Yang Kevin Xiang
Our lab investigates diabetes and metabolic disorders, focusing on their links to cardiovascular and neurodegenerative diseases. Using tools ranging from single-molecule imaging to whole-animal genetic models, we aim to uncover mechanisms and develop innovative therapies for conditions such as diabetes, heart failure, and Alzheimer’s disease.
Websites:
Research Interests:
neurohormonal regulation, Alzheimer's disease, Diabetes and metabolic disorders, Heart failure with preserved ejection fraction,Publications:
Lado-Abeal J, Munir I, Al-Zubaidi K, Mohammed S, Tadisina S, Stiewig-Rapp MJ, Arvandi A, Whisenant T, Ginzo-Villamayor MJ, Tejera-Perez C, Perez-Castro P, Fernandez-Rodriguez E, Guo A, Surampudi P, Bhattacharya R, Xiang YK, Smith TW, Fernandez-Pombo A. Heart ventricular function in hospitalized patients with severe hypothyroidism and myxedema coma. J Clin Endocrinol Metab. 2026 Jun 17; 111(7):2016-2026. view on PubMed
Man KNM, Rougé SLS, Berumen RA, Jacobi AA, Weiner JC, Naderi SY, Ireton KE, Estrada-Tobar ZM, Zeng Z, Martinez JM, Xiang YK, Nieves-Cintrón M, Navedo MF, Bartels P, Horne MC, Hell JW. Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory. Sci Signal. 2025 Dec 09; 18(916):eadp7760. view on PubMed
Han Y, Rouen KC, Yarov-Yarovoy V, Clancy CE, Xiang YK, Vorobyov I, Ahn SH. Ligand Dissociation Pathways from Membrane Receptors Revealed by Weighted Ensemble Simulations. J Phys Chem B. 2025 10 23; 129(42):10945-10955. view on PubMed
Zhu C, Zhao M, Zhao L, Wu M, Xiang YK. Cardiac β2 adrenergic receptor deletion drives calmodulin kinase II upregulation to induce connective tissue growth factor in cardiac fibrosis and diastolic dysfunction. Function (Oxf). 2025 09 15; 6(5). view on PubMed
Lee B, Xing X, Hammes EA, Zeng Z, Estrada-Tobar ZM, Kim K, Ireton KE, Mimi Man KN, Jacobi AA, Berumen RA, Weiner JC, Shen A, Xu B, Wang J, Gasser PJ, Navedo MF, Xiang YK, Díaz E, Chen CY, Horne MC, Hell JW. Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity. Cell Rep. 2025 Aug 26; 44(8):116011. view on PubMed
Hong J, Martín-Aragón Baudel M, Niloy SI, Taylor J, Mohabbat Y, Moustafa Y, Pereira Da Silva E, O'Donnell BL, Zhu Z, Daghbouche-Rubio N, Reddy GR, Sasse KC, Ward SM, Xiang YK, Isakson BE, Nieves-Cintrón M, Navedo MF. Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia. Circ Res. 2025 Aug 15; 137(5):646-663. view on PubMed
Liu X, Cai YD, Hou C, Liu X, Luo Y, Mendiola AJP, Xu X, Luo Y, Zheng H, Zhao C, Chen CH, Zhang Y, Xiang YK, Ma J, Chiu JC. Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression. bioRxiv. 2025 Jun 19. view on PubMed
Yee C, Xiao Y, Chen H, Reddy AR, Xu B, Medwig-Kinney TN, Zhang W, Boyle AP, Herbst WA, Xiang YK, Matus DQ, Shen K. Author Correction: An activity-regulated transcriptional program directly drives synaptogenesis. Nat Neurosci. 2025 May; 28(5):1108. view on PubMed
Cho JM, Vu K, Park SK, Zhu E, Li YR, Zhao P, Yokota T, Yang L, Lu R, Xiang YK, Shen YH, Chapleau MW, Hsiai TK. Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness. Circ Res. 2025 Jun 06; 136(12):1579-1594. view on PubMed
Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK. Structure and dynamics determine G protein coupling specificity at a class A GPCR. Sci Adv. 2025 Mar 21; 11(12):eadq3971. view on PubMed
Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, Li P, Wu X, Wendland MF, Lin K, Chen WC, Choksi SP, Chen G, Holtzman MJ, Reiter JF, Wan Y, Xuan Z, Xiang YK, Xu CS, Upadhyayula S, Hess HF, He L. Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions. Cell Rep. 2025 Mar 25; 44(3):115383. view on PubMed
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Structure and dynamics determine G protein coupling specificity at a class A GPCR. bioRxiv. 2025 Jan 31. view on PubMed
Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, Li P, Wu X, Wendland MF, Lin K, Chen WC, Choksi SP, Chen G, Holtzman MJ, Reiter JF, Wan Y, Xuan Z, Xiang YK, Xu CS, Upadhyayula S, Hess HF, He L. Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions. bioRxiv. 2025 Jan 22. view on PubMed
Han Y, Dawson JRD, DeMarco KR, Rouen KC, Ngo K, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Ahn SH, Vorobyov I. Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein. iScience. 2025 Feb 21; 28(2):111741. view on PubMed
Zhu Z, Guan Q, Xu B, Bahriz S, Shen A, West TM, Zhang Y, Deng B, Wei W, Han Y, Wang Q, Xiang YK. Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy. Br J Pharmacol. 2025 Apr; 182(7):1487-1507. view on PubMed
Yee C, Xiao Y, Chen H, Reddy AR, Xu B, Medwig-Kinney TN, Zhang W, Boyle AP, Herbst WA, Xiang YK, Matus DQ, Shen K. An activity-regulated transcriptional program directly drives synaptogenesis. Nat Neurosci. 2024 Sep; 27(9):1695-1707. view on PubMed
Xu B, Bahriz S, Salemme VR, Wang Y, Zhu C, Zhao M, Xiang YK. Differential Downregulation of β1-Adrenergic Receptor Signaling in the Heart. J Am Heart Assoc. 2024 06 18; 13(12):e033733. view on PubMed
Wang Y, Zhao M, Liu X, Xu B, Reddy GR, Jovanovic A, Wang Q, Zhu C, Xu H, Bayne EF, Xiang W, Tilley DG, Ge Y, Tate CG, Feil R, Chiu JC, Bers DM, Xiang YK. Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure. JACC Basic Transl Sci. 2024 Aug; 9(8):982-1001. view on PubMed
Nayak TK, Bajpai A, Patwa V, Carter RL, Enjamuri N, Gao E, Xiang YK, Tilley DG. Loss of Myeloid Cell-Specific β2-Adrenergic Receptor Expression Ameliorates Cardiac Function and Remodeling after Acute Ischemia. bioRxiv. 2023 Nov 27. view on PubMed
Fu Q, Wang Y, Yan C, Xiang YK. Phosphodiesterase in heart and vessels: from physiology to diseases. Physiol Rev. 2024 04 01; 104(2):765-834. view on PubMed
Lu P, Zhang D, Ding F, Ma J, Xiang YK, Zhao M. Silencing of circCacna1c Inhibits ISO-Induced Cardiac Hypertrophy through miR-29b-2-5p/NFATc1 Axis. Cells. 2023 06 19; 12(12). view on PubMed
Mayrhofer F, Hanson AM, Navedo MF, Xiang YK, Soulika AM, Deng W, Chechneva OV. Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain. J Exp Med. 2023 07 03; 220(7). view on PubMed
Martinez JM, Shen A, Xu B, Jovanovic A, de Chabot J, Zhang J, Xiang YK. Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Sci Signal. 2023 03 28; 16(778):eade3380. view on PubMed
Han Y, Dawson JRD, DeMarco KR, Rouen KC, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Vorobyov I. Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein. Proc Natl Acad Sci U S A. 2023 03 07; 120(10):e2215916120. view on PubMed
Jovanovic A, Xu B, Zhu C, Ren D, Wang H, Krause-Hauch M, Abel ED, Li J, Xiang YK. Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart. JACC Basic Transl Sci. 2023 Jun; 8(6):638-655. view on PubMed
Caldwell JL, Lee IJ, Ngo L, Wang L, Bahriz S, Xu B, Bers DM, Navedo MF, Bossuyt J, Xiang YK, Ripplinger CM. Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics. Sci Adv. 2023 01 20; 9(3):eadd5799. view on PubMed
Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK. Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling. Circ Res. 2023 01 06; 132(1):106-108. view on PubMed
Ren L, Thai PN, Gopireddy RR, Timofeyev V, Ledford HA, Woltz RL, Park S, Puglisi JL, Moreno CM, Santana LF, Conti AC, Kotlikoff MI, Xiang YK, Yarov-Yarovoy V, Zaccolo M, Zhang XD, Yamoah EN, Navedo MF, Chiamvimonvat N. Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight. 2022 11 22; 7(22). view on PubMed
Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK. Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes. Cell Commun Signal. 2022 09 14; 20(1):143. view on PubMed
Ren L, Gopireddy RR, Perkins G, Zhang H, Timofeyev V, Lyu Y, Diloretto DA, Trinh P, Sirish P, Overton JL, Xu W, Grainger N, Xiang YK, Dedkova EN, Zhang XD, Yamoah EN, Navedo MF, Thai PN, Chiamvimonvat N. Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2206708119. view on PubMed
Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022 07 17; 117(1):37. view on PubMed
Shannon TR, Bare DJ, Van Dijk S, Raofi S, Huynh TN, Xiang YK, Bossuyt J, Dodge-Kafka KL, Ginsburg KS, Bers DM. Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7. Function (Oxf). 2022; 3(3):zqac020. view on PubMed
Lu P, Ding F, Xiang YK, Hao L, Zhao M. Noncoding RNAs in Cardiac Hypertrophy and Heart Failure. Cells. 2022 02 23; 11(5). view on PubMed
Guo P, Tai Y, Wang M, Sun H, Zhang L, Wei W, Xiang YK, Wang Q. Gα12 and Gα13: Versatility in Physiology and Pathology. Front Cell Dev Biol. 2022; 10:809425. view on PubMed
Reddy GR, Ren L, Thai PN, Caldwell JL, Zaccolo M, Bossuyt J, Ripplinger CM, Xiang YK, Nieves-Cintrón M, Chiamvimonvat N, Navedo MF. Deciphering cellular signals in adult mouse sinoatrial node cells. iScience. 2022 Jan 21; 25(1):103693. view on PubMed
Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circ Res. 2021 10 29; 129(10):965-967. view on PubMed
Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility. Cardiovasc Res. 2021 08 29; 117(10):2237-2251. view on PubMed
Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 01 22; 128(2):246-261. view on PubMed
Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 10 20; 11(1):5303. view on PubMed
Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. view on PubMed
Sun X, Han F, Lu Q, Li X, Ren D, Zhang J, Han Y, Xiang YK, Li J. Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet-Induced Obese Mice. Diabetes. 2020 06; 69(6):1292-1305. view on PubMed
Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6). view on PubMed
Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. Hyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 03; 34(3):3996-4008. view on PubMed
Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. Elife. 2019 10 14; 8. view on PubMed
Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Elife. 2019 08 06; 8. view on PubMed
West TM, Wang Q, Deng B, Zhang Y, Barbagallo F, Reddy GR, Chen D, Phan KS, Xu B, Isidori A, Xiang YK. Phosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts. J Am Heart Assoc. 2019 08 06; 8(15):e012273. view on PubMed
Bers DM, Xiang YK, Zaccolo M. Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters. Physiology (Bethesda). 2019 07 01; 34(4):240-249. view on PubMed
Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. view on PubMed
Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. J Physiol. 2019 04; 597(8):2139-2162. view on PubMed
Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. view on PubMed
Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. view on PubMed
Zhou Y, Chen L, Zhou X, Pei Y, Wei S, Mehmood A, Xiang YK, Wang D. Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene. J Appl Bioinforma Comput Biol. 2018; 7(3). view on PubMed
Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 09 06; 174(6):1436-1449.e20. view on PubMed
Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM, Xiang YK, Yasuda R, Chen B, Shen K. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Dev Cell. 2018 05 07; 45(3):362-375.e3. view on PubMed
Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 2018 04 26; 61(8):3541-3550. view on PubMed
Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. view on PubMed
Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L. Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Sci Rep. 2018 02 23; 8(1):3556. view on PubMed
Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. view on PubMed
Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF. β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes. Sci Rep. 2017 08 11; 7(1):7890. view on PubMed
Fu Q, Shi Q, West TM, Xiang YK. Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors. J Cardiovasc Pharmacol. 2017 Aug; 70(2):74-86. view on PubMed
Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes. Cardiovasc Res. 2017 May 01; 113(6):656-670. view on PubMed
Pofi R, Fiore D, De Gaetano R, Panio G, Gianfrilli D, Pozza C, Barbagallo F, Xiang YK, Giannakakis K, Morano S, Lenzi A, Naro F, Isidori AM, Venneri MA. Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7. Sci Rep. 2017 03 15; 7:44584. view on PubMed
Fu Q, Wang Q, Xiang YK. Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab. 2017 06; 28(6):416-427. view on PubMed
Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017 03 15; 595(6):1973-1986. view on PubMed
Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. view on PubMed
Zou W, Shen A, Dong X, Tugizova M, Xiang YK, Shen K. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Elife. 2016 10 05; 5. view on PubMed
Chen X, O'Connell TD, Xiang YK. With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. Circ Res. 2016 09 30; 119(8):888-90. view on PubMed
Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. view on PubMed
Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K. Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins. Cell Signal. 2016 08; 28(8):1001-14. view on PubMed
Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. view on PubMed
Zhao H, Shen A, Xiang YK, Corey DP. Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity. PLoS One. 2016; 11(3):e0150125. view on PubMed
Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. view on PubMed
Fu Q, Xiang YK. Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor Signaling. Prog Mol Biol Transl Sci. 2015; 132:151-88. view on PubMed
Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F. Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes. Cardiovasc Res. 2015 Jun 01; 106(3):408-20. view on PubMed
Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes. Cell Signal. 2015 Mar; 27(3):707-15. view on PubMed
Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK. A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem. 2014 May 23; 289(21):14771-81. view on PubMed
Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89. view on PubMed
Wisely EV, Xiang YK, Oddo S. Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Hum Mol Genet. 2014 Aug 01; 23(15):4024-34. view on PubMed
Clancy CE, Xiang YK. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. view on PubMed
Kim YA, Kim MY, Yu HY, Mishra SK, Lee JH, Choi KS, Kim JH, Xiang YK, Jung YS. Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury. J Mol Med (Berl). 2013 Nov; 91(11):1303-13. view on PubMed
Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW. SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains. PLoS One. 2013; 8(5):e63379. view on PubMed
Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW. Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling. J Biol Chem. 2013 Jun 14; 288(24):17918-31. view on PubMed
Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct; 23(7):250-6. view on PubMed
Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12; 288(15):10298-307. view on PubMed
Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26. view on PubMed
Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK. Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. PLoS One. 2012; 7(8):e42658. view on PubMed
Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6578-83. view on PubMed
Jain A, Liu R, Xiang YK, Ha T. Single-molecule pull-down for studying protein interactions. Nat Protoc. 2012 Feb 09; 7(3):445-52. view on PubMed
Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J. Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia. Adv Exp Med Biol. 2012; 758:287-94. view on PubMed
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Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. J Biol Chem. 2011 Sep 09; 286(36):31852-63. view on PubMed
Xiang YK. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res. 2011 Jul 08; 109(2):231-44. view on PubMed
Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T. Probing cellular protein complexes using single-molecule pull-down. Nature. 2011 May 26; 473(7348):484-8. view on PubMed
Wang D, Xiang YK. β-adrenergic receptor, amyloid β-peptide, and Alzheimer's disease. Curr Top Membr. 2011; 67:205-28. view on PubMed
Liu S, Zhang J, Xiang YK. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes. Biochem Biophys Res Commun. 2011 Jan 14; 404(2):581-6. view on PubMed
De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK. Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol. 2010 Sep; 78(3):340-9. view on PubMed
Yum K, Yu MF, Wang N, Xiang YK. Biofunctionalized nanoneedles for the direct and site-selective delivery of probes into living cells. Biochim Biophys Acta. 2011 Mar; 1810(3):330-8. view on PubMed
Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, Xiang YK. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J. 2010 Sep; 24(9):3511-21. view on PubMed
