Lydia Daboussi*

Lydia Daboussi, Ph.D.

Office Address:
CHS 63-170


Assistant Professor, Neurobiology

Research Interests

A central challenge in neuroscience centers upon promoting nervous system regeneration. However, nervous system recovery after injury and during disease is often studied from a ‘neuron-centric’ perspective. This approach overlooks the interplay between neurons and glia, which facilitate neuronal function. Schwann cells, a type of peripheral glia, engage conserved cytoplasmic to nuclear signaling pathways to promote axonal myelination, and neural regeneration. The Daboussi lab integrates cell biology, protein biochemistry, and microscopy with mouse models human disease to understand how Schwann cells are affected by – and react to- peripheral nerve disease and injury.


A selected list of publications:


Live Cell Imaging of Yeast Golgi Dynamics. Methods Mol Biol. 2023; 2557:3-15. Costaguta G, Payne GSDaboussi L. PMID: 36512205.
Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3433-3438. Daboussi L, Costaguta G, Ghukasyan R, Payne GS. PMID: 28289207; PMCID: PMC5380026.
Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. Mol Biol Cell. 2012 Nov; 23(22):4416-29. Gorynia S, Lorenz TC, Costaguta G, Daboussi LCascio DPayne GS. PMID: 22993212; PMCID: PMC3496615
Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. Nat Cell Biol. 2012 Feb 19; 14(3):239-48. Daboussi L, Costaguta G, Payne GS. PMID: 22344030; PMCID: PMC4855891 
Genome-wide analysis of AP-3-dependent protein transport in yeast. Mol Biol Cell. 2009 Mar; 20(5):1592-604. Anand VC, Daboussi L, Lorenz TC, Payne GS. PMID: 19116312; PMCID: PMC2649279.