Nicolas Massaly

Publications:

Ruyle BC, Masud S, Kesaraju R, Tahirkheli M, Modh J, Roth CG, Angulo-Lopera S, Lintz T, Higginbotham JA, Massaly N, Morón JA. Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior. Elife. 2025 Apr 01; 13. view on PubMed

Ruyle BC, Masud S, Kesaraju R, Tahirkheli M, Modh J, Roth CG, Angulo-Lopera S, Lintz T, Higginbotham JA, Massaly N, Moron JA. Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior. bioRxiv. 2025 Jan 15. view on PubMed

Ciatti JL, Vázquez-Guardado A, Brings VE, Park J, Ruyle B, Ober RA, McLuckie AJ, Talcott MR, Carter EA, Burrell AR, Sponenburg RA, Trueb J, Gupta P, Kim J, Avila R, Seong M, Slivicki RA, Kaplan MA, Villalpando-Hernandez B, Massaly N, Montana MC, Pet M, Huang Y, Morón JA, Gereau RW, Rogers JA. An autonomous implantable device for the prevention of death from opioid overdose. Sci Adv. 2024 Oct 25; 10(43):eadr3567. view on PubMed

Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Morón JA, Zamponi GW, Trang T. Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry. Nat Commun. 2024 Jul 24; 15(1):6264. view on PubMed

Ciatti JL, Vazquez-Guardado A, Brings VE, Park J, Ruyle B, Ober RA, McLuckie AJ, Talcott MR, Carter EA, Burrell AR, Sponenburg RA, Trueb J, Gupta P, Kim J, Avila R, Seong M, Slivicki RA, Kaplan MA, Villalpando-Hernandez B, Massaly N, Montana MC, Pet M, Huang Y, Morón JA, Gereau RW, Rogers JA. An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose. bioRxiv. 2024 Jul 02. view on PubMed

Markovic T, Higginbotham J, Ruyle B, Massaly N, Yoon HJ, Kuo CC, Kim JR, Yi J, Garcia JJ, Sze E, Abt J, Teich RH, Dearman JJ, McCall JG, Morón JA. A locus coeruleus to dorsal hippocampus pathway mediates cue-induced reinstatement of opioid self-administration in male and female rats. Neuropsychopharmacology. 2024 May; 49(6):915-923. view on PubMed

Ibrahim KM, Massaly N, Yoon HJ, Sandoval R, Widman AJ, Heuermann RJ, Williams S, Post W, Pathiranage S, Lintz T, Zec A, Park A, Yu W, Kash TL, Gereau RW, Morón JA. Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons. Nat Commun. 2024 Jan 29; 15(1):750. view on PubMed

Tejeda HA, Massaly N, Corder G, Cahill CM. Editorial: Broadening our conceptual understanding of endogenous opioids in systems neuroscience. Front Syst Neurosci. 2023; 17:1212650. view on PubMed

Higginbotham JA, Markovic T, Massaly N, Morón JA. Endogenous opioid systems alterations in pain and opioid use disorder. Front Syst Neurosci. 2022; 16:1014768. view on PubMed

Burek DJ, Massaly N, Yoon HJ, Doering M, Morón JA. Behavioral outcomes of complete Freund adjuvant-induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis. Pain. 2022 05 01; 163(5):809-819. view on PubMed

Markovic T, Pedersen CE, Massaly N, Vachez YM, Ruyle B, Murphy CA, Abiraman K, Shin JH, Garcia JJ, Yoon HJ, Alvarez VA, Bruchas MR, Creed MC, Morón JA. Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior. Nat Neurosci. 2021 11; 24(11):1601-1613. view on PubMed

Burek DJ, Massaly N, Doering M, Zec A, Gaelen J, Morón JA. Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice. Pain. 2021 06 01; 162(6):1705-1721. view on PubMed

Massaly N, Markovic T, Creed M, Al-Hasani R, Cahill CM, Moron JA. Pain, negative affective states and opioid-based analgesics: Safer pain therapies to dampen addiction. Int Rev Neurobiol. 2021; 157:31-68. view on PubMed

Massaly N, Temp J, Machelska H, Stein C. Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of nonevoked ongoing pain. Pain. 2020 12; 161(12):2798-2804. view on PubMed

Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, Devi LA, Majumdar S. Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. J Med Chem. 2020 11 25; 63(22):13618-13637. view on PubMed

Meyer J, Del Vecchio G, Seitz V, Massaly N, Stein C. Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue. Br J Pharmacol. 2019 12; 176(23):4510-4520. view on PubMed

Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW, McCall JG, Al-Hasani R, Bruchas MR, Morón JA. Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System. Neuron. 2019 05 08; 102(3):564-573.e6. view on PubMed

Massaly N, Morón JA. Pain And Opioid Systems, Implications In The Opioid Epidemic. Curr Opin Behav Sci. 2019 Apr; 26:69-74. view on PubMed

Spahn V, Del Vecchio G, Labuz D, Rodriguez-Gaztelumendi A, Massaly N, Temp J, Durmaz V, Sabri P, Reidelbach M, Machelska H, Weber M, Stein C. A nontoxic pain killer designed by modeling of pathological receptor conformations. Science. 2017 03 03; 355(6328):966-969. view on PubMed

Massaly N, Morón JA, Al-Hasani R. A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System. Front Neurosci. 2016; 10:480. view on PubMed

Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA. Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons. Neuropsychopharmacology. 2016 10; 41(11):2668-78. view on PubMed

Massaly N, Francès B, Moulédous L. Roles of the ubiquitin proteasome system in the effects of drugs of abuse. Front Mol Neurosci. 2014; 7:99. view on PubMed

Massaly N, Dahan L, Baudonnat M, Hovnanian C, Rekik K, Solinas M, David V, Pech S, Zajac JM, Roullet P, Mouledous L, Frances B. Involvement of protein degradation by the ubiquitin proteasome system in opiate addictive behaviors. Neuropsychopharmacology. 2013 Mar; 38(4):596-604. view on PubMed

Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. Antioxid Redox Signal. 2011 Sep 15; 15(6):1477-96. view on PubMed

Duparc T, Naslain D, Colom A, Muccioli GG, Massaly N, Delzenne NM, Valet P, Cani PD, Knauf C. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus. Antioxid Redox Signal. 2011 Feb 01; 14(3):415-23. view on PubMed