Joseph Crompton

/in /by


Joseph Crompton, M.D., Ph.D.

Office Address:
CHS 54-140

Affiliations

Assistant Professor, Surgery

Research Interests

The UCLA Crompton Lab engages in laboratory and clinical investigations to elucidate mechanisms of immunological memory with the aim of developing novel immunotherapies for cancer patients. In particular, we study:

  • the induction and composition of intra-tumoral tertiary lymphoid structures, with a current focus on the role of B cells in antigen presentation and generation of a neoantigen specific humoral response.
  • the ontogeny of activated CD8 T cells with the aim of elucidating key epigenetic, signal transduction, and metabolic features critical for the development of long-lived memory T cells; previously finding that inhibition of the serine/threonine kinase Akt results in the formation of long-lived T cells with potent anti-tumor activity.
Publications

A selected list of publications:

 

Hotta M, Mona CE, Crompton JG, Armstrong WR, Gafita A, Nelson SD, Eilber FC, Dawson DW, Calais J, Benz MR. FAPI PET Signal in Hibernoma Reflects FAP Expression in Tumor Vasculature Cells. Clin Nucl Med. 2023 Jul. PMID: 37146173 

Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Enrique-Gonzalez A, Swearingen S, Tavanaie N, Dry S, Singh A, Chmielowski B, Crompton JG, Kalbasi A, Eilber FC, Hornicek F, Bernthal N, Nelson SD, Boutros PC, Federman N, Yanagawa J, Soragni A. The landscape of drug sensitivity and resistance in sarcoma. bioRxiv. 2023 May Preprint.PMID: 37292676 

Eckardt MA, Graham DS, Klingbeil KD, Lofftus SY, McCaw TR, Bailey MJ, Goldring CJ, Kendal JK, Kadera BE, Nelson SD, Dry SD, Kalbasi A, Singh AS, Chmielowski B, Eilber FR, Eilber FC, Crompton, JG. Lifelong Imaging Surveillance is Indicated for Patients with Primary Retroperitoneal Liposarcoma. Ann Surg Oncology. 2023. PMID 36581724. 

Sapna P Patel, Megan Othus, Yuanbin Chen , G Paul Wright Jr , Kathleen J Yost , John R Hyngstrom , Siwen Hu-Lieskovan , Christopher D Lao, Leslie A Fecher , Thach-Giao Truong , Jennifer L Eisenstein, Sunandana Chandra Jeffrey A Sosman, Kari L Kendra , Richard C Wu , Craig E Devoe , Gary B Deutsch , Aparna Hegde , Maya Khalil , Ankit Mangla , Amy M Reese , Merrick I Ross, Andrew S Poklepovic, Giao Q Phan, Adedayo A Onitilo, Demet G Yasar , Benjamin C Powers , Gary C Doolittle , Gino K In , Niels Kokot , Geoffrey T Gibney , Michael B Atkins , Montaser Shaheen , James A Warneke , Alexandra Ikeguchi , Jose E Najera , Bartosz Chmielowski , Joseph G 

Crompton , Justin D Floyd , Eddy Hsueh , Kim A Margolin, Warren A Chow , Kenneth F Grossmann, Eliana Dietrich, Victor G Prieto, Michael C Lowe, Elizabeth I Buchbinder , John M Kirkwood, Larissa Korde , James Moon, Elad Sharon, Vernon K Sondak , Antoni Ribas .Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma. New Engl J Med. 2023. PMID 36856617. 

Crompton, JG, Armstrong, WR, Czerzin J, Eilber FC, Benz MR. F-FLT PET/CT as a prognostic imaging biomarker of disease specific survival in patients with soft tissue sarcoma. Journal of Nuclear Medicine. 2021. 

Hotta M, Benz MR, Allen-Auerbach MS, Crompton, JG, Roth MD, Eilber FC, Calais J. High Ga-FAPI-46 uptake in a pulmonary necrotizing granuloma in a patient with subcutaneous lipoma. Euro J Nucl Med Mol Imaging. 2022. PMID 34546387. 

Benz MR, Crompton, JG, Harder D. PET/CT variants and pitfalls in bone and soft tissue sarcoma. Semin Nucle Med. 2021. 

Crompton, JG, Busam KJ, Bartlett EK. Interpretation of the Complex Melanoma Pathology Report. Surg Onc Clin N Amer. 2020. 

Osorio JC, Abrour KC, Le DT, Durham JN, Plodkowski AJ, Halpenny DF, Ginsberg MS, Sawan P, Crompton JG et al. Lesion-level response dynamics to programmed cell death protein (PD-1) blockade. J Clin Oncol. 2019. 

Crompton JG, Crompton PD, Matzinger P. Does atelectasis cause fever after surgery? Putting a damper on dogma. JAMA Surg. 2019.