Jocelyn Kim

Jocelyn Kim, M.D.

Office Address:
CHS 52-215


Assistant Clinical Professor, Infectious Diseases

Research Interests

Millions of people continue to live with HIV/AIDS and are part of the global epidemic. Antiretroviral therapy (ART) can suppress but not cure HIV infection, mainly because of the persistence of infected cells. These cells arise from the ability of HIV to integrate its viral genome into the host cell’s chromosomes and remain quiescent and elude the immune system. This reservoir of latently infected cells is the most formidable obstacle to curing HIV. Our research interests focus on developing approaches to eliminating latently infected cells. One approach is to use a “kick and kill” strategy, in which latent cells are induced to produce viral proteins by a latency reversing agent. However, latency reversing agents by themselves may not be able to eliminate the viral reservoir, thus we have also been developing effector immune cells supercharged to rapidly kill infected cells as they emerge from latency. We have extensive experience in developing humanized mouse models of HIV infection. In addition, we utilize virus barcoding technology in order to track and quantify viral and cellular clones of the viral reservoir by deep sequencing. Our overall goal is to deliver effective therapies for HIV eradication and advance toward clinical evaluation.


A selected list of publications:

A humanized mouse model to study NK cell biology during HIV infection. J Clin Invest. 2022 12 15; 132(24). Kim JTZack JA. PMID: 36519544; PMCID: PMC9753985.
Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention. Stem Cell Res Ther. 2022 03 21; 13(1):112. Li YR, Dunn ZS, Garcia G, Carmona C, Zhou Y, Lee D, Yu J, Huang J, Kim JTArumugaswami V, Wang P, Yang L. PMID: 35313965; PMCID: PMC8935266.
Latency reversal plus natural killer cells diminish HIV reservoir in vivo. Nat Commun. 2022 01 10; 13(1):121. Kim JT, Zhang TH, Carmona C, Lee B, Seet CS, Kostelny M, Shah N, Chen H, Farrell K, Soliman MSA, Dimapasoc M, Sinani M, Blanco KYR, Bojorquez D, Jiang H, Shi Y, Du Y, Komarova NL, Wodarz D, Wender PA, Marsden MD, Sun R, Zack JA. PMID: 35013215; PMCID: PMC8748509.
HLA-A*02:01 restricted T�cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses. Cell Rep. 2021 12 28; 37(13):110167. Nesterenko PA, McLaughlin J, Tsai BL, Burton Sojo G, Cheng D, Zhao D, Mao Z, Bangayan NJ, Obusan MB, Su Y, Ng RH, Chour W, Xie J, Li YR, Lee D, Noguchi M, Carmona C, Phillips JW, Kim JT, Yang L, Heath JR, Boutros PCWitte ON. PMID: 34919800; PMCID: PMC8660260
Tracking HIV Rebound following Latency Reversal Using Barcoded HIV. Cell Rep Med. 2020 12 22; 1(9):100162. Marsden MD, Zhang TH, Du Y, Dimapasoc M, Soliman MSA, Wu X, Kim JT, Shimizu A, Schrier A, Wender PA, Sun R, Zack JA. PMID: 33377133; PMCID: PMC7762775
Occult Colonic Perforation in a Patient With Coronavirus Disease 2019 After Interleukin-6 Receptor Antagonist Therapy. Open Forum Infect Dis. 2020 Nov; 7(11):ofaa424. Schwab KHamidi S, Chung A, Lim RJ, Khanlou N, Hoesterey D, Dumitras C, Adeyiga OB, Phan-Tang M, Wang TSSaggar R, Goldstein J, Belperio JADubinett SMKim JTSalehi-Rad R. PMID: 33204749; PMCID: PMC7543619
Pharmacological Activation of Non-canonical NF-?B Signaling Activates Latent HIV-1 Reservoirs In�Vivo. Cell Rep Med. 2020 06 23; 1(3):100037. Pache L, Marsden MD, Teriete P, Portillo AJ, Heimann D, Kim JT, Soliman MSA, Dimapasoc M, Carmona C, Celeridad M, Spivak AM, Planelles V, Cosford NDP, Zack JA, Chanda SK. PMID: 33205060; PMCID: PMC7659604
T cell antigen discovery via trogocytosis. Nat Methods. 2019 02; 16(2):183-190. Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas AWitte ON, Baltimore D. PMID: 30700903; PMCID: PMC6719556
Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation. Sci Immunol. 2017 Jul 21; 2(13). Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D. PMID: 28733470; PMCID: PMC5845465
Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping. Sci Rep. 2016 08 08; 6:30736. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A, Kulkarni RP. PMID: 27498769; PMCID: PMC4976371
A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera. PLoS One. 2013; 8(10):e76224. Pfeilsticker JA, Umeda A, Farrow B, Hsueh CL, Deyle KM, Kim JT, Lai BT, Heath JR. PMID: 24116098; PMCID: PMC3792125
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature. 2011 Aug 17; 477(7362):95-8. Sigal A, Kim JT, Balazs AB, Dekel E, Mayo A, Milo R, Baltimore D. PMID: 21849975.