Ambre Bertholet*

/in /by

Publications:

Shimanaka Y, Tol MJ, Rocha-Roa C, Jellinek MJ, Cui L, Bender A, Bedard AH, Milner MG, Melillo B, Shoucri BM, Wong A, Williams KJ, Stiles L, Shum M, Weston TA, Cohn W, Whitelegge JP, Budin I, Bertholet AM, Cravatt BF, Young SG, Houten SM, Argmann C, Ford DA, Liesa M, Shirihai OS, Vanni S, Tontonoz P. A cold-inducible phospholipid-protein interaction in brown fat mitochondria optimizes thermogenic capacity. bioRxiv. 2025 May 18. view on PubMed

Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 03; 300(3):105702. view on PubMed

Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. bioRxiv. 2023 Aug 16. view on PubMed

Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV. Mitochondrial uncouplers impair human sperm motility without altering ATP content†. Biol Reprod. 2023 08 10; 109(2):192-203. view on PubMed

Chang CF, Gunawan AL, Liparulo I, Zushin PH, Bertholet AM, Kirichok Y, Stahl A. CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression. Antioxidants (Basel). 2022 Dec 22; 12(1). view on PubMed

Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 2022 06; 606(7912):180-187. view on PubMed

Bertholet AM, Kirichok Y. Mitochondrial H+ Leak and Thermogenesis. Annu Rev Physiol. 2022 02 10; 84:381-407. view on PubMed

Bertholet AM. The Use of the Patch-Clamp Technique to Study the Thermogenic Capacity of Mitochondria. J Vis Exp. 2021 05 03; (171). view on PubMed

Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D. Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold. J Biol Chem. 2021 Jan-Jun; 296:100632. view on PubMed

Bertholet AM, Kirichok Y. Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat. Front Physiol. 2020; 11:326. view on PubMed

Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 2019 07; 571(7766):515-520. view on PubMed

Bertholet AM, Kirichok Y. The Mechanism FA-Dependent H+ Transport by UCP1. Handb Exp Pharmacol. 2019; 251:143-159. view on PubMed

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 12 14; 171(7):1707. view on PubMed

Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 04; 25(4):811-822.e4. view on PubMed

Bertholet AM, Kirichok Y. UCP1: A transporter for H+ and fatty acid anions. Biochimie. 2017 Mar; 134:28-34. view on PubMed

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. view on PubMed

Millet AM, Bertholet AM, Daloyau M, Reynier P, Galinier A, Devin A, Wissinguer B, Belenguer P, Davezac N. Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis. Ann Clin Transl Neurol. 2016 Jun; 3(6):408-21. view on PubMed

Bertholet AM, Millet AM, Guillermin O, Daloyau M, Davezac N, Miquel MC, Belenguer P. OPA1 loss of function affects in vitro neuronal maturation. Brain. 2013 May; 136(Pt 5):1518-33. view on PubMed

Landes T, Leroy I, Bertholet A, Diot A, Khosrobakhsh F, Daloyau M, Davezac N, Miquel MC, Courilleau D, Guillou E, Olichon A, Lenaers G, Arnauné-Pelloquin L, Emorine LJ, Belenguer P. OPA1 (dys)functions. Semin Cell Dev Biol. 2010 Aug; 21(6):593-8. view on PubMed

Betourne A, Bertholet AM, Labroue E, Halley H, Sun HS, Lorsignol A, Feng ZP, French RJ, Penicaud L, Lassalle JM, Frances B. Involvement of hippocampal CA3 K(ATP) channels in contextual memory. Neuropharmacology. 2009 Mar; 56(3):615-25. view on PubMed