Alexander Nguyen
Publications:
Becker AP, Biletch E, Kennelly JP, Hong SG, Julio AR, Villanueva M, Nagari RT, Turner DW, Burton NR, Fukuta T, Cui L, Xiao X, Vellani Z, Nguyen A, Mack JJ, Tontonoz P, Backus KM. Photosensitizer proximity labeling captures the lipid and protein interactomes. Nat Chem Biol. 2026 Feb 06. view on PubMed
Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen A, Srikanth S, Weston T, Uchiyama LF, Cohn W, Cho DH, Lee MS, Whitelegge J, Gwack Y, Young SG, Bensinger SJ, Tontonoz P. T cell cholesterol transport links intestinal immune responses to dietary lipid absorption. Science. 2025 Oct 09; 390(6769):eadt4169. view on PubMed
Uchiyama LF, Nguyen A, Qian K, Cui L, Pham KT, Xiao X, Gao Y, Shimanaka Y, Tol MJ, Vergnes L, Reue K, Tontonoz P. PPARα regulates ER-lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes. Proc Natl Acad Sci U S A. 2025 Apr 29; 122(17):e2426338122. view on PubMed
Uchiyama LF, Ordonez GPM, Pham KT, Kennelly JP, López Rodríguez M, Tran L, Tontonoz P, Nguyen A. PPARɑ variant V227A reduces plasma triglycerides through enhanced lipoprotein lipolysis. J Lipid Res. 2025 May; 66(5):100806. view on PubMed
Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P. Cholesterol binding to VCAM-1 promotes vascular inflammation. bioRxiv. 2024 Sep 18. view on PubMed
Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young SG, Bensinger SJ, Tontonoz P. T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption. bioRxiv. 2024 Mar 11. view on PubMed
Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023 11 10; 382(6671):eadf0966. view on PubMed
Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake. bioRxiv. 2023 Jul 10. view on PubMed
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 01; 5(1):165-181. view on PubMed
Priest C, Nagari RT, Bideyan L, Lee SD, Nguyen A, Xiao X, Tontonoz P. Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2201859119. view on PubMed
