Cody is studying the differences and similarities between the mechanisms underlying non-small cell and small cell cancers of the lung.
Posttranslational modification of β-catenin is associated with pathogenic fibroblastic changes in bronchopulmonary dysplasia. Sucre JM, Vijayaraj P, Aros CJ, Wilkinson D, Paul M, Dunn B, Guttentag SH, Gomperts BN. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L186-L195. doi: 10.1152/ajplung.00477.2016. Epub 2016 Dec 9.
In the Coller Lab we are interested in quiescence, the cells resting state outside it’s proliferation cycle. Adriana is interested in the epigenetic changes that occur as a cell transitions from quiescence to proliferation (and vice versa) and how these epigenetic changes affect proliferation, gene expression, and chromatin compaction.
Samantha is studying how the chromatin environment affects pre-mRNA splicing.
Posttranscriptional Regulation of Gcr1 Expression and Activity Is Crucial for Metabolic Adjustment in Response to Glucose Availability. Hossain MA, Claggett JM, Edwards SR, Shi A, Pennebaker SL, Cheng MY, Hasty J, Johnson TL. Mol Cell. 2016 May 5;62(3):346-58. doi: 10.1016/j.molcel.2016.04.012.
Transcriptional activation of early viral genes by adenovirus large E1A via interactions with Mediator and p300
Michael studies how transcription factor binding events at enhancers interact to stimulate enhancer-promoter looping and subsequent gene expression.
Jarrett is studying super enhancer logic in mouse embryonic stem cells.
Shawntel studies the enzymatic activity underlying RNAPII CTD modification and its relationship to the splicing machinery.
Alex Salisbury (David)
Shawn (Ying Xuan) Tan
Shawn is working on elucidation of the localization and molecular function of the Tsix IncRNA.
Guillaume researches multiplexed library approaches to studying promoter architecture in E. coli.
Characterizing the mechanisms of adenoviral E1A cellular reprogramming by examining its influence on gene expression and interacting cellular proteins.
Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection. Ferrari R, Gou D, Jawdekar G, Johnson SA, Nava M, Su T, Yousef AF, Zemke NR, Pellegrini M, Kurdistani SK, Berk AJ. Cell Host Microbe. 2014 Nov 12;16(5):663-76. doi: 10.1016/j.chom.2014.10.004. Epub 2014 Nov 12.