinger JD, Hossain S, Jevaji I, Khamesipour A, Kochhar S, Makhene M, Malkin E, Nalin D, Prevots R, Ramasamy R, Sellers S, Vekemans J, Walker KB, Wilson P, Wong V, Zaman K, Heininger U, Brighton Collaboration Clinical Trial Protocol Working Group. PMID: 23499603; PMCID: PMC4586124.
Dynamics of breast milk HIV-1 RNA with unilateral mastitis or abscess. J Acquir Immune Defic Syndr. 2013 Mar 01; 62(3):348-55. Semrau K, Kuhn L, Brooks DR, Cabral H, Sinkala M, Kankasa C, Thea DM, Aldrovandi GM. PMID: 23202812; PMCID: PMC3647002.
Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies. AIDS. 2013 Jan 28; 27(3):337-46. Nakamura KJ, Cerini C, Sobrera ER, Heath L, Sinkala M, Kankasa C, Thea DM, Mullins JI, Kuhn L, Aldrovandi GM. PMID: 23296195; PMCID: PMC3863550.
Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women. BMC Pediatr. 2012 Aug 31; 12:138. Kim HY, Kasonde P, Mwiya M, Thea DM, Kankasa C, Sinkala M, Aldrovandi G, Kuhn L. PMID: 22937874; PMCID: PMC3480840.
Relationship between microbial translocation and endothelial function in HIV infected patients. PLoS One. 2012; 7(8):e42624. Blodget E, Shen C, Aldrovandi G, Rollie A, Gupta SK, Stein JH, Dubé MP. PMID: 22952600; PMCID: PMC3431387.
Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding. Am J Clin Nutr. 2012 Oct; 96(4):831-9. Bode L, Kuhn L, Kim HY, Hsiao L, Nissan C, Sinkala M, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM. PMID: 22894939; PMCID: PMC3441110.
Milk matters: soluble Toll-like receptor 2 (sTLR2) in breast milk significantly inhibits HIV-1 infection and inflammation. PLoS One. 2012; 7(7):e40138. Henrick BM, Nag K, Yao XD, Drannik AG, Aldrovandi GM, Rosenthal KL. PMID: 22792230; PMCID: PMC3391222.
Brown adipose tissue and its relationship to bone structure in pediatric patients. J Clin Endocrinol Metab. 2012 Aug; 97(8):2693-8. Ponrartana S, Aggabao PC, Hu HH, Aldrovandi GM, Wren TA, Gilsanz V. PMID: 22593587; PMCID: PMC3410267.
Low bone mass in behaviorally HIV-infected young men on antiretroviral therapy: Adolescent Trials Network Study 021B. Clin Infect Dis. 2012 Aug; 55(3):461-8. Mulligan K, Harris DR, Emmanuel P, Fielding RA, Worrell C, Kapogiannis BG, Monte D, Sleasman J, Wilson CM, Aldrovandi GM, ATN 021 Protocol team. PMID: 22573848; PMCID: PMC3491777.
Using cluster heat maps to investigate relationships between body composition and laboratory measurements in HIV-infected and HIV-uninfected children and young adults. J Acquir Immune Defic Syndr. 2012 Mar 01; 59(3):325-8. Lindsey JC, Jacobson DL, Li H, Houseman EA, Aldrovandi GM, Mulligan K. PMID: 22083069; PMCID: PMC3288740.
Virologic determinants of breast milk transmission of HIV-1. Adv Exp Med Biol. 2012; 743:69-80. Fiscus SA, Aldrovandi GM. PMID: 22454342.
Pendulum swings in HIV-1 and infant feeding policies: now halfway back. Adv Exp Med Biol. 2012; 743:273-87. Kuhn L, Aldrovandi G. PMID: 22454357.
Editorial: developmental regulation of P-glycoprotein and HIV therapy: spare the thymus but spoil the child? J Leukoc Biol. 2011 Oct; 90(4):639-41. Krogstad P, Aldrovandi G. PMID: 21965311.
Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional study. BMC Infect Dis. 2011 Sep 30; 11:263. Walter J, Fraga L, Orin MJ, Decker WD, Gipps T, Stek A, Aldrovandi GM. PMID: 21961998; PMCID: PMC3190379.
Atazanavir and atazanavir/ritonavir pharmacokinetics in HIV-infected infants, children, and adolescents. AIDS. 2011 Jul 31; 25(12):1489-96. Kiser JJ, Rutstein RM, Samson P, Graham B, Aldrovandi G, Mofenson LM, Smith E, Schnittman S, Fenton T, Brundage RC, Fletcher CV. PMID: 21610486; PMCID: PMC3177533.
Exclusive breastfeeding, maternal HIV disease, and the risk of clinical breast pathology in HIV-infected, breastfeeding women. Am J Obstet Gynecol. 2011 Oct; 205(4):344.e1-8. Semrau K, Kuhn L, Brooks DR, Cabral H, Sinkala M, Kankasa C, Thea DM, Aldrovandi GM. PMID: 21784403; PMCID: PMC3217158.
Early weaning increases diarrhea morbidity and mortality among uninfected children born to HIV-infected mothers in Zambia. J Infect Dis. 2011 May 01; 203(9):1222-30. Fawzy A, Arpadi S, Kankasa C, Sinkala M, Mwiya M, Thea DM, Aldrovandi GM, Kuhn L. PMID: 21459815; PMCID: PMC3069726.
2050: Ending the odyssey of the great white plague. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni. Pharmacol Res. 2011 Sep; 64(3):176-9. Jassal MS, Aldrovandi GM. PMID: 21540112.
Multiple independent lineages of HIV-1 persist in breast milk and plasma. AIDS. 2011 Jan 14; 25(2):143-52. Gray RR, Salemi M, Lowe A, Nakamura KJ, Decker WD, Sinkala M, Kankasa C, Mulligan CJ, Thea DM, Kuhn L, Aldrovandi G, Goodenow MM. PMID: 21173592; PMCID: PMC3032216.
Survival and health benefits of breastfeeding versus artificial feeding in infants of HIV-infected women: developing versus developed world. Clin Perinatol. 2010 Dec; 37(4):843-62, x. Kuhn L, Aldrovandi G. PMID: 21078454; PMCID: PMC3008406.
What infants and breasts can teach us about natural protection from HIV infection. J Infect Dis. 2010 Nov 01; 202 Suppl 3:S366-70. Aldrovandi GM, Kuhn L. PMID: 20887226; PMCID: PMC2951298.
Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin Infect Dis. 2010 Oct 15; 51(8):937-46. McComsey GA, Tebas P, Shane E, Yin MT, Overton ET, Huang JS, Aldrovandi GM, Cardoso SW, Santana JL, Brown TT. PMID: 20839968; PMCID: PMC3105903.
Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to- child HIV transmission. AIDS. 2010 Jun 01; 24(9):1374-7. Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Mwiya M, Thea DM. PMID: 20568677; PMCID: PMC2946203.
Lactation-associated postpartum weight changes among HIV-infected women in Zambia. Int J Epidemiol. 2010 Oct; 39(5):1299-310. Murnane PM, Arpadi SM, Sinkala M, Kankasa C, Mwiya M, Kasonde P, Thea DM, Aldrovandi GM, Kuhn L. PMID: 20484334; PMCID: PMC2972438.
Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission. PLoS One. 2010 Apr 20; 5(4):e10213. Heath L, Conway S, Jones L, Semrau K, Nakamura K, Walter J, Decker WD, Hong J, Chen T, Heil M, Sinkala M, Kankasa C, Thea DM, Kuhn L, Mullins JI, Aldrovandi GM. PMID: 20422033; PMCID: PMC2857876.
4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms. PLoS One. 2010 Mar 23; 5(3):e9786. Nakamura KJ, Gach JS, Jones L, Semrau K, Walter J, Bibollet-Ruche F, Decker JM, Heath L, Decker WD, Sinkala M, Kankasa C, Thea D, Mullins J, Kuhn L, Zwick MB, Aldrovandi GM. PMID: 20352106; PMCID: PMC2843716.
Total body and spinal bone mineral density across Tanner stage in perinatally HIV-infected and uninfected children and youth in PACTG 1045. AIDS. 2010 Mar 13; 24(5):687-96. Jacobson DL, Lindsey JC, Gordon CM, Moye J, Hardin DS, Mulligan K, Aldrovandi GM, Pediatric AIDS Clinical Trials Group P1045 team. PMID: 20168204; PMCID: PMC3154736.
Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothers. Clin Infect Dis. 2010 Feb 01; 50(3):437-44. Kuhn L, Sinkala M, Semrau K, Kankasa C, Kasonde P, Mwiya M, Hu CC, Tsai WY, Thea DM, Aldrovandi GM. PMID: 20047479; PMCID: PMC2805776.
Obesity and dyslipidemia in behaviorally HIV-infected young women: Adolescent Trials Network study 021. Clin Infect Dis. 2010 Jan 01; 50(1):106-14. Mulligan K, Harris DR, Monte D, Stoszek S, Emmanuel P, Hardin DS, Kapogiannis BG, Worrell C, Meyer WA, Sleasman J, Wilson CM, Aldrovandi GM, Adolescent Trials Network 021 Protocol Team. PMID: 19947855; PMCID: PMC2939739.
HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission. J Int AIDS Soc. 2009 Dec 11; 12:36. Kuhn L, Sinkala M, Thea DM, Kankasa C, Aldrovandi GM. PMID: 20015345; PMCID: PMC2796993.
Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics. 2009 Dec; 124(6):e1189-97. Aldrovandi GM, Chu C, Shearer WT, Li D, Walter J, Thompson B, McIntosh K, Foca M, Meyer WA, Ha BF, Rich KC, Moye J. PMID: 19933732; PMCID: PMC2904486.
High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission. J Infect Dis. 2009 Nov 15; 200(10):1498-502. Walter J, Ghosh MK, Kuhn L, Semrau K, Sinkala M, Kankasa C, Thea DM, Aldrovandi GM. PMID: 19835475; PMCID: PMC2811259.
Intrapartum tenofovir and emtricitabine reduces low-concentration drug resistance selected by single-dose nevirapine for perinatal HIV prevention. AIDS Res Hum Retroviruses. 2009 Nov; 25(11):1099-106. Chi BH, Ellis GM, Chintu N, Cantrell RA, Sinkala M, Aldrovandi GM, Warrier R, Mbewe F, Nakamura K, Stringer EM, Frenkel LM, Stringer JS. PMID: 19886836; PMCID: PMC2828257.
Clean water helps but is not enough: challenges for safe replacement feeding of infants exposed to HIV. J Infect Dis. 2009 Oct 15; 200(8):1183-5. Kuhn L, Aldrovandi GM. PMID: 19758096; PMCID: PMC2904506.
Mortality and virologic outcomes after access to antiretroviral therapy among a cohort of HIV-infected women who received single-dose nevirapine in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2009 Sep 01; 52(1):132-6. Kuhn L, Semrau K, Ramachandran S, Sinkala M, Scott N, Kasonde P, Mwiya M, Kankasa C, Decker D, Thea DM, Aldrovandi GM. PMID: 19506483; PMCID: PMC2782481.
Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spots. J Clin Microbiol. 2009 Sep; 47(9):2989-91. Walter J, Kuhn L, Semrau K, Decker DW, Sinkala M, Kankasa C, Thea DM, Bulterys M, Ou CY, Aldrovandi GM. PMID: 19625479; PMCID: PMC2738105.
Differential effects of early weaning for HIV-free survival of children born to HIV-infected mothers by severity of maternal disease. PLoS One. 2009 Jun 26; 4(6):e6059. Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Kasonde P, Mwiya M, Tsai WY, Thea DM, Zambia Exclusive Breastfeeding Study (ZEBS). PMID: 19557167; PMCID: PMC2698120.
Growth faltering due to breastfeeding cessation in uninfected children born to HIV-infected mothers in Zambia. Am J Clin Nutr. 2009 Aug; 90(2):344-53. Arpadi S, Fawzy A, Aldrovandi GM, Kankasa C, Sinkala M, Mwiya M, Thea DM, Kuhn L. PMID: 19553300; PMCID: PMC2709311.
Morphologic and metabolic abnormalities in vertically HIV-infected children and youth. AIDS. 2009 Mar 27; 23(6):661-72. Aldrovandi GM, Lindsey JC, Jacobson DL, Zadzilka A, Sheeran E, Moye J, Borum P, Meyer WA, Hardin DS, Mulligan K, Pediatric AIDS Clinical Trials Group P1045 team. PMID: 19279441; PMCID: PMC2680185.
Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study. BMC Infect Dis. 2008 Dec 30; 8:172. Walter J, Kuhn L, Kankasa C, Semrau K, Sinkala M, Thea DM, Aldrovandi GM. PMID: 19116004; PMCID: PMC2630918.
Role of breastfeeding cessation in mediating the relationship between maternal HIV disease stage and increased child mortality among HIV-exposed uninfected children. Int J Epidemiol. 2009 Apr; 38(2):569-76. Fox MP, Brooks DR, Kuhn L, Aldrovandi G, Sinkala M, Kankasa C, Horsburgh R, Thea DM. PMID: 19047077; PMCID: PMC2734073.
Review of HIV antiretroviral drug resistance. Pediatr Infect Dis J. 2008 Aug; 27(8):749-52. Chen TK, Aldrovandi GM. PMID: 18664987; PMCID: PMC3909718.
Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors. Antimicrob Agents Chemother. 2008 Sep; 52(9):3276-83. Robbins BL, Capparelli EV, Chadwick EG, Yogev R, Serchuck L, Worrell C, Smith ME, Alvero C, Fenton T, Heckman B, Pelton SI, Aldrovandi G, Borkowsky W, Rodman J, Havens PL, PACTG 1038 Team. PMID: 18625762; PMCID: PMC2533475.
Diminished human immunodeficiency virus type 1 DNA yield from dried blood spots after storage in a humid incubator at 37 degrees C compared to -20 degrees C. J Clin Microbiol. 2008 Sep; 46(9):2945-9. Mitchell C, Jennings C, Brambilla D, Aldrovandi G, Amedee AM, Beck I, Bremer JW, Coombs R, Decker D, Fiscus S, Fitzgibbon J, Luzuriaga K, Moye J, Palumbo P, Reichelderfer P, Somasundaran M, Stevens W, Frenkel L, Dried Blood Spot Working Group of the Infant Maternal Pediatric Adolescent AIDS Clinical Trials Netw. PMID: 18614660; PMCID: PMC2546762.
Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med. 2008 Jul 10; 359(2):130-41. Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Mwiya M, Kasonde P, Scott N, Vwalika C, Walter J, Bulterys M, Tsai WY, Thea DM, Zambia Exclusive Breastfeeding Study. PMID: 18525036; PMCID: PMC2577610.
Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIV-infected children in Zambia. J Acquir Immune Defic Syndr. 2008 May 01; 48(1):90-6. Fox MP, Brooks D, Kuhn L, Aldrovandi G, Sinkala M, Kankasa C, Mwiya M, Horsburgh R, Thea DM. PMID: 18344878; PMCID: PMC2814597.
Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding. J Acquir Immune Defic Syndr. 2008 Mar 01; 47(3):320-8. Semrau K, Ghosh M, Kankasa C, Sinkala M, Kasonde P, Mwiya M, Thea DM, Kuhn L, Aldrovandi GM. PMID: 18398972; PMCID: PMC2821877.
Advances in basic science understanding of mother-to-child HIV-1 transmission. Curr Opin HIV AIDS. 2008 Mar; 3(2):146-50. Walter J, Kuhn L, Aldrovandi GM. PMID: 19372957.
High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission. PLoS One. 2007 Dec 26; 2(12):e1363. Kuhn L, Sinkala M, Kankasa C, Semrau K, Kasonde P, Scott N, Mwiya M, Vwalika C, Walter J, Tsai WY, Aldrovandi GM, Thea DM. PMID: 18159246; PMCID: PMC2137948.
Bystander effects: children who escape infection but not harm. J Acquir Immune Defic Syndr. 2007 Dec 15; 46(5):517-8. Kuhn L, Thea DM, Aldrovandi GM. PMID: 18043311; PMCID: PMC2803759.
Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet. 2007 Nov 17; 370(9600):1698-705. Chi BH, Sinkala M, Mbewe F, Cantrell RA, Kruse G, Chintu N, Aldrovandi GM, Stringer EM, Kankasa C, Safrit JT, Stringer JS. PMID: 17997151.
The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. PLoS One. 2007 Oct 03; 2(10):e969. Castelletti E, Lo Caputo S, Kuhn L, Borelli M, Gajardo J, Sinkala M, Trabattoni D, Kankasa C, Lauri E, Clivio A, Piacentini L, Bray DH, Aldrovandi GM, Thea DM, Veas F, Nebuloni M, Mazzotta F, Clerici M. PMID: 17912348; PMCID: PMC1989139.
Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission. J Acquir Immune Defic Syndr. 2007 Oct 01; 46(2):200-7. Walter J, Kuhn L, Ghosh MK, Kankasa C, Semrau K, Sinkala M, Mwiya M, Thea DM, Aldrovandi GM. PMID: 17667336; PMCID: PMC2803758.
Veterinary field test as screening tool for mastitis and HIV-1 viral load in breastmilk from HIV-infected Zambian women. Breastfeed Med. 2007 Sep; 2(3):172-5. Dorosko SM, Thea DM, Saperstein G, Russell RM, Paape MJ, Hinckley LS, Decker WD, Semrau K, Sinkala M, Kasonde P, Kankasa C, Aldrovandi GM, Hamer DH. PMID: 17903106; PMCID: PMC6701680.
Persistence of nevirapine in breast milk after discontinuation of treatment. Clin Infect Dis. 2007 Aug 01; 45(3):391-4. Bennetto-Hood C, Aldrovandi GM, King JR, Woodman K, Ashouri N, Acosta EP. PMID: 17599320.
Re: HIV-1 disease progression in breast-feeding and formula-feeding mothers: a prospective 2-year comparison of T cell subsets, HIV-1 RNA levels, and mortality. J Infect Dis. 2007 Jun 01; 195(11):1728-9; author reply 1729-30. Kuhn L, Thea DM, Aldrovandi GM. PMID: 17471447; PMCID: PMC3879046.
Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants. J Pediatr. 2006 Nov; 149(5):611-6. Kuhn L, Trabattoni D, Kankasa C, Sinkala M, Lissoni F, Ghosh M, Aldrovandi G, Thea D, Clerici M. PMID: 17095329; PMCID: PMC2811256.
Prevalence of primary HIV-1 drug resistance among recently infected adolescents: a multicenter adolescent medicine trials network for HIV/AIDS interventions study. J Infect Dis. 2006 Dec 01; 194(11):1505-9. Viani RM, Peralta L, Aldrovandi G, Kapogiannis BG, Mitchell R, Spector SA, Lie YS, Weidler JM, Bates MP, Liu N, Wilson CM, Adolescent Medicine Trials Network for HIV/AIDS Interventions. PMID: 17083034.
Reduction in preterm delivery and neonatal mortality after the introduction of antenatal cotrimoxazole prophylaxis among HIV-infected women with low CD4 cell counts. J Infect Dis. 2006 Dec 01; 194(11):1510-8. Walter J, Mwiya M, Scott N, Kasonde P, Sinkala M, Kankasa C, Kauchali S, Aldrovandi GM, Thea DM, Kuhn L. PMID: 17083035; PMCID: PMC1773010.
Violence and abuse among HIV-infected women and their children in Zambia: a qualitative study. J Nerv Ment Dis. 2006 Aug; 194(8):610-5. Murray LK, Haworth A, Semrau K, Singh M, Aldrovandi GM, Sinkala M, Thea DM, Bolton PA. PMID: 16909070; PMCID: PMC2811255.
Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume. AIDS. 2006 Jul 13; 20(11):1539-47. Thea DM, Aldrovandi G, Kankasa C, Kasonde P, Decker WD, Semrau K, Sinkala M, Kuhn L. PMID: 16847409; PMCID: PMC1773053.
Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency. J Clin Microbiol. 2006 Jul; 44(7):2612-4. Halvas EK, Aldrovandi GM, Balfe P, Beck IA, Boltz VF, Coffin JM, Frenkel LM, Hazelwood JD, Johnson VA, Kearney M, Kovacs A, Kuritzkes DR, Metzner KJ, Nissley DV, Nowicki M, Palmer S, Ziermann R, Zhao RY, Jennings CL, Bremer J, Brambilla D, Mellors JW. PMID: 16825395; PMCID: PMC1489464.
Nevirapine resistance viral mutations after repeat use of nevirapine for prevention of perinatal HIV transmission. J Acquir Immune Defic Syndr. 2006 Jun; 42(2):260-2. Kuhn L, Sinkala M, Kankasa MP, Kasonde P, Thea DM, Aldrovandi GM. PMID: 16760802; PMCID: PMC1773052.
Impact of chloroquine on viral load in breast milk. Trop Med Int Health. 2006 Jun; 11(6):800-3. Semrau K, Kuhn L, Kasonde P, Sinkala M, Kankasa C, Shutes E, Vwalika C, Ghosh M, Aldrovandi G, Thea DM. PMID: 16772000; PMCID: PMC1765922.
Vitamin D status in adolescents and young adults with HIV infection. Am J Clin Nutr. 2006 May; 83(5):1135-41. Stephensen CB, Marquis GS, Kruzich LA, Douglas SD, Aldrovandi GM, Wilson CM. PMID: 16685057.
Predictors of nonadherence to single-dose nevirapine therapy for the prevention of mother-to-child HIV transmission. J Acquir Immune Defic Syndr. 2006 Jan 01; 41(1):114-8. Albrecht S, Semrau K, Kasonde P, Sinkala M, Kankasa C, Vwalika C, Aldrovandi GM, Thea DM, Kuhn L. PMID: 16340483; PMCID: PMC1855628.
Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants? Clin Infect Dis. 2005 Dec 01; 41(11):1654-61. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Scott N, Tsai WY, Vermund SH, Aldrovandi GM, Thea DM. PMID: 16267740; PMCID: PMC1351118.
Prolonged breast-feeding and mortality up to two years post-partum among HIV-positive women in Zambia. AIDS. 2005 Oct 14; 19(15):1677-81. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Vwalika C, Tsai WY, Aldrovandi GM, Thea DM. PMID: 16184038; PMCID: PMC1393280.
Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in human immunodeficiency virus-infected children and adolescents: pediatric AIDS clinical trials group protocol 403. Pediatr Infect Dis J. 2005 Oct; 24(10):880-5. King JR, Nachman S, Yogev R, Hodge J, Aldrovandi G, Hughes MD, Chen J, Wiznia A, Damle B, Acosta EP. PMID: 16220085.
Model for assessment of proficiency of human immunodeficiency virus type 1 sequencing-based genotypic antiretroviral assays. J Clin Microbiol. 2005 Aug; 43(8):3963-70. Huang DD, Bremer JW, Brambilla DJ, Palumbo PE, Aldrovandi G, Eshleman S, Brown C, Fiscus S, Frenkel L, Hamdan H, Hart S, Kovacs A, Krogstad P, LaRussa P, Sullivan J, Weinberg A, Zhao YQ, Pediatric ACTG Sequencing Working Group. PMID: 16081937; PMCID: PMC1233968.
Alpha-defensins in the prevention of HIV transmission among breastfed infants. J Acquir Immune Defic Syndr. 2005 Jun 01; 39(2):138-42. Kuhn L, Trabattoni D, Kankasa C, Semrau K, Kasonde P, Lissoni F, Sinkala M, Ghosh M, Vwalika C, Aldrovandi GM, Thea DM, Clerici M. PMID: 15905728; PMCID: PMC1765920.
Women in couples antenatal HIV counseling and testing are not more likely to report adverse social events. AIDS. 2005 Mar 24; 19(6):603-9. Semrau K, Kuhn L, Vwalika C, Kasonde P, Sinkala M, Kankasa C, Shutes E, Aldrovandi G, Thea DM. PMID: 15802979; PMCID: PMC1201374.
Breast milk-derived antigen-specific CD8+ T cells: an extralymphoid effector memory cell population in humans. J Immunol. 2005 Mar 01; 174(5):2951-6. Sabbaj S, Ghosh MK, Edwards BH, Leeth R, Decker WD, Goepfert PA, Aldrovandi GM. PMID: 15728507.
CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides. AIDS. 2005 Feb 18; 19(3):241-50. Bansal A, Gough E, Sabbaj S, Ritter D, Yusim K, Sfakianos G, Aldrovandi G, Kaslow RA, Wilson CM, Mulligan MJ, Kilby JM, Goepfert PA. PMID: 15718834.
Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected children. Antivir Ther. 2005; 10(8):917-24. Viganò A, Aldrovandi GM, Giacomet V, Merlo M, Martelli L, Beretta S, Luraschi P, Rombolà G, Mora S. PMID: 16430197.
Pharmacokinetics of antiretrovirals administered to HIV-infected children via gastrostomy tube. HIV Clin Trials. 2004 Sep-Oct; 5(5):288-93. King JR, Yogev R, Aldrovandi G, Chadwick E, Acosta EP. PMID: 15562369.
Issues in the design of a clinical trial with a behavioral intervention–the Zambia exclusive breast-feeding study. Control Clin Trials. 2004 Aug; 25(4):353-65. Thea DM, Vwalika C, Kasonde P, Kankasa C, Sinkala M, Semrau K, Shutes E, Ayash C, Tsai WY, Aldrovandi G, Kuhn L. PMID: 15296810.
Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings. AIDS. 2004 Apr 09; 18(6):939-43. Stringer JS, Sinkala M, Goldenberg RL, Kumwenda R, Acosta EP, Aldrovandi GM, Stout JP, Vermund SH. PMID: 15060442; PMCID: PMC2745979.
Dynamics of HIV-1 recombination in its natural target cells. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4204-9. Levy DN, Aldrovandi GM, Kutsch O, Shaw GM. PMID: 15010526; PMCID: PMC384719.
HLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partners. AIDS Res Hum Retroviruses. 2004 Jan; 20(1):19-25. Tang J, Tang S, Lobashevsky E, Zulu I, Aldrovandi G, Allen S, Kaslow RA, Zambia-UAB HIV Research Project. PMID: 15000695.
Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine. AIDS. 2003 Jul 25; 17(11):1659-65. Stringer JS, Sinkala M, Chapman V, Acosta EP, Aldrovandi GM, Mudenda V, Stout JP, Goldenberg RL, Kumwenda R, Vermund SH. PMID: 12853748; PMCID: PMC2745973.
Quantitation of human immunodeficiency virus type 1 in breast milk. J Clin Microbiol. 2003 Jun; 41(6):2465-70. Ghosh MK, Kuhn L, West J, Semrau K, Decker D, Thea DM, Aldrovandi GM. PMID: 12791866; PMCID: PMC156553.
Multicenter evaluation of use of dried blood and plasma spot specimens in quantitative assays for human immunodeficiency virus RNA: measurement, precision, and RNA stability. J Clin Microbiol. 2003 May; 41(5):1888-93. Brambilla D, Jennings C, Aldrovandi G, Bremer J, Comeau AM, Cassol SA, Dickover R, Jackson JB, Pitt J, Sullivan JL, Butcher A, Grosso L, Reichelderfer P, Fiscus SA. PMID: 12734222; PMCID: PMC154666.
Evaluation of multiple drug therapy in human immunodeficiency virus-infected pediatric patients. Pediatr Infect Dis J. 2003 Mar; 22(3):239-44. King JR, Acosta EP, Chadwick E, Yogev R, Crain M, Pass R, Kimberlin DW, Sturdevant MS, Aldrovandi GM. PMID: 12634585.
Single-dose pharmacokinetics of enteric-coated didanosine in HIV-infected children. Antivir Ther. 2002 Dec; 7(4):267-70. King JR, Nachman S, Yogev R, Hodge J, Aldrovandi G, Damle B, Smith E, Wiznia A, Acosta EP. PMID: 12553481.
Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. J Virol. 2002 Aug; 76(16):8276-84. Tang J, Tang S, Lobashevsky E, Myracle AD, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow RA, Zambia-UAB HIV Research Project. PMID: 12134033; PMCID: PMC155130.
Human immunodeficiency virus-specific CD8(+) T cells in human breast milk. J Virol. 2002 Aug; 76(15):7365-73. Sabbaj S, Edwards BH, Ghosh MK, Semrau K, Cheelo S, Thea DM, Kuhn L, Ritter GD, Mulligan MJ, Goepfert PA, Aldrovandi GM. PMID: 12097549; PMCID: PMC136375.
Comparative analysis of commercial assays for the detection and quantification of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in plasma from patients infected with HIV-1 subtype C. Clin Infect Dis. 2002 Aug 01; 35(3):323-5. Hoesley CJ, Allen SA, Raper JL, Musonda R, Niu Y, Gao F, Squires KE, Aldrovandi GM. PMID: 12115099.
Antiretroviral pharmacokinetics in the paediatric population: a review. Clin Pharmacokinet. 2002; 41(14):1115-33. King JR, Kimberlin DW, Aldrovandi GM, Acosta EP. PMID: 12405863.
Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses. 2001 Jul 01; 17(10):901-10. Allen SA, Musonda R, Trask S, Hahn BH, Weiss H, Mulenga J, Kasolo F, Vermund SH, Aldrovandi GM. PMID: 11461676; PMCID: PMC2748905.
Mother-to-infant transmission of the human immunodeficiency virus during primary infection. N Engl J Med. 1999 Nov 11; 341(20):1548. Van Tine BA, Shaw GM, Aldrovandi G. PMID: 10577111.
Regions of human immunodeficiency virus type 1 nef required for function in vivo. J Virol. 1998 Sep; 72(9):7032-9. Aldrovandi GM, Gao L, Bristol G, Zack JA. PMID: 9696795; PMCID: PMC109923.
Human immunodeficiency virus inhibits multilineage hematopoiesis in vivo. J Virol. 1998 Jun; 72(6):5121-7. Koka PS, Fraser JK, Bryson Y, Bristol GC, Aldrovandi GM, Daar ES, Zack JA. PMID: 9573283; PMCID: PMC110080.
Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1. J Virol. 1997 Dec; 71(12):9817-22. Valentin A, Aldrovandi G, Zolotukhin AS, Cole SW, Zack JA, Pavlakis GN, Felber BK. PMID: 9371653; PMCID: PMC230297.
Loss of T cell receptor Vbeta repertoires in HIV type 1-infected SCID-hu mice. AIDS Res Hum Retroviruses. 1997 Jan 20; 13(2):125-34. Boldt-Houle DM, Jamieson BD, Aldrovandi GM, Rinaldo CR, Ehrlich GD, Zack JA. PMID: 9007198.
The SCID-hu mouse: an in-vivo model for HIV-1 pathogenesis and stem cell gene therapy for AIDS. Semin Immunol. 1996 Aug; 8(4):215-21. Jamieson BD, Aldrovandi GM, Zack JA. PMID: 8883144.
Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J Virol. 1996 Mar; 70(3):1505-11. Aldrovandi GM, Zack JA. PMID: 8627668; PMCID: PMC189971.
In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates. J Virol. 1995 Oct; 69(10):6259-64. Jamieson BD, Pang S, Aldrovandi GM, Zha J, Zack JA. PMID: 7666526; PMCID: PMC189523.
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol. 1994 Jun; 68(6):3478-85. Jamieson BD, Aldrovandi GM, Planelles V, Jowett JB, Gao L, Bloch LM, Chen IS, Zack JA. PMID: 8189487; PMCID: PMC236850.
The SCID-hu mouse as a model for HIV-1 infection. Nature. 1993 Jun 24; 363(6431):732-6. Aldrovandi GM, Feuer G, Gao L, Jamieson B, Kristeva M, Chen IS, Zack JA. PMID: 8515816.
