Jeannette is studying the structure of amyloid proteins using x-ray crystallography and other biophysical methods. She is currently focusing on alpha-synuclein and its interaction with cell membranes.
Mechanism of Xist induced X chromosome inactivation during differentiation of female mouse embryonic stem cells.
William Deng (Weixian)
Lisa researches sex differences in Multiple Sclerosis by studying sex chromosome effects on the immune system and central nervous system.
The importance of studying sex differences in disease: The example of multiple sclerosis. Golden LC, Voskuhl R. J Neurosci Res. 2017 Jan 2;95(1-2):633-643. doi: 10.1002/jnr.23955. Review.
Mimi Ho (Chi-Min)
Mimi studies the structure and function of membrane protein complexes using biochemistry and cryo-EM.
Xuchen is understanding the role of GPIHBP1 in triglyceride metabolism and investigating the mechanism of cholesterol transport in macrophages.
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. J Clin Lipidol. 2017 Jun 13. pii: S1933-2874(17)30344-6. doi: 10.1016/j.jacl.2017.05.017. [Epub ahead of print]
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. N Engl J Med. 2017 Apr 27;376(17):1647-1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5.
High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2000-2005. doi: 10.1073/pnas.1621432114. Epub 2017 Feb 6.
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15.
An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. J Lipid Res. 2016 Oct;57(10):1889-1898. Epub 2016 Aug 5.
Eric is developing a next-generation platform for screening G protein-coupled receptor activity.
Structure-based design of functional amyloid materials. Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS. J Am Chem Soc. 2014 Dec 31;136(52):18044-51. doi: 10.1021/ja509648u. Epub 2014 Dec 19.
Joshua’s research is focused on designing and characterizing self-assembling protein materials.
The design of symmetric protein nanomaterials comes of age in theory and practice. Yeates TO, Liu Y, Laniado J. Curr Opin Struct Biol. 2016 Aug;39:134-143. doi: 10.1016/j.sbi.2016.07.003. Epub 2016 Jul 29. Review.
Calvin is defining molecular functions of the lymphocyte Antigens SLURP 1 and SLURP 2 in Keratinocytes.
Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP. J Biol Chem. 2014 Jul 11;289(28):19491-9. doi: 10.1074/jbc.M114.558528. Epub 2014 May 20.
Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter. Turlo K, Leung CS, Seo JJ, Goulbourne CN, Adeyo O, Gin P, Voss C, Bensadoun A, Fong LG, Young SG, Beigneux AP. Biochim Biophys Acta. 2014 Jul;1841(7):963-9. doi: 10.1016/j.bbalip.2014.03.011. Epub 2014 Apr 2.
A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, Beigneux AP. Biochim Biophys Acta. 2014 Jul;1841(7):970-6. doi: 10.1016/j.bbalip.2014.03.008. Epub 2014 Mar 28.
High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population. Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J. J Biol Chem. 2014 May 2;289(18):12566-77. doi: 10.1074/jbc.M113.497438. Epub 2014 Mar 13
Han Young Lim
Hanyoung researches the complex protein interactions that occur during alternative splicing events involving PTBs.
Andrew is researching the function of HIV Vpr in the context of DNA Damage Response.
Development of computational models for amyloid protein structure and dynamics
Jessica researches the design and synthesis of Supramolecular Protein Structures.
Aanand is researching mechanisms of formin-mediated actin assembly. His work is focused on the formin FHOD, which plays important roles in cell motility and sarcomere organization.
Lauren Thurlow studies the mechanisms behind the dramatic changes in gene expression and RNA processing that occur during stress responses in yeast.
Jerrell researches how to enhance MRI image contrast with ferritin genes in RNA replicon form.
Meaghan is working on developing a method for the biosynthetic production of paclitaxel
Brian is exploring how ubiquitination can regulate cellular signaling.
DNA Damage Regulates Translation through β-TRCP Targeting of CReP. Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP. PLoS Genet. 2015 Jun 19;11(6):e1005292. doi: 10.1371/journal.pgen.1005292. eCollection 2015 Jun.