Hong Zhou*

Dr. Zhou is a professor in the Department of Microbiology, Immunology and Molecular Genetics and the founding director of the UCLA Electron Imaging Center for Nanomachines.

Websites:

The EICN facility established by Prof. Zhou

Publications:

Stevens A, Cui Y, Shivakoti S, Zhou ZH. Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation. Protein Cell. 2023 06 28; 14(7):544-548. view on PubMed

Ito F, Alvarez-Cabrera AL, Liu S, Yang H, Shiriaeva A, Zhou ZH, Chen XS. Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Sci Adv. 2023 01 04; 9(1):eade3168. view on PubMed

Hu JJ, Lee JKJ, Liu YT, Yu C, Huang L, Aphasizheva I, Aphasizhev R, Zhou ZH. Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase. Structure. 2023 01 05; 31(1):100-110.e4. view on PubMed

Zhekova HR, Jiang J, Wang W, Tsirulnikov K, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Tieleman DP, Hong Zhou Z, Pushkin A, Kurtz I. CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations. Commun Biol. 2022 12 14; 5(1):1372. view on PubMed

Liu S, Xia X, Zhen J, Li Z, Zhou ZH. Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney. Cell Discov. 2022 Nov 22; 8(1):126. view on PubMed

Xia X, Zhou ZH. Using cryoEM and cryoET to visualize membrane penetration of a non-enveloped virus. STAR Protoc. 2022 12 16; 3(4):101825. view on PubMed

Liu YT, Zhang H, Wang H, Tao CL, Bi GQ, Zhou ZH. Isotropic reconstruction for electron tomography with deep learning. Nat Commun. 2022 10 29; 13(1):6482. view on PubMed

Zhou K, Si Z, Ge P, Tsao J, Luo M, Zhou ZH. Atomic model of vesicular stomatitis virus and mechanism of assembly. Nat Commun. 2022 10 10; 13(1):5980. view on PubMed

Liu X, Clemens DL, Lee BY, Yang X, Zhou ZH, Horwitz MA. Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System. mBio. 2022 10 26; 13(5):e0127722. view on PubMed

Zhou ZH. New cryoEM Methods for Studying Native Biological Complexes, in situ and in Action. Microsc Microanal. 2022 Aug; 28(Suppl 1):1246-1247. view on PubMed

He Y, Song H, Chan H, Liu B, Wang Y, Sušac L, Zhou ZH, Feigon J. Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. Nature. 2022 08; 608(7924):813-818. view on PubMed

Xia X, Liu S, Zhou ZH. Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane. Nat Struct Mol Biol. 2022 07; 29(7):698-705. view on PubMed

Si Z, Zhou K, Tsao J, Luo M, Zhou ZH. Locations and in situ structure of the polymerase complex inside the virion of vesicular stomatitis virus. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2111948119. view on PubMed

Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J. Structure of active human telomerase with telomere shelterin protein TPP1. Nature. 2022 04; 604(7906):578-583. view on PubMed

Yang Y, Liu S, Egloff S, Eichhorn CD, Hadjian T, Zhen J, Kiss T, Zhou ZH, Feigon J. Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol Cell. 2022 05 05; 82(9):1724-1736.e7. view on PubMed

Zhang Y, Cui Y, Sun J, Zhou ZH. Multiple conformations of trimeric spikes visualized on a non-enveloped virus. Nat Commun. 2022 01 27; 13(1):550. view on PubMed

Sharma A, Zhang X, Dejnirattisai W, Dai X, Gong D, Wongwiwat W, Duquerroy S, Rouvinski A, Vaney MC, Guardado-Calvo P, Haouz A, England P, Sun R, Zhou ZH, Mongkolsapaya J, Screaton GR, Rey FA. The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell. 2021 12 09; 184(25):6052-6066.e18. view on PubMed

Xia X, Wu W, Cui Y, Roy P, Zhou ZH. Bluetongue virus capsid protein VP5 perforates membranes at low endosomal pH during viral entry. Nat Microbiol. 2021 11; 6(11):1424-1432. view on PubMed

Wang W, Tsirulnikov K, Zhekova HR, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Zhou ZH, Pushkin A, Kurtz I. Publisher Correction: Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE. Nat Commun. 2021 Oct 13; 12(1):6083. view on PubMed

Wang W, Tsirulnikov K, Zhekova HR, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Zhou ZH, Pushkin A, Kurtz I. Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE. Nat Commun. 2021 09 28; 12(1):5690. view on PubMed

Li T, Xue W, Zheng Q, Song S, Yang C, Xiong H, Zhang S, Hong M, Zhang Y, Yu H, Zhang Y, Sun H, Huang Y, Deng T, Chi X, Li J, Wang S, Zhou L, Chen T, Wang Y, Cheng T, Zhang T, Yuan Q, Zhao Q, Zhang J, McLellan JS, Zhou ZH, Zhang Z, Li S, Gu Y, Xia N. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun. 2021 09 27; 12(1):5652. view on PubMed

Liu YT, Strugatsky D, Liu W, Zhou ZH. Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150. Nat Commun. 2021 09 17; 12(1):5513. view on PubMed

Ho CM, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH. Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). view on PubMed

Cai X, Liu L, Qiu C, Wen C, He Y, Cui Y, Li S, Zhang X, Zhang L, Tian C, Bi L, Zhou ZH, Gong W. Identification and architecture of a putative secretion tube across mycobacterial outer envelope. Sci Adv. 2021 08; 7(34). view on PubMed

Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. Author Correction: Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Cell Discov. 2021 Aug 06; 7(1):61. view on PubMed

Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Cell Discov. 2021 Jul 13; 7(1):51. view on PubMed

Pan M, Alvarez-Cabrera AL, Kang JS, Wang L, Fan C, Zhou ZH. Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins. Nat Commun. 2021 07 07; 12(1):4176. view on PubMed

He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J. Structures of telomerase at several steps of telomere repeat synthesis. Nature. 2021 05; 593(7859):454-459. view on PubMed

Stevens A, Muratore K, Cui Y, Johnson PJ, Zhou ZH. Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2. mBio. 2021 03 30; 12(2). view on PubMed

Terwilliger TC, Sobolev OV, Afonine PV, Adams PD, Ho CM, Li X, Zhou ZH. Protein identification from electron cryomicroscopy maps by automated model building and side-chain matching. Acta Crystallogr D Struct Biol. 2021 Apr 01; 77(Pt 4):457-462. view on PubMed

Brader ML, Williams SJ, Banks JM, Hui WH, Zhou ZH, Jin L. Encapsulation state of messenger RNA inside lipid nanoparticles. Biophys J. 2021 07 20; 120(14):2766-2770. view on PubMed

Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N. Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe. 2021 03 10; 29(3):448-462.e5. view on PubMed

Liu YT, Tao CL, Zhang X, Xia W, Shi DQ, Qi L, Xu C, Sun R, Li XW, Lau PM, Zhou ZH, Bi GQ. Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses. Nat Neurosci. 2020 12; 23(12):1589-1596. view on PubMed

Rahman SK, Kerviel A, Mohl BP, He Y, Zhou ZH, Roy P. A Calcium Sensor Discovered in Bluetongue Virus Nonstructural Protein 2 Is Critical for Virus Replication. J Virol. 2020 09 29; 94(20). view on PubMed

Wang W, Zheng Q, Pan D, Yu H, Fu W, Liu J, He M, Zhu R, Cai Y, Huang Y, Zha Z, Chen Z, Ye X, Han J, Que Y, Wu T, Zhang J, Li S, Zhu H, Zhou ZH, Cheng T, Xia N. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nat Microbiol. 2020 12; 5(12):1542-1552. view on PubMed

Wang B, Thurmond S, Zhou K, Sánchez-Aparicio MT, Fang J, Lu J, Gao L, Ren W, Cui Y, Veit EC, Hong H, Evans MJ, O'Leary SE, García-Sastre A, Zhou ZH, Hai R, Song J. Structural basis for STAT2 suppression by flavivirus NS5. Nat Struct Mol Biol. 2020 10; 27(10):875-885. view on PubMed

Liu W, Cui Y, Wang C, Li Z, Gong D, Dai X, Bi GQ, Sun R, Zhou ZH. Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus. Nat Microbiol. 2020 10; 5(10):1285-1298. view on PubMed

Draganova EB, Zhang J, Zhou ZH, Heldwein EE. Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress. Elife. 2020 06 24; 9. view on PubMed

Zhou K, Liu S, Hardenbrook NJ, Cui Y, Krantz BA, Zhou ZH. Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors. Structure. 2020 08 04; 28(8):879-887.e3. view on PubMed

Beren C, Cui Y, Chakravarty A, Yang X, Rao ALN, Knobler CM, Zhou ZH, Gelbart WM. Genome organization and interaction with capsid protein in a multipartite RNA virus. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10673-10680. view on PubMed

Das S, Ge P, Oztug Durer ZA, Grintsevich EE, Zhou ZH, Reisler E. D-loop Dynamics and Near-Atomic-Resolution Cryo-EM Structure of Phalloidin-Bound F-Actin. Structure. 2020 05 05; 28(5):586-593.e3. view on PubMed

Ge P, Scholl D, Prokhorov NS, Avaylon J, Shneider MM, Browning C, Buth SA, Plattner M, Chakraborty U, Ding K, Leiman PG, Miller JF, Zhou ZH. Action of a minimal contractile bactericidal nanomachine. Nature. 2020 04; 580(7805):658-662. view on PubMed

Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA. Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core. Nat Struct Mol Biol. 2020 05; 27(5):417-423. view on PubMed

Bucholc K, Aik WS, Yang XC, Wang K, Zhou ZH, Dadlez M, Marzluff WF, Tong L, Dominski Z. Composition and processing activity of a semi-recombinant holo U7 snRNP. Nucleic Acids Res. 2020 02 20; 48(3):1508-1530. view on PubMed

Hardenbrook NJ, Liu S, Zhou K, Ghosal K, Zhou ZH, Krantz BA. Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun. 2020 02 11; 11(1):840. view on PubMed

He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe. 2020 02 12; 27(2):249-261.e5. view on PubMed

Chen X, Cui Y, Best RB, Wang H, Zhou ZH, Yang W, Gellert M. Cutting antiparallel DNA strands in a single active site. Nat Struct Mol Biol. 2020 02; 27(2):119-126. view on PubMed

Chen X, Cui Y, Wang H, Zhou ZH, Gellert M, Yang W. How mouse RAG recombinase avoids DNA transposition. Nat Struct Mol Biol. 2020 02; 27(2):127-133. view on PubMed

Zhang Y, Liu W, Li Z, Kumar V, Alvarez-Cabrera AL, Leibovitch EC, Cui Y, Mei Y, Bi GQ, Jacobson S, Zhou ZH. Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes. Nat Commun. 2019 11 25; 10(1):5346. view on PubMed

Ho CM, Li X, Lai M, Terwilliger TC, Beck JR, Wohlschlegel J, Goldberg DE, Fitzpatrick AWP, Zhou ZH. Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu. Nat Methods. 2020 01; 17(1):79-85. view on PubMed

Imhof S, Zhang J, Wang H, Bui KH, Nguyen H, Atanasov I, Hui WH, Yang SK, Zhou ZH, Hill KL. Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei. Elife. 2019 11 11; 8. view on PubMed

Cui Y, Zhang Y, Zhou K, Sun J, Zhou ZH. Conservative transcription in three steps visualized in a double-stranded RNA virus. Nat Struct Mol Biol. 2019 11; 26(11):1023-1034. view on PubMed

Yang X, Clemens DL, Lee BY, Cui Y, Zhou ZH, Horwitz MA. Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo. Structure. 2019 12 03; 27(12):1811-1819.e6. view on PubMed

Li X, Liu S, Zhang L, Issaian A, Hill RC, Espinosa S, Shi S, Cui Y, Kappel K, Das R, Hansen KC, Zhou ZH, Zhao R. A unified mechanism for intron and exon definition and back-splicing. Nature. 2019 09; 573(7774):375-380. view on PubMed

Wongpalee SP, Liu S, Gallego-Bartolomé J, Leitner A, Aebersold R, Liu W, Yen L, Nohales MA, Kuo PH, Vashisht AA, Wohlschlegel JA, Feng S, Kay SA, Zhou ZH, Jacobsen SE. CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Nat Commun. 2019 09 02; 10(1):3916. view on PubMed

Gong D, Dai X, Jih J, Liu YT, Bi GQ, Sun R, Zhou ZH. DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV. Cell. 2019 09 05; 178(6):1329-1343.e12. view on PubMed

He Y, Shivakoti S, Ding K, Cui Y, Roy P, Zhou ZH. In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16535-16540. view on PubMed

Olsen RW, Lindemeyer AK, Wallner M, Li X, Huynh KW, Zhou ZH. Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery. Ann Transl Med. 2019 Jul; 7(Suppl 3):S144. view on PubMed

Liu YT, Jih J, Dai X, Bi GQ, Zhou ZH. Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature. 2019 06; 570(7760):257-261. view on PubMed

Ding K, Celma CC, Zhang X, Chang T, Shen W, Atanasov I, Roy P, Zhou ZH. In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Nat Commun. 2019 05 17; 10(1):2216. view on PubMed

Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P. Structure of the human ClC-1 chloride channel. PLoS Biol. 2019 04; 17(4):e3000218. view on PubMed

Liu YT, Tao CL, Lau PM, Zhou ZH, Bi GQ. Postsynaptic protein organization revealed by electron microscopy. Curr Opin Struct Biol. 2019 02; 54:152-160. view on PubMed

Cui Y, Zhou K, Strugatsky D, Wen Y, Sachs G, Zhou ZH, Munson K. pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM. Sci Adv. 2019 03; 5(3):eaav8423. view on PubMed

Liu W, Dai X, Jih J, Chan K, Trang P, Yu X, Balogun R, Mei Y, Liu F, Zhou ZH. Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. PLoS Pathog. 2019 02; 15(2):e1007615. view on PubMed

Kerviel A, Ge P, Lai M, Jih J, Boyce M, Zhang X, Zhou ZH, Roy P. Atomic structure of the translation regulatory protein NS1 of bluetongue virus. Nat Microbiol. 2019 05; 4(5):837-845. view on PubMed

Gao Y, Cui Y, Fox T, Lin S, Wang H, de Val N, Zhou ZH, Yang W. Structures and operating principles of the replisome. Science. 2019 02 22; 363(6429). view on PubMed

Si Z, Zhang J, Shivakoti S, Atanasov I, Tao CL, Hui WH, Zhou K, Yu X, Li W, Luo M, Bi GQ, Zhou ZH. Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate. PLoS Pathog. 2018 12; 14(12):e1007452. view on PubMed

Zheng Q, Zhu R, Xu L, He M, Yan X, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS, Cheng T, Li S, Xia N. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nat Microbiol. 2019 01; 4(1):124-133. view on PubMed

Kappel K, Liu S, Larsen KP, Skiniotis G, Puglisi EV, Puglisi JD, Zhou ZH, Zhao R, Das R. De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes. Nat Methods. 2018 11; 15(11):947-954. view on PubMed

Ding K, Nguyen L, Zhou ZH. In Situ Structures of the Polymerase Complex and RNA Genome Show How Aquareovirus Transcription Machineries Respond to Uncoating. J Virol. 2018 11 01; 92(21). view on PubMed

Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY. Structural insights on TRPV5 gating by endogenous modulators. Nat Commun. 2018 10 10; 9(1):4198. view on PubMed

Zhu R, Xu L, Zheng Q, Cui Y, Li S, He M, Yin Z, Liu D, Li S, Li Z, Chen Z, Yu H, Que Y, Liu C, Kong Z, Zhang J, Baker TS, Yan X, Hong Zhou Z, Cheng T, Xia N. Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv. 2018 09; 4(9):eaat7459. view on PubMed

Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun. 2018 09 06; 9(1):3609. view on PubMed

Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH. Malaria parasite translocon structure and mechanism of effector export. Nature. 2018 09; 561(7721):70-75. view on PubMed

Liu S, Xu L, Guan F, Liu YT, Cui Y, Zhang Q, Zheng X, Bi GQ, Zhou ZH, Zhang X, Ye S. Cryo-EM structure of the human α5β3 GABAA receptor. Cell Res. 2018 09; 28(9):958-961. view on PubMed

Yu I, Nguyen L, Avaylon J, Wang K, Lai M, Zhou ZH. Building atomic models based on near atomic resolution cryoEM maps with existing tools. J Struct Biol. 2018 11; 204(2):313-318. view on PubMed

Tao CL, Liu YT, Zhou ZH, Lau PM, Bi GQ. Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. Front Neuroanat. 2018; 12:48. view on PubMed

Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, Feigon J. Structure of Telomerase with Telomeric DNA. Cell. 2018 05 17; 173(5):1179-1190.e13. view on PubMed

Jiang J, Baiesc FL, Hiromasa Y, Yu X, Hui WH, Dai X, Roche TE, Zhou ZH. Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex. Biochemistry. 2018 04 24; 57(16):2325-2334. view on PubMed

Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. Author Correction: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2018 04 11; 9(1):1495. view on PubMed

Kim MS, Chuenchor W, Chen X, Cui Y, Zhang X, Zhou ZH, Gellert M, Yang W. Cracking the DNA Code for V(D)J Recombination. Mol Cell. 2018 04 19; 70(2):358-370.e4. view on PubMed

Dai X, Zhou ZH. Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes. Science. 2018 04 06; 360(6384). view on PubMed

Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH. Solution Structures of Engineered Vault Particles. Structure. 2018 04 03; 26(4):619-626.e3. view on PubMed

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat Struct Mol Biol. 2018 04; 25(4):311-319. view on PubMed

Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH, Kurtz I. CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1. Nat Commun. 2018 03 02; 9(1):900. view on PubMed

Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W, Amarasinghe GK. Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell. 2018 02 22; 172(5):966-978.e12. view on PubMed

Tian T, Li X, Liu Y, Wang C, Liu X, Bi G, Zhang X, Yao X, Zhou ZH, Zang J. Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore. Cell Res. 2018 Mar; 28(3):374-378. view on PubMed

Dai X, Gong D, Lim H, Jih J, Wu TT, Sun R, Zhou ZH. Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication. Nature. 2018 01 25; 553(7689):521-525. view on PubMed

Park K, Kuo Y, Shvadchak V, Ingargiola A, Dai X, Hsiung L, Kim W, Zhou H, Zou P, Levine AJ, Li J, Weiss S. Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration. Sci Adv. 2018 01; 4(1):e1601453. view on PubMed

Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, Tian CL, Zhang P, Lau PM, Zhou ZH, Bi GQ. Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy. J Neurosci. 2018 02 07; 38(6):1493-1510. view on PubMed

Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat Struct Mol Biol. 2018 01; 25(1):53-60. view on PubMed

Grintsevich EE, Ge P, Sawaya MR, Yesilyurt HG, Terman JR, Zhou ZH, Reisler E. Catastrophic disassembly of actin filaments via Mical-mediated oxidation. Nat Commun. 2017 12 19; 8(1):2183. view on PubMed

Dai X, Wu L, Sun R, Zhou ZH. Atomic Structures of Minor Proteins VI and VII in Human Adenovirus. J Virol. 2017 12 15; 91(24). view on PubMed

Liu S, Li X, Zhang L, Jiang J, Hill RC, Cui Y, Hansen KC, Zhou ZH, Zhao R. Structure of the yeast spliceosomal postcatalytic P complex. Science. 2017 12 08; 358(6368):1278-1283. view on PubMed

Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017 10 19; 8(1):1035. view on PubMed

Liu YT, Jiang J, Bohannon KP, Dai X, Gant Luxton GW, Hui WH, Bi GQ, Smith GA, Zhou ZH. A pUL25 dimer interfaces the pseudorabies virus capsid and tegument. J Gen Virol. 2017 11; 98(11):2837-2849. view on PubMed

Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ. Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation. J Am Chem Soc. 2017 10 25; 139(42):15114-15121. view on PubMed

Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS. Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. Nat Commun. 2017 10 03; 8(1):781. view on PubMed

Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS. Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8703-E8710. view on PubMed

Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T, Zhou ZH, Yan X, Xia N. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nat Commun. 2017 09 11; 8(1):505. view on PubMed

Alewijnse B, Ashton AW, Chambers MG, Chen S, Cheng A, Ebrahim M, Eng ET, Hagen WJH, Koster AJ, López CS, Lukoyanova N, Ortega J, Renault L, Reyntjens S, Rice WJ, Scapin G, Schrijver R, Siebert A, Stagg SM, Grum-Tokars V, Wright ER, Wu S, Yu Z, Zhou ZH, Carragher B, Potter CS. Best practices for managing large CryoEM facilities. J Struct Biol. 2017 09; 199(3):225-236. view on PubMed

Yu X, Jih J, Jiang J, Zhou ZH. Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150. Science. 2017 06 30; 356(6345). view on PubMed

Dai X, Li Z, Lai M, Shu S, Du Y, Zhou ZH, Sun R. In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. Nature. 2017 01 05; 541(7635):112-116. view on PubMed

Poweleit N, Ge P, Nguyen HH, Loo RR, Gunsalus RP, Zhou ZH. CryoEM structure of the Methanospirillum hungatei archaellum reveals structural features distinct from the bacterial flagellum and type IV pilus. Nat Microbiol. 2016 12 05; 2:16222. view on PubMed

Zhang X, Lai M, Chang W, Yu I, Ding K, Mrazek J, Ng HL, Yang OO, Maslov DA, Zhou ZH. Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun. 2016 10 18; 7:13223. view on PubMed

Mayle KM, Dern KR, Wong VK, Chen KY, Sung S, Ding K, Rodriguez AR, Knowles S, Taylor Z, Zhou ZH, Grundfest WS, Wu AM, Deming TJ, Kamei DT. Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy. SLAS Technol. 2017 02; 22(1):26-35. view on PubMed

Lee G, Chakraborty U, Gebhart D, Govoni GR, Zhou ZH, Scholl D. F-Type Bacteriocins of Listeria monocytogenes: a New Class of Phage Tail-Like Structures Reveals Broad Parallel Coevolution between Tailed Bacteriophages and High-Molecular-Weight Bacteriocins. J Bacteriol. 2016 10 15; 198(20):2784-93. view on PubMed

Mayle KM, Dern KR, Wong VK, Sung S, Ding K, Rodriguez AR, Taylor Z, Zhou ZH, Grundfest WS, Deming TJ, Kamei DT. Polypeptide-Based Gold Nanoshells for Photothermal Therapy. SLAS Technol. 2017 02; 22(1):18-25. view on PubMed

Huber RC, Ferreira AS, Aguirre JC, Kilbride D, Toso DB, Mayoral K, Zhou ZH, Kopidakis N, Rubin Y, Schwartz BJ, Mason TG, Tolbert SH. Structure and Conductivity of Semiconducting Polymer Hydrogels. J Phys Chem B. 2016 07 07; 120(26):6215-24. view on PubMed

Toso DB, Javed MM, Czornyj E, Gunsalus RP, Zhou ZH. Discovery and Characterization of Iron Sulfide and Polyphosphate Bodies Coexisting in Archaeoglobus fulgidus Cells. Archaea. 2016; 2016:4706532. view on PubMed

Huynh KW, Cohen MR, Jiang J, Samanta A, Lodowski DT, Zhou ZH, Moiseenkova-Bell VY. Structure of the full-length TRPV2 channel by cryo-EM. Nat Commun. 2016 Mar 29; 7:11130. view on PubMed

Gunsalus RP, Cook LE, Crable B, Rohlin L, McDonald E, Mouttaki H, Sieber JR, Poweleit N, Zhou H, Lapidus AL, Daligault HE, Land M, Gilna P, Ivanova N, Kyrpides N, Culley DE, McInerney MJ. Complete genome sequence of Methanospirillum hungatei type strain JF1. Stand Genomic Sci. 2016; 11:2. view on PubMed

Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. PLoS Pathog. 2015 Dec; 11(12):e1005322. view on PubMed

Zhang X, Patel A, Celma CC, Yu X, Roy P, Zhou ZH. Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry. Nat Struct Mol Biol. 2016 Jan; 23(1):74-80. view on PubMed

Bor B, Poweleit N, Bois JS, Cen L, Bedree JK, Zhou ZH, Gunsalus RP, Lux R, McLean JS, He X, Shi W. Phenotypic and Physiological Characterization of the Epibiotic Interaction Between TM7x and Its Basibiont Actinomyces. Microb Ecol. 2016 Jan; 71(1):243-55. view on PubMed

Jurado AR, Huang CS, Zhang X, Zhou ZH, Tong L. Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase. Nat Commun. 2015 Nov 23; 6:8986. view on PubMed

Volland S, Hughes LC, Kong C, Burgess BL, Linberg KA, Luna G, Zhou ZH, Fisher SK, Williams DS. Three-dimensional organization of nascent rod outer segment disk membranes. Proc Natl Acad Sci U S A. 2015 Dec 01; 112(48):14870-5. view on PubMed

Zhang X, Ding K, Yu X, Chang W, Sun J, Zhou ZH. In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. Nature. 2015 Nov 26; 527(7579):531-534. view on PubMed

Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J. Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science. 2015 Oct 30; 350(6260):aab4070. view on PubMed

Yu X, Jiang J, Sun J, Zhou ZH. A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife. 2015 Aug 04; 4:e07901. view on PubMed

Kaweeteerawat C, Chang CH, Roy KR, Liu R, Li R, Toso D, Fischer H, Ivask A, Ji Z, Zink JI, Zhou ZH, Chanfreau GF, Telesca D, Cohen Y, Holden PA, Nel AE, Godwin HA. Cu Nanoparticles Have Different Impacts in Escherichia coli and Lactobacillus brevis than Their Microsized and Ionic Analogues. ACS Nano. 2015 Jul 28; 9(7):7215-25. view on PubMed

Huber RC, Ferreira AS, Thompson R, Kilbride D, Knutson NS, Devi LS, Toso DB, Challa JR, Zhou ZH, Rubin Y, Schwartz BJ, Tolbert SH. POLARON DYNAMICS. Long-lived photoinduced polaron formation in conjugated polyelectrolyte-fullerene assemblies. Science. 2015 Jun 19; 348(6241):1340-3. view on PubMed

Zhou ZH, Chiou J. Protein chainmail variants in dsDNA viruses. AIMS Biophys. 2015; 2(2):200-218. view on PubMed

AhYoung AP, Jiang J, Zhang J, Khoi Dang X, Loo JA, Zhou ZH, Egea PF. Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):E3179-88. view on PubMed

Ge P, Scholl D, Leiman PG, Yu X, Miller JF, Zhou ZH. Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states. Nat Struct Mol Biol. 2015 May; 22(5):377-82. view on PubMed

Jiang J, Pentelute BL, Collier RJ, Zhou ZH. Atomic structure of anthrax protective antigen pore elucidates toxin translocation. Nature. 2015 May 28; 521(7553):545-9. view on PubMed

Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH. Atomic structure of T6SS reveals interlaced array essential to function. Cell. 2015 Feb 26; 160(5):940-951. view on PubMed

Dai X, Gong D, Xiao Y, Wu TT, Sun R, Zhou ZH. CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E649-56. view on PubMed

Dejnirattisai W, Wongwiwat W, Supasa S, Zhang X, Dai X, Rouvinski A, Jumnainsong A, Edwards C, Quyen NTH, Duangchinda T, Grimes JM, Tsai WY, Lai CY, Wang WK, Malasit P, Farrar J, Simmons CP, Zhou ZH, Rey FA, Mongkolsapaya J, Screaton GR. A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus. Nat Immunol. 2015 Feb; 16(2):170-177. view on PubMed

Ren S, Lu G, Ota A, Zhou ZH, Vondriska TM, Lane TF, Wang Y. IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. PLoS One. 2014; 9(11):e111606. view on PubMed

Ge P, Durer ZA, Kudryashov D, Zhou ZH, Reisler E. Cryo-EM reveals different coronin binding modes for ADP- and ADP-BeFx actin filaments. Nat Struct Mol Biol. 2014 Dec; 21(12):1075-81. view on PubMed

Mrazek J, Toso D, Ryazantsev S, Zhang X, Zhou ZH, Fernandez BC, Kickhoefer VA, Rome LH. Polyribosomes are molecular 3D nanoprinters that orchestrate the assembly of vault particles. ACS Nano. 2014 Nov 25; 8(11):11552-9. view on PubMed

Zhou ZH, Hui WH, Shah S, Jih J, O'Connor CM, Sherman MB, Kedes DH, Schein S. Four levels of hierarchical organization, including noncovalent chainmail, brace the mature tumor herpesvirus capsid against pressurization. Structure. 2014 Oct 07; 22(10):1385-98. view on PubMed

Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS. Assembly and architecture of the EBV B cell entry triggering complex. PLoS Pathog. 2014 Aug; 10(8):e1004309. view on PubMed

Dai X, Gong D, Wu TT, Sun R, Zhou ZH. Organization of capsid-associated tegument components in Kaposi's sarcoma-associated herpesvirus. J Virol. 2014 Nov; 88(21):12694-702. view on PubMed

Dai X, Zhou ZH. Purification of Herpesvirus Virions and Capsids. Bio Protoc. 2014 Aug 05; 4(15). view on PubMed

Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS Nano. 2014 Aug 26; 8(8):7723-32. view on PubMed

Zhou ZH. Structures of viral membrane proteins by high-resolution cryoEM. Curr Opin Virol. 2014 Apr; 5:111-9. view on PubMed

Yan X, Cardone G, Zhang X, Zhou ZH, Baker TS. Single particle analysis integrated with microscopy: a high-throughput approach for reconstructing icosahedral particles. J Struct Biol. 2014 Apr; 186(1):8-18. view on PubMed

Yang K, Wills E, Lim HY, Zhou ZH, Baines JD. Association of herpes simplex virus pUL31 with capsid vertices and components of the capsid vertex-specific complex. J Virol. 2014 Apr; 88(7):3815-25. view on PubMed

Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN. INF2-mediated severing through actin filament encirclement and disruption. Curr Biol. 2014 Jan 20; 24(2):156-164. view on PubMed

Ge P, Zhou ZH. Chaperone fusion proteins aid entropy-driven maturation of class II viral fusion proteins. Trends Microbiol. 2014 Feb; 22(2):100-6. view on PubMed

Zhang X, Guo H, Jin L, Czornyj E, Hodes A, Hui WH, Nieh AW, Miller JF, Zhou ZH. A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 A resolution. Elife. 2013 Dec 17; 2:e01299. view on PubMed

Yu X, Jin L, Jih J, Shih C, Zhou ZH. 3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein. PLoS One. 2013; 8(9):e69729. view on PubMed

Hui WH, Tang Q, Liu H, Atanasov I, Liu F, Zhu H, Zhou ZH. Protein interactions in the murine cytomegalovirus capsid revealed by cryoEM. Protein Cell. 2013 Nov; 4(11):833-45. view on PubMed

Dai X, Yu X, Gong H, Jiang X, Abenes G, Liu H, Shivakoti S, Britt WJ, Zhu H, Liu F, Zhou ZH. The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus. PLoS Pathog. 2013 Aug; 9(8):e1003525. view on PubMed

Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K. Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Mol Cell Biol. 2013 Oct; 33(19):3962-71. view on PubMed

Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y. PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2013; 2(4):405-16. view on PubMed

Jiang J, Miracco EJ, Hong K, Eckert B, Chan H, Cash DD, Min B, Zhou ZH, Collins K, Feigon J. The architecture of Tetrahymena telomerase holoenzyme. Nature. 2013 Apr 11; 496(7444):187-92. view on PubMed

Jiang J, Magilnick N, Tsirulnikov K, Abuladze N, Atanasov I, Ge P, Narla M, Pushkin A, Zhou ZH, Kurtz I. Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains. PLoS One. 2013; 8(2):e55408. view on PubMed

Zhang X, Ge P, Yu X, Brannan JM, Bi G, Zhang Q, Schein S, Zhou ZH. Cryo-EM structure of the mature dengue virus at 3.5-Å resolution. Nat Struct Mol Biol. 2013 Jan; 20(1):105-10. view on PubMed

Jiang ZK, Koh SB, Sato M, Atanasov IC, Johnson M, Zhou ZH, Deming TJ, Wu L. Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses. J Control Release. 2013 Feb 28; 166(1):75-85. view on PubMed

Xiao Q, Sohn H, Chen Z, Toso D, Mechlenburg M, Zhou ZH, Poirier E, Dailly A, Wang H, Wu Z, Cai M, Lu Y. Mesoporous metal and metal alloy particles synthesized by aerosol-assisted confined growth of nanocrystals. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10546-50. view on PubMed

Zhou ZH. Seeing engineered loops in a gene delivery vehicle by cryoEM. Structure. 2012 Aug 08; 20(8):1286-8. view on PubMed

Zhang X, Guo H, Jin L, Xu M, Miller JF, Zhou ZH. Atomic Structure of Bordetella Bacteriophage Reveals a Jellyroll Fold in CementProtein and a Topologically Distinct HK97-like Fold in Major Capsid Protein. Microsc Microanal. 2012 Jul; 18(Suppl 2):72-73. view on PubMed

Luo J, Obmolova G, Malia TJ, Wu SJ, Duffy KE, Marion JD, Bell JK, Ge P, Zhou ZH, Teplyakov A, Zhao Y, Lamb RJ, Jordan JL, San Mateo LR, Sweet RW, Gilliland GL. Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure. J Mol Biol. 2012 Aug 03; 421(1):112-24. view on PubMed

Hughes LC, Ralston KS, Hill KL, Zhou ZH. Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. PLoS One. 2012; 7(1):e25700. view on PubMed

Gopal A, Zhou ZH, Knobler CM, Gelbart WM. Visualizing large RNA molecules in solution. RNA. 2012 Feb; 18(2):284-99. view on PubMed

Huang CS, Ge P, Zhou ZH, Tong L. An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase. Nature. 2011 Dec 11; 481(7380):219-23. view on PubMed

Toso DB, Henstra AM, Gunsalus RP, Zhou ZH. Structural, mass and elemental analyses of storage granules in methanogenic archaeal cells. Environ Microbiol. 2011 Sep; 13(9):2587-99. view on PubMed

Zhang X, Zhou ZH. Limiting factors in atomic resolution cryo electron microscopy: no simple tricks. J Struct Biol. 2011 Sep; 175(3):253-63. view on PubMed

Ge P, Zhou ZH. Hydrogen-bonding networks and RNA bases revealed by cryo electron microscopy suggest a triggering mechanism for calcium switches. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9637-42. view on PubMed

Yu X, Ge P, Jiang J, Atanasov I, Zhou ZH. Atomic model of CPV reveals the mechanism used by this single-shelled virus to economically carry out functions conserved in multishelled reoviruses. Structure. 2011 May 11; 19(5):652-61. view on PubMed

Buehler DC, Toso DB, Kickhoefer VA, Zhou ZH, Rome LH. Vaults engineered for hydrophobic drug delivery. Small. 2011 May 23; 7(10):1432-9. view on PubMed

Yang Z, Hu W, Chen K, Wang J, Lux R, Zhou ZH, Shi W. Alanine 32 in PilA is important for PilA stability and type IV pili function in Myxococcus xanthus. Microbiology (Reading). 2011 Jul; 157(Pt 7):1920-1928. view on PubMed

Chen J, Sun J, Atanasov I, Ryazantsev S, Zhou ZH. Electron tomography reveals polyhedrin binding and existence of both empty and full cytoplasmic polyhedrosis virus particles inside infectious polyhedra. J Virol. 2011 Jun; 85(12):6077-81. view on PubMed

Yu X, Shah S, Lee M, Dai W, Lo P, Britt W, Zhu H, Liu F, Zhou ZH. Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus. J Struct Biol. 2011 Jun; 174(3):451-60. view on PubMed

Zhou ZH. Atomic resolution cryo electron microscopy of macromolecular complexes. Adv Protein Chem Struct Biol. 2011; 82:1-35. view on PubMed

Green TJ, Rowse M, Tsao J, Kang J, Ge P, Zhou ZH, Luo M. Access to RNA encapsidated in the nucleocapsid of vesicular stomatitis virus. J Virol. 2011 Mar; 85(6):2714-22. view on PubMed

Liu H, Wu L, Zhou ZH. Model of the trimeric fiber and its interactions with the pentameric penton base of human adenovirus by cryo-electron microscopy. J Mol Biol. 2011 Mar 11; 406(5):764-74. view on PubMed

Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells. J Biol Chem. 2011 Feb 04; 286(5):3261-9. view on PubMed

Liu J, Howell JK, Bradley SD, Zheng Y, Zhou ZH, Norris SJ. Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. J Mol Biol. 2010 Nov 05; 403(4):546-61. view on PubMed

Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH. Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science. 2010 Aug 27; 329(5995):1038-43. view on PubMed

Huang CS, Sadre-Bazzaz K, Shen Y, Deng B, Zhou ZH, Tong L. Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase. Nature. 2010 Aug 19; 466(7309):1001-5. view on PubMed

Faller M, Toso D, Matsunaga M, Atanasov I, Senturia R, Chen Y, Zhou ZH, Guo F. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA. 2010 Aug; 16(8):1570-83. view on PubMed

Zhang X, Zhang X, Zhou ZH. Low cost, high performance GPU computing solution for atomic resolution cryoEM single-particle reconstruction. J Struct Biol. 2010 Dec; 172(3):400-6. view on PubMed

Zhang X, Jin L, Fang Q, Hui WH, Zhou ZH. 3.3 A cryo-EM structure of a nonenveloped virus reveals a priming mechanism for cell entry. Cell. 2010 Apr 30; 141(3):472-82. view on PubMed

Zhang X, Boyce M, Bhattacharya B, Zhang X, Schein S, Roy P, Zhou ZH. Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6292-7. view on PubMed

Dai W, Hodes A, Hui WH, Gingery M, Miller JF, Zhou ZH. Three-dimensional structure of tropism-switching Bordetella bacteriophage. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4347-52. view on PubMed

Liu S, He J, Shih C, Li K, Dai A, Zhou ZH, Zhang J. Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths. Virus Res. 2010 May; 149(2):241-4. view on PubMed

Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH. Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Science. 2010 Feb 05; 327(5966):689-93. view on PubMed

Zhu J, Cheng L, Fang Q, Zhou ZH, Honig B. Building and refining protein models within cryo-electron microscopy density maps based on homology modeling and multiscale structure refinement. J Mol Biol. 2010 Apr 02; 397(3):835-51. view on PubMed

Peng L, Ryazantsev S, Sun R, Zhou ZH. Three-dimensional visualization of gammaherpesvirus life cycle in host cells by electron tomography. Structure. 2010 Jan 13; 18(1):47-58. view on PubMed

Leong PA, Yu X, Zhou ZH, Jensen GJ. Correcting for the ewald sphere in high-resolution single-particle reconstructions. Methods Enzymol. 2010; 482:369-80. view on PubMed

Cheng L, Zhu J, Hui WH, Zhang X, Honig B, Fang Q, Zhou ZH. Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics. J Mol Biol. 2010 Apr 02; 397(3):852-63. view on PubMed

Yan M, Du J, Gu Z, Liang M, Hu Y, Zhang W, Priceman S, Wu L, Zhou ZH, Liu Z, Segura T, Tang Y, Lu Y. A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol. 2010 Jan; 5(1):48-53. view on PubMed

Guo H, Wang L, Peng L, Zhou ZH, Deng H. Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. J Virol. 2009 Oct; 83(20):10582-95. view on PubMed

Li F, Ge P, Hui WH, Atanasov I, Rogers K, Guo Q, Osato D, Falick AM, Zhou ZH, Simpson L. Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12306-10. view on PubMed

Nayak DP, Balogun RA, Yamada H, Zhou ZH, Barman S. Influenza virus morphogenesis and budding. Virus Res. 2009 Aug; 143(2):147-61. view on PubMed

Song C, Jiang H, Mancuso A, Amirbekian B, Peng L, Sun R, Shah SS, Zhou ZH, Ishikawa T, Miao J. Quantitative imaging of single, unstained viruses with coherent x rays. Phys Rev Lett. 2008 Oct 10; 101(15):158101. view on PubMed

Jiang J, Zhang X, Chen Y, Wu Y, Zhou ZH, Chang Z, Sui SF. Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11939-44. view on PubMed

Cheng L, Fang Q, Shah S, Atanasov IC, Zhou ZH. Subnanometer-resolution structures of the grass carp reovirus core and virion. J Mol Biol. 2008 Sep 26; 382(1):213-22. view on PubMed

Yu X, Jin L, Zhou ZH. 3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy. Nature. 2008 May 15; 453(7193):415-9. view on PubMed

Zhou ZH. Towards atomic resolution structural determination by single-particle cryo-electron microscopy. Curr Opin Struct Biol. 2008 Apr; 18(2):218-28. view on PubMed

Yu X, Hiromasa Y, Tsen H, Stoops JK, Roche TE, Zhou ZH. Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains. Structure. 2008 Jan; 16(1):104-14. view on PubMed

Dai W, Jia Q, Bortz E, Shah S, Liu J, Atanasov I, Li X, Taylor KA, Sun R, Zhou ZH. Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy. J Struct Biol. 2008 Mar; 161(3):428-38. view on PubMed

Deng B, O'Connor CM, Kedes DH, Zhou ZH. Cryo-electron tomography of Kaposi's sarcoma-associated herpesvirus capsids reveals dynamic scaffolding structures essential to capsid assembly and maturation. J Struct Biol. 2008 Mar; 161(3):419-27. view on PubMed

Liu H, Cheng L, Zeng S, Cai C, Zhou ZH, Yang Q. Symmetry-adapted spherical harmonics method for high-resolution 3D single-particle reconstructions. J Struct Biol. 2008 Jan; 161(1):64-73. view on PubMed

Bortz E, Wang L, Jia Q, Wu TT, Whitelegge JP, Deng H, Zhou ZH, Sun R. Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm. J Virol. 2007 Sep; 81(18):10137-50. view on PubMed

Yu X, Qiao M, Atanasov I, Hu Z, Kato T, Liang TJ, Zhou ZH. Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles. Virology. 2007 Oct 10; 367(1):126-34. view on PubMed

Cheng L, Chen S, Zhou ZH, Zhang J. Structure comparisons of Aedes albopictus densovirus with other parvoviruses. Sci China C Life Sci. 2007 Feb; 50(1):70-4. view on PubMed

Deng B, O'Connor CM, Kedes DH, Zhou ZH. Direct visualization of the putative portal in the Kaposi's sarcoma-associated herpesvirus capsid by cryoelectron tomography. J Virol. 2007 Apr; 81(7):3640-4. view on PubMed

Liu F, Zhou ZH. Comparative virion structures of human herpesviruses. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. 2007. view on PubMed

Cong Y, Jiang W, Birmanns S, Zhou ZH, Chiu W, Wriggers W. Fast rotational matching of single-particle images. J Struct Biol. 2005 Nov; 152(2):104-12. view on PubMed

Yu X, Trang P, Shah S, Atanasov I, Kim YH, Bai Y, Zhou ZH, Liu F. Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopy. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7103-8. view on PubMed

Yu X, Shah S, Atanasov I, Lo P, Liu F, Britt WJ, Zhou ZH. Three-dimensional localization of the smallest capsid protein in the human cytomegalovirus capsid. J Virol. 2005 Jan; 79(2):1327-32. view on PubMed

Qiao M, Ashok M, Bernard KA, Palacios G, Zhou ZH, Lipkin WI, Liang TJ. Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cells. J Infect Dis. 2004 Dec 15; 190(12):2104-8. view on PubMed

Booth CR, Jiang W, Baker ML, Zhou ZH, Ludtke SJ, Chiu W. A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope. J Struct Biol. 2004 Aug; 147(2):116-27. view on PubMed

Cheng L, Chen S, Brannan JM, Jakana J, Zhang Q, Zhou ZH, Zhang J. Three-dimensional structure determination of capsid of Aedes albopictus C6/36 cell densovirus. Sci China C Life Sci. 2004 Jun; 47(3):224-8. view on PubMed

Chen S, Cheng L, Zhang Q, Lin W, Lu X, Brannan J, Zhou ZH, Zhang J. Genetic, biochemical, and structural characterization of a new densovirus isolated from a chronically infected Aedes albopictus C6/36 cell line. Virology. 2004 Jan 05; 318(1):123-33. view on PubMed

Bortz E, Whitelegge JP, Jia Q, Zhou ZH, Stewart JP, Wu TT, Sun R. Identification of proteins associated with murine gammaherpesvirus 68 virions. J Virol. 2003 Dec; 77(24):13425-32. view on PubMed

Yu XK, O'Connor CM, Atanasov I, Damania B, Kedes DH, Zhou ZH. Three-dimensional structures of the A, B, and C capsids of rhesus monkey rhadinovirus: insights into gammaherpesvirus capsid assembly, maturation, and DNA packaging. J Virol. 2003 Dec; 77(24):13182-93. view on PubMed

Dai W, Liang Y, Zhou ZH. Web portal to an image database for high-resolution three-dimensional reconstruction. J Struct Biol. 2003 Oct-Nov; 144(1-2):238-45. view on PubMed

Baker ML, Jiang W, Bowman BR, Zhou ZH, Quiocho FA, Rixon FJ, Chiu W. Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. J Mol Biol. 2003 Aug 08; 331(2):447-56. view on PubMed

Kong Y, Ming D, Wu Y, Stoops JK, Zhou ZH, Ma J. Conformational flexibility of pyruvate dehydrogenase complexes: a computational analysis by quantized elastic deformational model. J Mol Biol. 2003 Jun 27; 330(1):129-35. view on PubMed

Zhou ZH, Zhang H, Jakana J, Lu XY, Zhang JQ. Cytoplasmic polyhedrosis virus structure at 8 A by electron cryomicroscopy: structural basis of capsid stability and mRNA processing regulation. Structure. 2003 Jun; 11(6):651-63. view on PubMed

Gu Y, Zhou ZH, McCarthy DB, Reed LJ, Stoops JK. 3D electron microscopy reveals the variable deposition and protein dynamics of the peripheral pyruvate dehydrogenase component about the core. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7015-20. view on PubMed

Lo P, Yu X, Atanasov I, Chandran B, Zhou ZH. Three-dimensional localization of pORF65 in Kaposi's sarcoma-associated herpesvirus capsid. J Virol. 2003 Apr; 77(7):4291-7. view on PubMed

Lu BY, Atanasov I, Zhou ZH, Chang JY. Reversible aggregation of mouse prion protein derivatives with PrPSC-like structural properties. J Protein Chem. 2003 Feb; 22(2):115-26. view on PubMed

Zhou ZH, Chiu W. Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution. Adv Protein Chem. 2003; 64:93-124. view on PubMed

Xia Q, Jakana J, Zhang JQ, Zhou ZH. Structural comparisons of empty and full cytoplasmic polyhedrosis virus. Protein-RNA interactions and implications for endogenous RNA transcription mechanism. J Biol Chem. 2003 Jan 10; 278(2):1094-100. view on PubMed

Zhang H, Yu XK, Lu XY, Zhang JQ, Zhou ZH. Molecular interactions and viral stability revealed by structural analyses of chemically treated cypovirus capsids. Virology. 2002 Jun 20; 298(1):45-52. view on PubMed

Chiu W, Baker ML, Jiang W, Zhou ZH. Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches. Curr Opin Struct Biol. 2002 Apr; 12(2):263-9. view on PubMed

Liang Y, Ke EY, Zhou ZH. IMIRS: a high-resolution 3D reconstruction package integrated with a relational image database. J Struct Biol. 2002 Mar; 137(3):292-304. view on PubMed

Zhou ZH, McCarthy DB, O'Connor CM, Reed LJ, Stoops JK. The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):14802-7. view on PubMed

Chen DH, Jakana J, McNab D, Mitchell J, Zhou ZH, Dougherty M, Chiu W, Rixon FJ. The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon-associated protein VP26. J Virol. 2001 Dec; 75(23):11863-7. view on PubMed

Zhou ZH, Baker ML, Jiang W, Dougherty M, Jakana J, Dong G, Lu G, Chiu W. Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virus. Nat Struct Biol. 2001 Oct; 8(10):868-73. view on PubMed

He J, Schmid MF, Zhou ZH, Rixon F, Chiu W. Finding and using local symmetry in identifying lower domain movements in hexon subunits of the herpes simplex virus type 1 B capsid. J Mol Biol. 2001 Jun 15; 309(4):903-14. view on PubMed

Zhou ZH, Liao W, Cheng RH, Lawson JE, McCarthy DB, Reed LJ, Stoops JK. Direct evidence for the size and conformational variability of the pyruvate dehydrogenase complex revealed by three-dimensional electron microscopy. The "breathing" core and its functional relationship to protein dynamics. J Biol Chem. 2001 Jun 15; 276(24):21704-13. view on PubMed

Wu L, Lo P, Yu X, Stoops JK, Forghani B, Zhou ZH. Three-dimensional structure of the human herpesvirus 8 capsid. J Virol. 2000 Oct; 74(20):9646-54. view on PubMed

Zhou ZH, Dougherty M, Jakana J, He J, Rixon FJ, Chiu W. Seeing the herpesvirus capsid at 8.5 A. Science. 2000 May 05; 288(5467):877-80. view on PubMed

Saad A, Zhou ZH, Jakana J, Chiu W, Rixon FJ. Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles. J Virol. 1999 Aug; 73(8):6821-30. view on PubMed

Chen DH, Jiang H, Lee M, Liu F, Zhou ZH. Three-dimensional visualization of tegument/capsid interactions in the intact human cytomegalovirus. Virology. 1999 Jul 20; 260(1):10-6. view on PubMed

Zhou ZH, Chen DH, Jakana J, Rixon FJ, Chiu W. Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions. J Virol. 1999 Apr; 73(4):3210-8. view on PubMed

Zhang H, Zhang J, Yu X, Lu X, Zhang Q, Jakana J, Chen DH, Zhang X, Zhou ZH. Visualization of protein-RNA interactions in cytoplasmic polyhedrosis virus. J Virol. 1999 Feb; 73(2):1624-9. view on PubMed

Lu G, Zhou ZH, Baker ML, Jakana J, Cai D, Wei X, Chen S, Gu X, Chiu W. Structure of double-shelled rice dwarf virus. J Virol. 1998 Nov; 72(11):8541-9. view on PubMed

Zhou ZH, Macnab SJ, Jakana J, Scott LR, Chiu W, Rixon FJ. Identification of the sites of interaction between the scaffold and outer shell in herpes simplex virus-1 capsids by difference electron imaging. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2778-83. view on PubMed

Zhou ZH, Chiu W, Haskell K, Spears H, Jakana J, Rixon FJ, Scott LR. Refinement of herpesvirus B-capsid structure on parallel supercomputers. Biophys J. 1998 Jan; 74(1):576-88. view on PubMed

Stoops JK, Cheng RH, Yazdi MA, Maeng CY, Schroeter JP, Klueppelberg U, Kolodziej SJ, Baker TS, Reed LJ. On the unique structural organization of the Saccharomyces cerevisiae pyruvate dehydrogenase complex. J Biol Chem. 1997 Feb 28; 272(9):5757-64. view on PubMed

Zhou ZH, Hardt S, Wang B, Sherman MB, Jakana J, Chiu W. CTF determination of images of ice-embedded single particles using a graphics interface. J Struct Biol. 1996 Jan-Feb; 116(1):216-22. view on PubMed

Zhou ZH, He J, Jakana J, Tatman JD, Rixon FJ, Chiu W. Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids. Nat Struct Biol. 1995 Nov; 2(11):1026-30. view on PubMed

Zhou ZH, Prasad BV, Jakana J, Rixon FJ, Chiu W. Protein subunit structures in the herpes simplex virus A-capsid determined from 400 kV spot-scan electron cryomicroscopy. J Mol Biol. 1994 Sep 30; 242(4):456-69. view on PubMed

Zhou ZH, Chiu W. Prospects for using an IVEM with a FEG for imaging macromolecules towards atomic resolution. Ultramicroscopy. 1993 Feb; 49(1-4):407-16. view on PubMed