Rhonda Voskuhl*
Dr. Rhonda R. Voskuhl holds the Jack H. Skirball Chair for Multiple Sclerosis Research.
Publications:
Voskuhl R. All women with MS should start hormone replacement therapy at menopause unless contraindicated: Yes. Mult Scler. 2024 Jun 22; 13524585241255002. view on PubMed
Itoh N, Itoh Y, Stiles L, Voskuhl R. Sex differences in the neuronal transcriptome and synaptic mitochondrial function in the cerebral cortex of a multiple sclerosis model. Front Neurol. 2023; 14:1268411. view on PubMed
Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nat Commun. 2023 09 28; 14(1):6044. view on PubMed
Meyer CE, Smith AW, Padilla-Requerey AA, Farkhondeh V, Itoh N, Itoh Y, Gao JL, Herbig PD, Nguyen Q, Ngo KH, Oberoi MR, Siddarth P, Voskuhl RR, MacKenzie-Graham A. Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol. Lab Invest. 2023 08; 103(8):100189. view on PubMed
Voskuhl R, Itoh Y. The X factor in neurodegeneration. J Exp Med. 2022 12 05; 219(12). view on PubMed
Voskuhl RR, MacKenzie-Graham A. Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis. Front Mol Neurosci. 2022; 15:1024058. view on PubMed
Voskuhl R, Kuhle J, Siddarth P, Itoh N, Patel K, MacKenzie-Graham A. Decreased neurofilament light chain levels in estriol-treated multiple sclerosis. Ann Clin Transl Neurol. 2022 08; 9(8):1316-1320. view on PubMed
Killestein J, Schoonheim MM, Voskuhl RR. B-Cell Depletion and COVID-19 Severity in Multiple Sclerosis: Remaining Challenges. Neurology. 2021 11 09; 97(19):885-886. view on PubMed
Voskuhl R. A new cell subtype that confers neuroprotection. Nat Immunol. 2020 12; 21(12):1477-1478. view on PubMed
Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, Cooper G, Asseyer S, Chien C, Brandt AU, Meyer CE, MacKenzie-Graham A. Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ. 2020 08 28; 11(1):49. view on PubMed
Krysko KM, Graves JS, Dobson R, Altintas A, Amato MP, Bernard J, Bonavita S, Bove R, Cavalla P, Clerico M, Corona T, Doshi A, Fragoso Y, Jacobs D, Jokubaitis V, Landi D, Llamosa G, Longbrake EE, Maillart E, Marta M, Midaglia L, Shah S, Tintore M, van der Walt A, Voskuhl R, Wang Y, Zabad RK, Zeydan B, Houtchens M, Hellwig K. Sex effects across the lifespan in women with multiple sclerosis. Ther Adv Neurol Disord. 2020; 13:1756286420936166. view on PubMed
Voskuhl RR. The effect of sex on multiple sclerosis risk and disease progression. Mult Scler. 2020 04; 26(5):554-560. view on PubMed
Golden LC, Itoh Y, Itoh N, Iyengar S, Coit P, Salama Y, Arnold AP, Sawalha AH, Voskuhl RR. Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26779-26787. view on PubMed
Itoh Y, Golden LC, Itoh N, Matsukawa MA, Ren E, Tse V, Arnold AP, Voskuhl RR. The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity. J Clin Invest. 2019 08 12; 129(9):3852-3863. view on PubMed
Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR. The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression. Sci Rep. 2019 07 10; 9(1):10010. view on PubMed
Voskuhl RR, Itoh N, Tassoni A, Matsukawa MA, Ren E, Tse V, Jang E, Suen TT, Itoh Y. Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10130-10139. view on PubMed
Voskuhl R, Klein S. Sex is a biological variable - in the brain too. Nature. 2019 04; 568(7751):171. view on PubMed
Meyer CE, Gao JL, Cheng JY, Oberoi MR, Johnsonbaugh H, Lepore S, Kurth F, Thurston MJ, Itoh N, Patel KR, Voskuhl RR, MacKenzie-Graham A. Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis. Mult Scler. 2020 03; 26(3):294-303. view on PubMed
Kammel LG, Wei W, Jami SA, Voskuhl RR, O'Dell TJ. Enhanced GABAergic Tonic Inhibition Reduces Intrinsic Excitability of Hippocampal CA1 Pyramidal Cells in Experimental Autoimmune Encephalomyelitis. Neuroscience. 2018 12 15; 395:89-100. view on PubMed
MacKenzie-Graham A, Brook J, Kurth F, Itoh Y, Meyer C, Montag MJ, Wang HJ, Elashoff R, Voskuhl RR. Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry. Brain Behav. 2018 09; 8(9):e01086. view on PubMed
Voskuhl R. It is time to conduct phase 3 clinical trials of sex hormones in MS - Yes. Mult Scler. 2018 10; 24(11):1413-1415. view on PubMed
Kim RY, Mangu D, Hoffman AS, Kavosh R, Jung E, Itoh N, Voskuhl R. Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis. Brain. 2018 01 01; 141(1):132-147. view on PubMed
Voskuhl RR, Sawalha AH, Itoh Y. Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression. Mult Scler. 2018 01; 24(1):22-31. view on PubMed
Itoh N, Itoh Y, Tassoni A, Ren E, Kaito M, Ohno A, Ao Y, Farkhondeh V, Johnsonbaugh H, Burda J, Sofroniew MV, Voskuhl RR. Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E302-E309. view on PubMed
Voskuhl R, Momtazee C. Pregnancy: Effect on Multiple Sclerosis, Treatment Considerations, and Breastfeeding. Neurotherapeutics. 2017 Oct; 14(4):974-984. view on PubMed
Itoh Y, Voskuhl RR. Cell specificity dictates similarities in gene expression in multiple sclerosis, Parkinson's disease, and Alzheimer's disease. PLoS One. 2017; 12(7):e0181349. view on PubMed
Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH. Speaking out about gender imbalance in invited speakers improves diversity. Nat Immunol. 2017 04 18; 18(5):475-478. view on PubMed
Golden LC, Voskuhl R. The importance of studying sex differences in disease: The example of multiple sclerosis. J Neurosci Res. 2017 01 02; 95(1-2):633-643. view on PubMed
Itoh N, Kim R, Peng M, DiFilippo E, Johnsonbaugh H, MacKenzie-Graham A, Voskuhl RR. Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis. J Neuroimmunol. 2017 03 15; 304:63-71. view on PubMed
Voskuhl R, Patti F. Hormone replacement in menopausal women with multiple sclerosis: Looking back, thinking forward. Neurology. 2016 10 04; 87(14):1430-1431. view on PubMed
Gold SM, Voskuhl RR. Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application. Semin Immunopathol. 2016 11; 38(6):709-718. view on PubMed
MacKenzie-Graham A, Kurth F, Itoh Y, Wang HJ, Montag MJ, Elashoff R, Voskuhl RR. Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis. JAMA Neurol. 2016 Aug 01; 73(8):944-53. view on PubMed
Voskuhl R. Rebound Relapses After Ceasing Another Disease-Modifying Treatment in Patients With Multiple Sclerosis: Are There Lessons to Be Learned? JAMA Neurol. 2016 07 01; 73(7):775-6. view on PubMed
Voskuhl R, Wang H, Elashoff RM. Why use sex hormones in relapsing-remitting multiple sclerosis? - Authors' reply. Lancet Neurol. 2016 07; 15(8):790-791. view on PubMed
Voskuhl R. Preclinical studies of sex differences: a clinical perspective. Biol Sex Differ. 2016; 7:7. view on PubMed
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R. Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Jan; 15(1):35-46. view on PubMed
Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR. Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Sep 15; 274(1-2):53-61. view on PubMed
Kurth F, Luders E, Sicotte NL, Gaser C, Giesser BS, Swerdloff RS, Montag MJ, Voskuhl RR, Mackenzie-Graham A. Neuroprotective effects of testosterone treatment in men with multiple sclerosis. Neuroimage Clin. 2014; 4:454-60. view on PubMed
Du S, Itoh N, Askarinam S, Hill H, Arnold AP, Voskuhl RR. XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2806-11. view on PubMed
Ghandour S, Voskuhl R, Schumacher M. The androgen receptor as a therapeutic target for myelin repair in demyelinating diseases. Expert Rev Endocrinol Metab. 2014 Jan; 9(1):5-7. view on PubMed
Spence RD, Wisdom AJ, Cao Y, Hill HM, Mongerson CR, Stapornkul B, Itoh N, Sofroniew MV, Voskuhl RR. Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. J Neurosci. 2013 Jun 26; 33(26):10924-33. view on PubMed
Wisdom AJ, Cao Y, Itoh N, Spence RD, Voskuhl RR. Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model. J Neurosci Res. 2013 Jul; 91(7):901-8. view on PubMed
Voskuhl RR. Assisted reproduction technology in multiple sclerosis: giving birth to a new avenue of research in hormones and autoimmunity. Ann Neurol. 2012 Nov; 72(5):631-2. view on PubMed
Ziehn MO, Avedisian AA, Dervin SM, Umeda EA, O'Dell TJ, Voskuhl RR. Therapeutic testosterone administration preserves excitatory synaptic transmission in the hippocampus during autoimmune demyelinating disease. J Neurosci. 2012 Sep 05; 32(36):12312-24. view on PubMed
Gold SM, Sasidhar MV, Lagishetty V, Spence RD, Umeda E, Ziehn MO, Krieger T, Schulz KH, Heesen C, Hewison M, Voskuhl RR. Dynamic development of glucocorticoid resistance during autoimmune neuroinflammation. J Clin Endocrinol Metab. 2012 Aug; 97(8):E1402-10. view on PubMed
Sasidhar MV, Itoh N, Gold SM, Lawson GW, Voskuhl RR. The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. Ann Rheum Dis. 2012 Aug; 71(8):1418-22. view on PubMed
Ziehn MO, Avedisian AA, Dervin SM, O'Dell TJ, Voskuhl RR. Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease. Lab Invest. 2012 Aug; 92(8):1234-45. view on PubMed
Voskuhl RR, Gold SM. Sex-related factors in multiple sclerosis susceptibility and progression. Nat Rev Neurol. 2012 Mar 27; 8(5):255-63. view on PubMed
MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs RE, Toga AW, Voskuhl RR. Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. J Neurosci Res. 2012 Jul; 90(7):1310-23. view on PubMed
Daumer M, Weinshenker BG, Voskuhl R. Pregnancy: a "modifiable" risk factor in MS? Neurology. 2012 Mar 20; 78(12):846-8. view on PubMed
Spence RD, Voskuhl RR. Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Front Neuroendocrinol. 2012 Jan; 33(1):105-15. view on PubMed
MacKenzie-Graham A, Rinek GA, Avedisian A, Gold SM, Frew AJ, Aguilar C, Lin DR, Umeda E, Voskuhl RR, Alger JR. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. Neuroimage. 2012 Mar; 60(1):95-104. view on PubMed
Spence RD, Hamby ME, Umeda E, Itoh N, Du S, Wisdom AJ, Cao Y, Bondar G, Lam J, Ao Y, Sandoval F, Suriany S, Sofroniew MV, Voskuhl RR. Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8867-72. view on PubMed
Voskuhl R. Sex differences in autoimmune diseases. Biol Sex Differ. 2011 Jan 04; 2(1):1. view on PubMed
Du S, Sandoval F, Trinh P, Umeda E, Voskuhl R. Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. Eur J Immunol. 2011 Jan; 41(1):140-50. view on PubMed
Mangiardi M, Crawford DK, Xia X, Du S, Simon-Freeman R, Voskuhl RR, Tiwari-Woodruff SK. An animal model of cortical and callosal pathology in multiple sclerosis. Brain Pathol. 2011 May; 21(3):263-78. view on PubMed
Crawford DK, Mangiardi M, Song B, Patel R, Du S, Sofroniew MV, Voskuhl RR, Tiwari-Woodruff SK. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010 Oct; 133(10):2999-3016. view on PubMed
Ziehn MO, Avedisian AA, Tiwari-Woodruff S, Voskuhl RR. Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Lab Invest. 2010 May; 90(5):774-86. view on PubMed
Du S, Sandoval F, Trinh P, Voskuhl RR. Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010 Feb 26; 219(1-2):64-74. view on PubMed
Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari-Woodruff S, Sofroniew MV. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci. 2009 Sep 16; 29(37):11511-22. view on PubMed
Gold SM, Sasidhar MV, Morales LB, Du S, Sicotte NL, Tiwari-Woodruff SK, Voskuhl RR. Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). Lab Invest. 2009 Oct; 89(10):1076-83. view on PubMed
MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR. Purkinje cell loss in experimental autoimmune encephalomyelitis. Neuroimage. 2009 Dec; 48(4):637-51. view on PubMed
Gold SM, Voskuhl RR. Estrogen treatment in multiple sclerosis. J Neurol Sci. 2009 Nov 15; 286(1-2):99-103. view on PubMed
Tiwari-Woodruff S, Voskuhl RR. Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice. J Neurol Sci. 2009 Nov 15; 286(1-2):81-5. view on PubMed
Gold SM, Voskuhl RR. Estrogen and testosterone therapies in multiple sclerosis. Prog Brain Res. 2009; 175:239-51. view on PubMed
Voskuhl R, Wu TC. Do estroprogestinic hormones protect against chemotherapy-induced amenorrhea in multiple sclerosis? Nat Clin Pract Neurol. 2009 Jan; 5(1):18-9. view on PubMed
Gold SM, Chalifoux S, Giesser BS, Voskuhl RR. Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone. J Neuroinflammation. 2008 Jul 31; 5:32. view on PubMed
Wu J, Ohlsson M, Warner EA, Loo KK, Hoang TX, Voskuhl RR, Havton LA. Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis. Neuroscience. 2008 Oct 15; 156(3):586-96. view on PubMed
Smith-Bouvier DL, Divekar AA, Sasidhar M, Du S, Tiwari-Woodruff SK, King JK, Arnold AP, Singh RR, Voskuhl RR. A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med. 2008 May 12; 205(5):1099-108. view on PubMed
Tiwari-Woodruff S, Morales LB, Lee R, Voskuhl RR. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14813-8. view on PubMed
Sicotte NL, Giesser BS, Tandon V, Klutch R, Steiner B, Drain AE, Shattuck DW, Hull L, Wang HJ, Elashoff RM, Swerdloff RS, Voskuhl RR. Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol. 2007 May; 64(5):683-8. view on PubMed
Smith DL, Dong X, Du S, Oh M, Singh RR, Voskuhl RR. A female preponderance for chemically induced lupus in SJL/J mice. Clin Immunol. 2007 Jan; 122(1):101-7. view on PubMed
Gold SM, Voskuhl RR. Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders. Curr Opin Investig Drugs. 2006 Jul; 7(7):625-30. view on PubMed
MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006 Sep; 32(3):1016-23. view on PubMed
Morales LB, Loo KK, Liu HB, Peterson C, Tiwari-Woodruff S, Voskuhl RR. Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. J Neurosci. 2006 Jun 21; 26(25):6823-33. view on PubMed
Palaszynski KM, Smith DL, Kamrava S, Burgoyne PS, Arnold AP, Voskuhl RR. A yin-yang effect between sex chromosome complement and sex hormones on the immune response. Endocrinology. 2005 Aug; 146(8):3280-5. view on PubMed
Liu H, Ding Y, Voskuhl RR. Method to detect functional estrogen receptor expression using estrogen receptor probing compound. J Immunoassay Immunochem. 2005; 26(4):295-301. view on PubMed
Palaszynski KM, Liu H, Loo KK, Voskuhl RR. Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol. 2004 Apr; 149(1-2):84-9. view on PubMed
Palaszynski KM, Loo KK, Ashouri JF, Liu HB, Voskuhl RR. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol. 2004 Jan; 146(1-2):144-52. view on PubMed
Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR. Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosis. J Neuroimmunol. 2004 Jan; 146(1-2):209-15. view on PubMed
Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB, Voskuhl RR. Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. J Immunol. 2003 Dec 15; 171(12):6936-40. view on PubMed
Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR. Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 01; 171(11):6267-74. view on PubMed
Sicotte NL, Voskuhl RR, Bouvier S, Klutch R, Cohen MS, Mazziotta JC. Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla. Invest Radiol. 2003 Jul; 38(7):423-7. view on PubMed
Voskuhl RR, Pribyl TM, Kampf K, Handley V, Liu HB, Feng J, Campagnoni CW, Soldan SS, Messing A, Campagnoni AT. Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice. J Neuroimmunol. 2003 Jun; 139(1-2):44-50. view on PubMed
Voskuhl RR. Hormone-based therapies in MS. Int MS J. 2003 Jun; 10(2):60-6. view on PubMed
Sicotte NL, Liva SM, Klutch R, Pfeiffer P, Bouvier S, Odesa S, Wu TC, Voskuhl RR. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann Neurol. 2002 Oct; 52(4):421-8. view on PubMed
Voskuhl RR. Gender issues and multiple sclerosis. Curr Neurol Neurosci Rep. 2002 May; 2(3):277-86. view on PubMed
Sicotte NL, Voskuhl RR. Onset of multiple sclerosis associated with anti-TNF therapy. Neurology. 2001 Nov 27; 57(10):1885-8. view on PubMed
Voskuhl RR, Palaszynski K. Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neuroscientist. 2001 Jun; 7(3):258-70. view on PubMed
Liu H, MacKenzie-Graham AJ, Palaszynski K, Liva S, Voskuhl RR. "Classic" myelin basic proteins are expressed in lymphoid tissue macrophages. J Neuroimmunol. 2001 May 01; 116(1):83-93. view on PubMed
Liu H, MacKenzie-Graham AJ, Kim S, Voskuhl RR. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J Neuroimmunol. 2001 Apr 02; 115(1-2):118-26. view on PubMed
Kim S, Voskuhl RR. Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis. J Immunol. 1999 May 01; 162(9):5561-8. view on PubMed
Kim S, Liva SM, Dalal MA, Verity MA, Voskuhl RR. Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis. Neurology. 1999 Apr 12; 52(6):1230-8. view on PubMed
Kahn MA, Dopp JM, Liva S, MacKenzie-Graham AJ, Chang R, Huang A, Nazarian R, Dell'Albani P, Condorelli D, Voskuhl RR, de Vellis J. Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis. J Neuroimmunol. 1999 Mar 01; 95(1-2):19-34. view on PubMed
Voskuhl RR. Myelin protein expression in lymphoid tissues: implications for peripheral tolerance. Immunol Rev. 1998 Aug; 164:81-92. view on PubMed
Ding M, Zhang M, Wong JL, Rogers NE, Ignarro LJ, Voskuhl RR. Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol. 1998 Mar 15; 160(6):2560-4. view on PubMed
MacKenzie-Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR. Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis. J Immunol. 1997 Nov 01; 159(9):4602-10. view on PubMed
Ding M, Wong JL, Rogers NE, Ignarro LJ, Voskuhl RR. Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis. J Neuroimmunol. 1997 Jul; 77(1):99-106. view on PubMed
Dalal M, Kim S, Voskuhl RR. Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response. J Immunol. 1997 Jul 01; 159(1):3-6. view on PubMed
Capello E, Voskuhl RR, McFarland HF, Raine CS. Multiple sclerosis: re-expression of a developmental gene in chronic lesions correlates with remyelination. Ann Neurol. 1997 Jun; 41(6):797-805. view on PubMed
Nagasato K, Farris RW, Dubois-Dalcq M, Voskuhl RR. Exon 2 containing myelin basic protein (MBP) transcripts are expressed in lesions of experimental allergic encephalomyelitis (EAE). J Neuroimmunol. 1997 Jan; 72(1):21-5. view on PubMed
Ding M, Zhang M, Wong JL, Voskuhl RR, Ellison GW. Antisense blockade of inducible nitric oxide synthase in glial cells derived from adult SJL mice. Neurosci Lett. 1996 Dec 13; 220(2):89-92. view on PubMed
Voskuhl RR, Farris RW, Nagasato K, McFarland HF, Dalcq MD. Epitope spreading occurs in active but not passive EAE induced by myelin basic protein. J Neuroimmunol. 1996 Nov; 70(2):103-11. view on PubMed
Tranquill LR, Skinner E, Campagnoni C, Vergelli M, Hemmer B, Muraro P, Martin R, McFarland HF, Campagnoni AT, Voskuhl RR. Human T lymphocytes specific for the immunodominant 83-99 epitope of myelin basic protein: recognition of golli MBP HOG 7. J Neurosci Res. 1996 Sep 15; 45(6):820-8. view on PubMed
Pitchekian-Halabi H, Campagnoni CW, Skinner E, Kampf K, Campagnoni AT, Voskuhl RR. Strain-related differences in the ability of T lymphocytes to recognize proteins encoded by the golli-myelin basic protein gene. J Neuroimmunol. 1996 Aug; 68(1-2):121-9. view on PubMed
Voskuhl RR, Goldstein AM, Simonis T, Davey RJ, McFarland HF. DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families. Ann Neurol. 1996 Jun; 39(6):804-7. view on PubMed
Voskuhl RR, Pitchekian-Halabi H, MacKenzie-Graham A, McFarland HF, Raine CS. Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis. Ann Neurol. 1996 Jun; 39(6):724-33. view on PubMed
Richert JR, Robinson ED, Camphausen K, Martin R, Voskuhl RR, Faerber MA, McFarland HF, Hurley CK. Diversity of T-cell receptor V alpha, V beta, and CDR3 expression by myelin basic protein-specific human T-cell clones. Neurology. 1995 Oct; 45(10):1919-22. view on PubMed
Nye SH, Pelfrey CM, Burkwit JJ, Voskuhl RR, Lenardo MJ, Mueller JP. Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein. Mol Immunol. 1995 Oct; 32(14-15):1131-41. view on PubMed
Richert JR, Robinson ED, Camphausen K, Hastings E, Martin R, Voskuhl R, McFarland HF. T-cell receptor alpha and beta CDR3 expression by myelin basic protein-specific human T-cell clones. Ann N Y Acad Sci. 1995 Jul 07; 756:317-8. view on PubMed
Voskuhl RR, Robinson ED, Segal BM, Tranquill L, Camphausen K, Albert PS, Richert JR, McFarland HF. HLA restriction and TCR usage of T lymphocytes specific for a novel candidate autoantigen, X2 MBP, in multiple sclerosis. J Immunol. 1994 Nov 15; 153(10):4834-44. view on PubMed
Segal BM, Raine CS, McFarlin DE, Voskuhl RR, McFarland HF. Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination. J Neuroimmunol. 1994 Apr; 51(1):7-19. view on PubMed
Martin R, Voskuhl R, Flerlage M, McFarlin DE, McFarland HF. Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis. Ann Neurol. 1993 Oct; 34(4):524-35. view on PubMed
Voskuhl RR, McFarlin DE, Tranquill LR, Deibler G, Stone R, Maloni H, McFarland HF. A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination. J Neuroimmunol. 1993 Jul; 46(1-2):137-44. view on PubMed
Voskuhl RR, Martin R, McFarland HF. A functional basis for the association of HLA class II genes and susceptibility to multiple sclerosis: cellular immune responses to myelin basic protein in a multiplex family. J Neuroimmunol. 1993 Feb; 42(2):199-207. view on PubMed
Voskuhl RR, McFarlin DE, Stone R, McFarland HF. T-lymphocyte recognition of a portion of myelin basic protein encoded by an exon expressed during myelination. J Neuroimmunol. 1993 Feb; 42(2):187-91. view on PubMed
Voskuhl RR, Martin R, Bergman C, Dalal M, Ruddle NH, McFarland HF. T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. Autoimmunity. 1993; 15(2):137-43. view on PubMed
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