Gene Regulation Current Students

Cody Aros

Mentor: Brigitte Gomperts
Research project:

Cody is studying the differences and similarities between the mechanisms underlying non-small cell and small cell cancers of the lung.

Publications:

Posttranslational modification of β-catenin is associated with pathogenic fibroblastic changes in bronchopulmonary dysplasia. Sucre JM, Vijayaraj P, Aros CJ, Wilkinson D, Paul M, Dunn B, Guttentag SH, Gomperts BN. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L186-L195. doi: 10.1152/ajplung.00477.2016. Epub 2016 Dec 9.

Narsis Attar

Mentor: Siavash Kurdistani
Research project:

Narsis’ current research involves investigating a novel function of chromatin in regulating cellular metal homeostasis.

Publications:

Narsis Attar & Siavash Kurdistani. Layered regulation of the epigenome and its link to cellular metabolism and physiology. Am. Assoc. Cancer Res. Educ. Book, April 2014

Endoplasmic reticulum-mitochondria junction is required for iron homeostasis. Xue Y, Schmollinger S, Attar N, Campos O, Vogelauer M, Carey MF, Merchant SS, Kurdistani SK. J Biol Chem. 2017 Jun 21. pii: jbc.M117.784249. doi: 10.1074/jbc.M117.784249. [Epub ahead of print]

Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts. Nguyen AH, Elliott IA, Wu N, Matsumura C, Vogelauer M, Attar N, Dann A, Ghukasyan R, Toste PA, Patel SG, Williams JL, Li L, Dawson DW, Radu C, Kurdistani SK, Donahue TR. Oncotarget. 2017 Mar 21;8(12):19074-19088. doi: 10.18632/oncotarget.13572.

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer. Attar N, Kurdistani SK. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3). pii: a026534. doi: 10.1101/cshperspect.a026534. Review.

Oscar Campos

Mentor: Siavash Kurdistani
Research project:

Oscar’s current research involves identifying the mechanisms and functions of genome compaction, with particular emphasis on the role of histones.

Publications:

Endoplasmic reticulum-mitochondria junction is required for iron homeostasis. Xue Y, Schmollinger S, Attar N, Campos O, Vogelauer M, Carey MF, Merchant SS, Kurdistani SK. J Biol Chem. 2017 Jun 21. pii: jbc.M117.784249. doi: 10.1074/jbc.M117.784249. [Epub ahead of print]

Evolution of histone 2A for chromatin compaction in eukaryotes. Macadangdang BR, Oberai A, Spektor T, Campos OA, Sheng F, Carey MF, Vogelauer M, Kurdistani SK. Elife. 2014 Jun 17;3. doi: 10.7554/eLife.02792.

Adriana Corvalan

Mentor: Hillary Coller
Research project:

In the Coller Lab we are interested in quiescence, the cells resting state outside it’s proliferation cycle. Adriana is interested in the epigenetic changes that occur as a cell transitions from quiescence to proliferation (and vice versa) and how these epigenetic changes affect proliferation, gene expression, and chromatin compaction.

Nivedita Damodaren

Mentor: Currently rotating

Samantha Edwards

Mentor: Tracy Johnson
Research project:

Samantha is studying how the chromatin environment affects pre-mRNA splicing.

Publications:

Posttranscriptional Regulation of Gcr1 Expression and Activity Is Crucial for Metabolic Adjustment in Response to Glucose Availability. Hossain MA, Claggett JM, Edwards SR, Shi A, Pennebaker SL, Cheng MY, Hasty J, Johnson TL. Mol Cell. 2016 May 5;62(3):346-58. doi: 10.1016/j.molcel.2016.04.012.

Emily Hsu

Mentor: Arnold Berk

Research project:

Transcriptional activation of early viral genes by adenovirus large E1A via interactions with Mediator and p300

Lucia Ichino

Mentor: Currently rotating

Andrew King

Mentor: Guoping Fan
Research project:

Andrew is studying prostate cancer and prostate stem cells’ role in tumorigenesis.

Michael Kronenberg

Mentor: Michael Carey

Research Project:

Michael studies how transcription factor binding events at enhancers interact to stimulate enhancer-promoter looping and subsequent gene expression.

Jarrett Miller

Mentor: Kathrin Plath

Research project:

Jarrett is studying super enhancer logic in mouse embryonic stem cells.

Lauren Neves

Mentor: Tracy Johnson
Research project:

Lauren studies the role of histone variant H2A.Z in co-transcriptional mRNA splicing

Publications:

The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae. Neves LT, Douglass S, Spreafico R, Venkataramanan S, Kress TL, Johnson TL. Genes Dev. 2017 Apr 1;31(7):702-717. doi: 10.1101/gad.295188.116.

Shawntel Okonkwo

Mentor: Tracy Johnson
Research project:

Shawntel studies the enzymatic activity underlying RNAPII CTD modification and its relationship to the splicing machinery.

Katherine Pohl

Mentor: Currently rotating

Kevin Qian

Mentor: Peter Tontonoz

Graham Read

Mentor: Currently rotating

Alex Salisbury (David)

Mentor: Tamer Sallam and Peter Tontonoz

Jaspreet Sandhu

Mentor: Peter Tontonoz
 Research project:

Jaspreet’s research focuses on Nuclear Receptors in Metabolism.

Publications:

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2. Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. Cell Rep. 2016 Nov 1;17(6):1671-1682. doi: 10.1016/j.celrep.2016.10.023.

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. Nature. 2016 May 11;534(7605):124-8. doi: 10.1038/nature17674.

Carina Sandoval

Mentor: Currently rotating

Shoghig Haverj Stanboulian

Mentor: Currently rotating

Shawn (Ying Xuan) Tan

Mentor: Kathrin Plath
Research project:

Shawn is working on elucidation of the localization and molecular function of the Tsix IncRNA.

Guillaume Urtecho

Mentor: Sri Kosuri

Research project:

Guillaume researches multiplexed library approaches to studying promoter architecture in E. coli.

Celine Vuong

Mentor: Douglas Black
Research project:

Celine’s current research focuses on the role of splicing regulation in the control of neuronal activity.

Publications:

The neurogenetics of alternative splicing. Vuong CK, Black DL, Zheng S. Nat Rev Neurosci. 2016 Apr 20;17(5):265-81. doi: 10.1038/nrn.2016.27.

Nathan Zemke

Mentor: Arnold Berk
Research project:

Characterizing the mechanisms of adenoviral E1A cellular reprogramming by examining its influence on gene expression and interacting cellular proteins.

Publications:

Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection. Ferrari R, Gou D, Jawdekar G, Johnson SA, Nava M, Su T, Yousef AF, Zemke NR, Pellegrini M, Kurdistani SK, Berk AJ. Cell Host Microbe. 2014 Nov 12;16(5):663-76. doi: 10.1016/j.chom.2014.10.004. Epub 2014 Nov 12.

Lingyu Zhan

Mentor: Jae Hoon Sul
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