Tara TeSlaa
Research Interests:
metabolism, diabetes, muscle, fatty liver,Publications:
TeSlaa T. Metformin induces a Lac-Phe gut-brain signalling axis. Nat Metab. 2024 Mar 18. view on PubMed
McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. Glycine homeostasis requires reverse SHMT flux. Cell Metab. 2024 01 02; 36(1):103-115.e4. view on PubMed
Lu W, Park NR, TeSlaa T, Jankowski CSR, Samarah L, McReynolds M, Xing X, Schembri J, Woolf MT, Rabinowitz JD, Davidson SM. Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism. Anal Chem. 2023 10 10; 95(40):14879-14888. view on PubMed
TeSlaa T, Ralser M, Fan J, Rabinowitz JD. The pentose phosphate pathway in health and disease. Nat Metab. 2023 08; 5(8):1275-1289. view on PubMed
Zhang Z, TeSlaa T, Rabinowitz JD. Reply to: revisiting the role of serine metabolism in hepatic lipogenesis. Nat Metab. 2023 05; 5(5):762-764. view on PubMed
Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Vander Heiden MG, Herranz D, Guo JY, Kang Y, Rabinowitz JD. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023 02; 614(7947):349-357. view on PubMed
Yang L, TeSlaa T, Ng S, Nofal M, Wang L, Lan T, Zeng X, Cowan A, McBride M, Lu W, Davidson S, Liang G, Oh TG, Downes M, Evans R, Von Hoff D, Guo JY, Han H, Rabinowitz JD. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med. 2022 02 11; 3(2):119-136. view on PubMed
Wang L, Xing X, Zeng X, Jackson SR, TeSlaa T, Al-Dalahmah O, Samarah LZ, Goodwin K, Yang L, McReynolds MR, Li X, Wolff JJ, Rabinowitz JD, Davidson SM. Spatially resolved isotope tracing reveals tissue metabolic activity. Nat Methods. 2022 02; 19(2):223-230. view on PubMed
Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz GJ, Clasquin MF, Rabinowitz JD. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021 12; 3(12):1608-1620. view on PubMed
Bartman CR, TeSlaa T, Rabinowitz JD. Quantitative flux analysis in mammals. Nat Metab. 2021 07; 3(7):896-908. view on PubMed
TeSlaa T, Bartman CR, Jankowski CSR, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz JD. The Source of Glycolytic Intermediates in Mammalian Tissues. Cell Metab. 2021 02 02; 33(2):367-378.e5. view on PubMed
Quinn WJ, Jiao J, TeSlaa T, Stadanlick J, Wang Z, Wang L, Akimova T, Angelin A, Schäfer PM, Cully MD, Perry C, Kopinski PK, Guo L, Blair IA, Ghanem LR, Leibowitz MS, Hancock WW, Moon EK, Levine MH, Eruslanov EB, Wallace DC, Baur JA, Beier UH. Lactate Limits T Cell Proliferation via the NAD(H) Redox State. Cell Rep. 2020 12 15; 33(11):108500. view on PubMed
Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020 10 06; 32(4):676-688.e4. view on PubMed
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 07; 16(7):731-739. view on PubMed
Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. 2019 12 05; 25(6):830-845.e8. view on PubMed
Shimada E, Ahsan FM, Nili M, Huang D, Atamdede S, TeSlaa T, Case D, Yu X, Gregory BD, Perrin BJ, Koehler CM, Teitell MA. PNPase knockout results in mtDNA loss and an altered metabolic gene expression program. PLoS One. 2018; 13(7):e0200925. view on PubMed
TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA. α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells. Cell Metab. 2016 09 13; 24(3):485-493. view on PubMed
Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D, Koehler CM, Graeber TG, Chiou PY, Teitell MA. Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Cell Metab. 2016 05 10; 23(5):921-9. view on PubMed
TeSlaa T, Setoguchi K, Teitell MA. Mitochondria in human pluripotent stem cell apoptosis. Semin Cell Dev Biol. 2016 Apr; 52:76-83. view on PubMed
Setoguchi K, TeSlaa T, Koehler CM, Teitell MA. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. J Mol Biol. 2016 Apr 10; 428(7):1465-75. view on PubMed
Teslaa T, Teitell MA. Pluripotent stem cell energy metabolism: an update. EMBO J. 2015 Jan 13; 34(2):138-53. view on PubMed
Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. view on PubMed
TeSlaa T, Teitell MA. Techniques to monitor glycolysis. Methods Enzymol. 2014; 542:91-114. view on PubMed
Xu J, Teslaa T, Wu TH, Chiou PY, Teitell MA, Weiss S. Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells. Nano Lett. 2012 Nov 14; 12(11):5669-72. view on PubMed
Wu TH, Chen Y, Park SY, Hong J, Teslaa T, Zhong JF, Di Carlo D, Teitell MA, Chiou PY. Pulsed laser triggered high speed microfluidic fluorescence activated cell sorter. Lab Chip. 2012 Apr 07; 12(7):1378-83. view on PubMed
French CT, Toesca IJ, Wu TH, Teslaa T, Beaty SM, Wong W, Liu M, Schröder I, Chiou PY, Teitell MA, Miller JF. Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12095-100. view on PubMed
Wu TH, Teslaa T, Kalim S, French CT, Moghadam S, Wall R, Miller JF, Witte ON, Teitell MA, Chiou PY. Photothermal nanoblade for large cargo delivery into mammalian cells. Anal Chem. 2011 Feb 15; 83(4):1321-7. view on PubMed
Wu TH, Teslaa T, Teitell MA, Chiou PY. Photothermal nanoblade for patterned cell membrane cutting. Opt Express. 2010 Oct 25; 18(22):23153-60. view on PubMed
