Daria Siekhaus
Publications:
Siekhaus DE, Stanley-Ahmed JA. Discovering mechanisms of macrophage tissue infiltration with Drosophila. Curr Opin Immunol. 2024 Dec; 91:102502. view on PubMed
Boytsov D, Madej GM, Horn G, Blaha N, Köcher T, Sitte HH, Siekhaus D, Ziegler C, Sandtner W, Roblek M. Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. Proc Natl Acad Sci U S A. 2024 Mar 26; 121(13):e2319686121. view on PubMed
Nagano M, Aoshima K, Shimamura H, Siekhaus DE, Toshima JY, Toshima J. Distinct role of TGN-resident clathrin adaptors for Vps21p activation in the TGN-endosome trafficking pathway. J Cell Sci. 2023 09 01; 136(17). view on PubMed
Toshima JY, Tsukahara A, Nagano M, Tojima T, Siekhaus DE, Nakano A, Toshima J. The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network. Elife. 2023 07 21; 12. view on PubMed
Enshoji M, Miyano Y, Yoshida N, Nagano M, Watanabe M, Kunihiro M, Siekhaus DE, Toshima JY, Toshima J. Eps15/Pan1p is a master regulator of the late stages of the endocytic pathway. J Cell Biol. 2022 10 03; 221(10). view on PubMed
Akhmanova M, Emtenani S, Krueger D, Gyoergy A, Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. Cell division in tissues enables macrophage infiltration. Science. 2022 04 22; 376(6591):394-396. view on PubMed
Martin ET, Blatt P, Nguyen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani S, Siekhaus DE, Berman A, Fuchs G, Rangan P. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Dev Cell. 2022 04 11; 57(7):883-900.e10. view on PubMed
Emtenani S, Martin ET, Gyoergy A, Bicher J, Genger JW, Köcher T, Akhmanova M, Guarda M, Roblek M, Bergthaler A, Hurd TR, Rangan P, Siekhaus DE. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. EMBO J. 2022 06 14; 41(12):e109049. view on PubMed
Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis. Front Oncol. 2022; 12:777634. view on PubMed
Belyaeva V, Wachner S, Gyoergy A, Emtenani S, Gridchyn I, Akhmanova M, Linder M, Roblek M, Sibilia M, Siekhaus D. Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila. PLoS Biol. 2022 01; 20(1):e3001494. view on PubMed
Ingles-Prieto A, Furthmann N, Crossman SH, Tichy AM, Hoyer N, Petersen M, Zheden V, Biebl J, Reichhart E, Gyoergy A, Siekhaus DE, Soba P, Winklhofer KF, Janovjak H. Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet. 2021 04; 17(4):e1009479. view on PubMed
Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, Gyoergy A, Groß O, Siekhaus DE, Dionne MS. Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. Elife. 2020 01 20; 9. view on PubMed
Nagano M, Toshima JY, Siekhaus DE, Toshima J. Rab5-mediated endosome formation is regulated at the trans-Golgi network. Commun Biol. 2019; 2:419. view on PubMed
Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, Ratheesh A, Reis-Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Elife. 2019 03 26; 8. view on PubMed
Trébuchet G, Cattenoz PB, Zsámboki J, Mazaud D, Siekhaus DE, Fanto M, Giangrande A. The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate. J Neurosci. 2019 01 09; 39(2):238-255. view on PubMed
Ratheesh A, Biebl J, Vesela J, Smutny M, Papusheva E, Krens SFG, Kaufmann W, Gyoergy A, Casano AM, Siekhaus DE. Drosophila TNF Modulates Tissue Tension in the Embryo to Facilitate Macrophage Invasive Migration. Dev Cell. 2018 05 07; 45(3):331-346.e7. view on PubMed
Gyoergy A, Roblek M, Ratheesh A, Valoskova K, Belyaeva V, Wachner S, Matsubayashi Y, Sánchez-Sánchez BJ, Stramer B, Siekhaus DE. Tools Allowing Independent Visualization and Genetic Manipulation of Drosophila melanogaster Macrophages and Surrounding Tissues. G3 (Bethesda). 2018 03 02; 8(3):845-857. view on PubMed
Yamamoto W, Wada S, Nagano M, Aoshima K, Siekhaus DE, Toshima JY, Toshima J. Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast. J Cell Sci. 2018 01 04; 131(1). view on PubMed
Matsubayashi Y, Louani A, Dragu A, Sánchez-Sánchez BJ, Serna-Morales E, Yolland L, Gyoergy A, Vizcay G, Fleck RA, Heddleston JM, Chew TL, Siekhaus DE, Stramer BM. A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation. Curr Biol. 2017 Nov 20; 27(22):3526-3534.e4. view on PubMed
Toshima JY, Furuya E, Nagano M, Kanno C, Sakamoto Y, Ebihara M, Siekhaus DE, Toshima J. Yeast Eps15-like endocytic protein Pan1p regulates the interaction between endocytic vesicles, endosomes and the actin cytoskeleton. Elife. 2016 Feb 25; 5. view on PubMed
Toshima JY, Horikomi C, Okada A, Hatori MN, Nagano M, Masuda A, Yamamoto W, Siekhaus DE, Toshima J. Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis. J Cell Sci. 2016 Jan 15; 129(2):367-79. view on PubMed
Ratheesh A, Belyaeva V, Siekhaus DE. Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. Curr Opin Cell Biol. 2015 Oct; 36:71-9. view on PubMed
Kawada D, Kobayashi H, Tomita T, Nakata E, Nagano M, Siekhaus DE, Toshima JY, Toshima J. The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins. Biochim Biophys Acta. 2015 Jan; 1853(1):144-56. view on PubMed
Toshima JY, Nishinoaki S, Sato Y, Yamamoto W, Furukawa D, Siekhaus DE, Sawaguchi A, Toshima J. Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole. Nat Commun. 2014 Mar 25; 5:3498. view on PubMed
DeGennaro M, Hurd TR, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Dev Cell. 2011 Feb 15; 20(2):233-43. view on PubMed
Siekhaus D, Haesemeyer M, Moffitt O, Lehmann R. RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila. Nat Cell Biol. 2010 Jun; 12(6):605-10. view on PubMed
Kunwar PS, Siekhaus DE, Lehmann R. In vivo migration: a germ cell perspective. Annu Rev Cell Dev Biol. 2006; 22:237-65. view on PubMed
Siekhaus DE, Drubin DG. Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant. Nat Cell Biol. 2003 Mar; 5(3):231-5. view on PubMed
Rayburn LY, Gooding HC, Choksi SP, Maloney D, Kidd AR, Siekhaus DE, Bender M. amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Genetics. 2003 Jan; 163(1):227-37. view on PubMed
Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. J Biol Chem. 2000 Jun 09; 275(23):17886-93. view on PubMed
Siekhaus DE, Fuller RS. A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. J Neurosci. 1999 Aug 15; 19(16):6942-54. view on PubMed
