Danielle Schmitt*

Publications:

Jhawar A, Parks K, Schmitt DL. Illuminating compartmentalized AMPK signaling in single cells. Biochem J. 2026 Jun 03; 483(6):849-860. view on PubMed

Lee REC, Yeung J, Mumford T, Bugaj L, Daniels MJ, Stanley J, Pourmand N, Vineall KG, Schmitt DL, Rahman SMT, Sung MH. Noninvasive methods to monitor dynamic single-cell events. Trends Cell Biol. 2026 Apr 14. view on PubMed

Vineall KG, Andrikopoulos A, Sun MJ, Yan A, Hartanto ER, Schmitt DL. Visualizing PINK1 Activity Dynamics in Single Cells with a Phase Separation-Based Kinase Activity Reporter. ACS Sens. 2026 Feb 27; 11(2):1517-1526. view on PubMed

Scully JM, Sun MJ, Das S, Arias NJ, Kapelczak ED, Robinson TD, Vineall KG, Dean TS, TeSlaa T, Divakaruni AS, Schmitt DL. Illuminating spatial dynamics of glutamine metabolism with a sensitive genetically encoded biosensor. bioRxiv. 2026 Jan 16. view on PubMed

Parks K, Jhawar A, Andrikopoulos A, Winters DM, Dean TS, Kapelczak ED, TeSlaa T, Bouhaddou M, Schmitt DL. Spatial regulation of AMPK activity under oxidative stress requires LKB1. bioRxiv. 2025 Nov 17. view on PubMed

Brennan PJ, Saunders RE, Spanou M, Singleton SE, Serafini M, Sun L, Heger GP, Konopacka A, Beveridge RD, Taylor CC, DePaola P, Gordon L, Bunally SB, Saudemont A, Benowitz AB, Martinez-Fleites C, Schmitt DL, Damoiseaux R, Queisser MA, An H, Deane CM, Hann MM, Brayshaw LL, Conway SJ. Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells. ACS Chem Biol. 2025 11 21; 20(11):2827-2843. view on PubMed

Vineall KG, Andrikopoulos A, Sun MJ, Yan A, Hartanto ER, Schmitt DL. Visualizing PINK1 Activity Dynamics in Single Cells with a Phase Separation-Based Kinase Activity Reporter. bioRxiv. 2025 Oct 16. view on PubMed

Ranzau BL, Robinson TD, Scully JM, Kapelczak ED, Dean TS, TeSlaa T, Schmitt DL. A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA. ACS Bio Med Chem Au. 2025 Feb 19; 5(1):184-193. view on PubMed

Ranzau BL, Robinson TD, Scully JM, Kapelczack ED, Dean TS, TeSlaa T, Schmitt DL. A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA. bioRxiv. 2024 Sep 28. view on PubMed

Jeon M, Schmitt DL, Kyoung M, An S. Size-Specific Modulation of a Multienzyme Glucosome Assembly during the Cell Cycle. ACS Bio Med Chem Au. 2023 Oct 18; 3(5):461-470. view on PubMed

Schmitt DL, Dranchak P, Parajuli P, Blivis D, Voss T, Kohnhorst CL, Kyoung M, Inglese J, An S. High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells. PLoS One. 2023; 18(8):e0289707. view on PubMed

Schmitt DL. Imaging Subcellular AMPK Activity Using an Excitation-Ratiometric AMPK Activity Reporter. Curr Protoc. 2023 May; 3(5):e771. view on PubMed

Liu L, Wang Y, Schmitt DL. LUNAS: A Rapid and Sensitive Nucleic Acid Detection Assay Using Split NanoLuc Luciferase Complementation. ACS Cent Sci. 2023 Apr 26; 9(4):593-596. view on PubMed

Peng Q, Huang Z, Sun K, Liu Y, Yoon CW, Harrison RES, Schmitt DL, Zhu L, Wu Y, Tasan I, Zhao H, Zhang J, Zhong S, Chien S, Wang Y. Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Nat Commun. 2022 12 24; 13(1):7933. view on PubMed

Schmitt DL, Mehta S, Zhang J. Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools. Curr Opin Chem Biol. 2022 12; 71:102224. view on PubMed

Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nat Commun. 2022 07 05; 13(1):3856. view on PubMed

Schmitt DL, Mehta S, Zhang J. Illuminating the kinome: Visualizing real-time kinase activity in biological systems using genetically encoded fluorescent protein-based biosensors. Curr Opin Chem Biol. 2020 02; 54:63-69. view on PubMed

Ohadi D, Schmitt DL, Calabrese B, Halpain S, Zhang J, Rangamani P. Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines. Biophys J. 2019 11 19; 117(10):1963-1980. view on PubMed

Schmitt DL, Sundaram A, Jeon M, Luu BT, An S. Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways. PLoS One. 2018; 13(4):e0195989. view on PubMed

Schmitt DL, An S. Spatial Organization of Metabolic Enzyme Complexes in Cells. Biochemistry. 2017 06 27; 56(25):3184-3196. view on PubMed

Schmitt DL, Cheng YJ, Park J, An S. Sequestration-Mediated Downregulation of de Novo Purine Biosynthesis by AMPK. ACS Chem Biol. 2016 07 15; 11(7):1917-24. view on PubMed