Amy Rowat
Publications:
Wu Y, Song Y, Soto J, Hoffman T, Lin X, Zhang A, Chen S, Massad RN, Han X, Qi D, Yeh KW, Fang Z, Eoh J, Gu L, Rowat AC, Gu Z, Li S. Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity. Nat Commun. 2025 Apr 30; 16(1):4054. view on PubMed
Wu Y, Song Y, Soto J, Hoffman T, Lin X, Zhang A, Chen S, Massad RN, Han X, Qi D, Yeh KW, Fang Z, Eoh J, Gu L, Rowat AC, Gu Z, Li S. Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity. bioRxiv. 2025 Mar 26. view on PubMed
Lan H, Tan XHM, Le MT, Chien HY, Zheng R, Rowat AC, Teitell MA, Chiou PY. Optomagnetic Micromirror Arrays for Mapping Large Area Stiffness Distributions of Biomimetic Materials. Small. 2025 Jan; 21(1):e2406389. view on PubMed
Kawecki NS, Chen KK, Smith CS, Xie Q, Cohen JM, Rowat AC. Scalable Processes for Culturing Meat Using Edible Scaffolds. Annu Rev Food Sci Technol. 2024 Jun; 15(1):241-264. view on PubMed
Hu S, Chapski DJ, Gehred ND, Kimball TH, Gromova T, Flores A, Rowat AC, Chen J, Packard RRS, Olszewski E, Davis J, Rau CD, McKinsey TA, Rosa-Garrido M, Vondriska TM. Histone H1.0 couples cellular mechanical behaviors to chromatin structure. Nat Cardiovasc Res. 2024; 3(4):441-459. view on PubMed
Bermudez A, Muñoz SN, Blaik R, Rowat AC, Hu J, Lin NYC. Using Histologic Image Analysis to Understand Biophysical Regulations of Epithelial Cell Morphology. Biophysicist (Rockv). 2024; 5(1):1-14. view on PubMed
Kawecki NS, Norris SCP, Xu Y, Wu Y, Davis AR, Fridman E, Chen KK, Crosbie RH, Garmyn AJ, Li S, Mason TG, Rowat AC. Engineering multicomponent tissue by spontaneous adhesion of myogenic and adipogenic microtissues cultured with customized scaffolds. Food Res Int. 2023 10; 172:113080. view on PubMed
Soto J, Song Y, Wu Y, Chen B, Park H, Akhtar N, Wang PY, Hoffman T, Ly C, Sia J, Wong S, Kelkhoff DO, Chu J, Poo MM, Downing TL, Rowat AC, Li S. Reduction of Intracellular Tension and Cell Adhesion Promotes Open Chromatin Structure and Enhances Cell Reprogramming. Adv Sci (Weinh). 2023 08; 10(24):e2300152. view on PubMed
Ly C, Ogana H, Kim HN, Hurwitz S, Deeds EJ, Kim YM, Rowat AC. Altered physical phenotypes of leukemia cells that survive chemotherapy treatment. Integr Biol (Camb). 2023 04 11; 15. view on PubMed
Song Y, Soto J, Chen B, Hoffman T, Zhao W, Zhu N, Peng Q, Liu L, Ly C, Wong PK, Wang Y, Rowat AC, Kurdistani SK, Li S. Transient nuclear deformation primes epigenetic state and promotes cell reprogramming. Nat Mater. 2022 10; 21(10):1191-1199. view on PubMed
Fu T, Chan TW, Bahn JH, Kim TH, Rowat AC, Xiao X. Multifaceted role of RNA editing in promoting loss-of-function of PODXL in cancer. iScience. 2022 Aug 19; 25(8):104836. view on PubMed
Norris SCP, Kawecki NS, Davis AR, Chen KK, Rowat AC. Emulsion-templated microparticles with tunable stiffness and topology: Applications as edible microcarriers for cultured meat. Biomaterials. 2022 08; 287:121669. view on PubMed
Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S. Corrigendum to "Unraveling the mechanobiology of immune cells" [Curr Opin Biotechnol 66 (2020) 236-245]. Curr Opin Biotechnol. 2022 Feb; 73:387-388. view on PubMed
Yu W, Sharma S, Rao E, Rowat AC, Gimzewski JK, Han D, Rao J. Cancer cell mechanobiology: a new frontier for cancer research. J Natl Cancer Cent. 2022 Mar; 2(1):10-17. view on PubMed
Yuen JSK, Stout AJ, Kawecki NS, Letcher SM, Theodossiou SK, Cohen JM, Barrick BM, Saad MK, Rubio NR, Pietropinto JA, DiCindio H, Zhang SW, Rowat AC, Kaplan DL. Perspectives on scaling production of adipose tissue for food applications. Biomaterials. 2022 01; 280:121273. view on PubMed
Kim PH, Chen NY, Heizer PJ, Tu Y, Weston TA, Fong JL, Gill NK, Rowat AC, Young SG, Fong LG. Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome. JCI Insight. 2021 08 23; 6(16). view on PubMed
Yu W, Lu QY, Sharma S, Ly C, Di Carlo D, Rowat AC, LeClaire M, Kim D, Chow C, Gimzewski JK, Rao J. Single Cell Mechanotype and Associated Molecular Changes in Urothelial Cell Transformation and Progression. Front Cell Dev Biol. 2020; 8:601376. view on PubMed
Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S. Unraveling the mechanobiology of immune cells. Curr Opin Biotechnol. 2020 12; 66:236-245. view on PubMed
Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020 08 06; 182(3):545-562.e23. view on PubMed
Moose DL, Krog BL, Kim TH, Zhao L, Williams-Perez S, Burke G, Rhodes L, Vanneste M, Breheny P, Milhem M, Stipp CS, Rowat AC, Henry MD. Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Cell Rep. 2020 03 17; 30(11):3864-3874.e6. view on PubMed
Lawrenson K, Fonseca MAS, Liu AY, Segato Dezem F, Lee JM, Lin X, Corona RI, Abbasi F, Vavra KC, Dinh HQ, Gill NK, Seo JH, Coetzee S, Lin YG, Pejovic T, Mhawech-Fauceglia P, Rowat AC, Drapkin R, Karlan BY, Hazelett DJ, Freedman ML, Gayther SA, Noushmehr H. A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development. Cell Rep. 2019 12 10; 29(11):3726-3735.e4. view on PubMed
Rowat AC, Soh M, Malan H, Jensen L, Schmidt L, Slusser W. Promoting an interdisciplinary food literacy framework to cultivate critical citizenship. J Am Coll Health. 2021 May-Jun; 69(4):459-462. view on PubMed
Nguyen AV, Trompetto B, Tan XHM, Scott MB, Hu KH, Deeds E, Butte MJ, Chiou PY, Rowat AC. Differential Contributions of Actin and Myosin to the Physical Phenotypes and Invasion of Pancreatic Cancer Cells. Cell Mol Bioeng. 2020 Feb; 13(1):27-44. view on PubMed
Malan H, Watson TD, Slusser W, Glik D, Rowat AC, Prelip M. Challenges, Opportunities, and Motivators for Developing and Applying Food Literacy in a University Setting: A Qualitative Study. J Acad Nutr Diet. 2020 01; 120(1):33-44. view on PubMed
Sano M, Kaji N, Rowat AC, Yasaki H, Shao L, Odaka H, Yasui T, Higashiyama T, Baba Y. Microfluidic Mechanotyping of a Single Cell with Two Consecutive Constrictions of Different Sizes and an Electrical Detection System. Anal Chem. 2019 10 15; 91(20):12890-12899. view on PubMed
Gill NK, Ly C, Kim PH, Saunders CA, Fong LG, Young SG, Luxton GWG, Rowat AC. DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces. Front Cell Dev Biol. 2019; 7:103. view on PubMed
Gunaratne PH, Pan Y, Rao AK, Lin C, Hernandez-Herrera A, Liang K, Rait AS, Venkatanarayan A, Benham AL, Rubab F, Kim SS, Rajapakshe K, Chan CK, Mangala LS, Lopez-Berestein G, Sood AK, Rowat AC, Coarfa C, Pirollo KF, Flores ER, Chang EH. Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors. Cancer. 2019 07 15; 125(14):2409-2422. view on PubMed
Gill NK, Ly C, Nyberg KD, Lee L, Qi D, Tofig B, Reis-Sobreiro M, Dorigo O, Rao J, Wiedemeyer R, Karlan B, Lawrenson K, Freeman MR, Damoiseaux R, Rowat AC. A scalable filtration method for high throughput screening based on cell deformability. Lab Chip. 2019 01 15; 19(2):343-357. view on PubMed
Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK, Rowat AC. Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function. FASEB J. 2019 03; 33(3):3997-4006. view on PubMed
Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential. Cancer Res. 2018 11 01; 78(21):6086-6097. view on PubMed
Nyberg KD, Bruce SL, Nguyen AV, Chan CK, Gill NK, Kim TH, Sloan EK, Rowat AC. Predicting cancer cell invasion by single-cell physical phenotyping. Integr Biol (Camb). 2018 04 23; 10(4):218-231. view on PubMed
Nyberg KD, Hu KH, Kleinman SH, Khismatullin DB, Butte MJ, Rowat AC. Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties. Biophys J. 2017 Oct 03; 113(7):1574-1584. view on PubMed
Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Coarfa C, Ma Y, Moore RA, Schein JE, Mungall AJ, Liu J, Pecot CV, Sood AK, Jones SJ, Marra MA, Gunaratne PH. Correction: miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget. 2017 03 07; 8(10):17406. view on PubMed
Evans AA, Cheung E, Nyberg KD, Rowat AC. Wrinkling of milk skin is mediated by evaporation. Soft Matter. 2017 Feb 07; 13(5):1056-1062. view on PubMed
Nguyen AV, Nyberg KD, Scott MB, Welsh AM, Nguyen AH, Wu N, Hohlbauch SV, Geisse NA, Gibb EA, Robertson AG, Donahue TR, Rowat AC. Stiffness of pancreatic cancer cells is associated with increased invasive potential. Integr Biol (Camb). 2016 12 05; 8(12):1232-1245. view on PubMed
Kim TH, Gill NK, Nyberg KD, Nguyen AV, Hohlbauch SV, Geisse NA, Nowell CJ, Sloan EK, Rowat AC. Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling. J Cell Sci. 2016 12 15; 129(24):4563-4575. view on PubMed
Chan CK, Pan Y, Nyberg K, Marra MA, Lim EL, Jones SJ, Maar D, Gibb EA, Gunaratne PH, Robertson AG, Rowat AC. Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour. Open Biol. 2016 11; 6(11). view on PubMed
Nyberg KD, Scott MB, Bruce SL, Gopinath AB, Bikos D, Mason TG, Kim JW, Choi HS, Rowat AC. The physical origins of transit time measurements for rapid, single cell mechanotyping. Lab Chip. 2016 08 16; 16(17):3330-9. view on PubMed
Kim TH, Rowat AC, Sloan EK. Neural regulation of cancer: from mechanobiology to inflammation. Clin Transl Immunology. 2016 May; 5(5):e78. view on PubMed
Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Coarfa C, Ma Y, Moore RA, Schein JE, Mungall AJ, Liu J, Pecot CV, Sood AK, Jones SJ, Marra MA, Gunaratne PH. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget. 2016 May 03; 7(18):25930-48. view on PubMed
Qi D, Kaur Gill N, Santiskulvong C, Sifuentes J, Dorigo O, Rao J, Taylor-Harding B, Ruprecht Wiedemeyer W, Rowat AC. Screening cell mechanotype by parallel microfiltration. Sci Rep. 2015 Dec 02; 5:17595. view on PubMed
Lautscham LA, Kämmerer C, Lange JR, Kolb T, Mark C, Schilling A, Strissel PL, Strick R, Gluth C, Rowat AC, Metzner C, Fabry B. Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness. Biophys J. 2015 Sep 01; 109(5):900-13. view on PubMed
Zhou L, Nyberg K, Rowat AC. Understanding diffusion theory and Fick's law through food and cooking. Adv Physiol Educ. 2015 Sep; 39(3):192-7. view on PubMed
Hoelzle DJ, Varghese BA, Chan CK, Rowat AC. A microfluidic technique to probe cell deformability. J Vis Exp. 2014 Sep 03; (91):e51474. view on PubMed
Clarke CF, Rowat AC, Gober JW. Osmotic stress: Is CoQ a membrane stabilizer? Nat Chem Biol. 2014 Apr; 10(4):242-3. view on PubMed
Fogle C, Rowat AC, Levine AJ, Rudnick J. Shape transitions in soft spheres regulated by elasticity. Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Nov; 88(5):052404. view on PubMed
Rowat AC, Jaalouk DE, Zwerger M, Ung WL, Eydelnant IA, Olins DE, Olins AL, Herrmann H, Weitz DA, Lammerding J. Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. J Biol Chem. 2013 Mar 22; 288(12):8610-8618. view on PubMed
Martinez CJ, Kim JW, Ye C, Ortiz I, Rowat AC, Marquez M, Weitz D. A microfluidic approach to encapsulate living cells in uniform alginate hydrogel microparticles. Macromol Biosci. 2012 Jul; 12(7):946-51. view on PubMed
Lin YC, Broedersz CP, Rowat AC, Wedig T, Herrmann H, Mackintosh FC, Weitz DA. Divalent cations crosslink vimentin intermediate filament tail domains to regulate network mechanics. J Mol Biol. 2010 Jun 18; 399(4):637-44. view on PubMed
Agresti JJ, Antipov E, Abate AR, Ahn K, Rowat AC, Baret JC, Marquez M, Klibanov AM, Griffiths AD, Weitz DA. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4004-9. view on PubMed
Rowat AC, Bird JC, Agresti JJ, Rando OJ, Weitz DA. Tracking lineages of single cells in lines using a microfluidic device. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18149-54. view on PubMed
Ebina W, Rowat AC, Weitz DA. Electrodes on a budget: Micropatterned electrode fabrication by wet chemical deposition. Biomicrofluidics. 2009 Sep 08; 3(3):34104. view on PubMed
Rafat M, Raad DR, Rowat AC, Auguste DT. Fabrication of reversibly adhesive fluidic devices using magnetism. Lab Chip. 2009 Oct 21; 9(20):3016-9. view on PubMed
Rowat AC. Physical properties of the nucleus studied by micropipette aspiration. Methods Mol Biol. 2009; 464:3-12. view on PubMed
Schmitz CH, Rowat AC, Köster S, Weitz DA. Dropspots: a picoliter array in a microfluidic device. Lab Chip. 2009 Jan 07; 9(1):44-9. view on PubMed
Holtze C, Rowat AC, Agresti JJ, Hutchison JB, Angilè FE, Schmitz CH, Köster S, Duan H, Humphry KJ, Scanga RA, Johnson JS, Pisignano D, Weitz DA. Biocompatible surfactants for water-in-fluorocarbon emulsions. Lab Chip. 2008 Oct; 8(10):1632-9. view on PubMed
Köster S, Angilè FE, Duan H, Agresti JJ, Wintner A, Schmitz C, Rowat AC, Merten CA, Pisignano D, Griffiths AD, Weitz DA. Drop-based microfluidic devices for encapsulation of single cells. Lab Chip. 2008 Jul; 8(7):1110-5. view on PubMed
Terama E, Ollila OH, Salonen E, Rowat AC, Trandum C, Westh P, Patra M, Karttunen M, Vattulainen I. Influence of ethanol on lipid membranes: from lateral pressure profiles to dynamics and partitioning. J Phys Chem B. 2008 Apr 03; 112(13):4131-9. view on PubMed
Rowat AC, Lammerding J, Herrmann H, Aebi U. Towards an integrated understanding of the structure and mechanics of the cell nucleus. Bioessays. 2008 Mar; 30(3):226-36. view on PubMed
Kasza KE, Rowat AC, Liu J, Angelini TE, Brangwynne CP, Koenderink GH, Weitz DA. The cell as a material. Curr Opin Cell Biol. 2007 Feb; 19(1):101-7. view on PubMed
Rowat AC, Lammerding J, Ipsen JH. Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J. 2006 Dec 15; 91(12):4649-64. view on PubMed
Henriksen J, Rowat AC, Brief E, Hsueh YW, Thewalt JL, Zuckermann MJ, Ipsen JH. Universal behavior of membranes with sterols. Biophys J. 2006 Mar 01; 90(5):1639-49. view on PubMed
Rowat AC, Kitson N, Thewalt JL. Interactions of oleic acid and model stratum corneum membranes as seen by 2H NMR. Int J Pharm. 2006 Jan 13; 307(2):225-31. view on PubMed
Rowat AC, Keller D, Ipsen JH. Effects of farnesol on the physical properties of DMPC membranes. Biochim Biophys Acta. 2005 Jul 15; 1713(1):29-39. view on PubMed
Rowat AC, Foster LJ, Nielsen MM, Weiss M, Ipsen JH. Characterization of the elastic properties of the nuclear envelope. J R Soc Interface. 2005 Mar 22; 2(2):63-9. view on PubMed
Henriksen J, Rowat AC, Ipsen JH. Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity. Eur Biophys J. 2004 Dec; 33(8):732-41. view on PubMed
Rowat AC, Davis JH. Farnesol-DMPC phase behaviour: a (2)H-NMR study. Biochim Biophys Acta. 2004 Mar 09; 1661(2):178-87. view on PubMed
Rowat AC, Brask J, Sparrman T, Jensen KJ, Lindblom G, Ipsen JH. Farnesylated peptides in model membranes: a biophysical investigation. Eur Biophys J. 2004 Jul; 33(4):300-9. view on PubMed
