Theodoros Kelesidis
/in /by SOFIA
Email Address:
tkelesidis@mednet.ucla.edu
Office Phone Number:
(310) 7875
Website
Sagasti Lab
Office Address:
CHS 47-200
The primary research interests of the Kelesidis Lab focus on basic and translational research platforms
uncovering the molecular host mechanisms driving immunopathogenesis of viral infections such as HIV
infection and SARS-CoV-2. Our laboratory is actively identifying and validating unique molecular signatures
that characterize the complex cross talk between infection with viruses such as HIV and SARS-COV-2,
oxidative stress, inflammation and end organ disease such as cardiovascular disease.
We use ex vivo/in vitro approaches with human cells from HIV-1 infected and uninfected persons and a
humanized mouse model to determine mechanisms of HIV-associated immune dysfunction, end organ disease
and novel therapeutics. We also use cell culture and mouse models of SARS-CoV-2 infection to determine
mechanisms of SARS-CoV-2 replication and associated tissue damage with a goal to develop novel
therapeutics.
A selected list of publications:
Adipokines, Weight Gain and Metabolic and Inflammatory Markers After Antiretroviral Therapy Initiation: AIDS Clinical Trials Group (ACTG) A5260s. Clin Infect Dis. 2022 03 09; 74(5):857-864. Koethe JR, Moser C, Brown TT, Stein JH, Kelesidis T, Dube M, Currier J, McComsey GA, Kelesidis T, Currier J. PMID: 34117756; PMCID: PMC8906713.
Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways. bioRxiv. 2022 Feb 24. Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. PMID: 35233569; PMCID: PMC8887067.
Instigators of COVID-19 in Immune Cells Are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared With Nonsmokers. Nicotine Tob Res. 2022 02 14; 24(3):413-415. Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR, Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR. PMID: 34410424; PMCID: PMC8513409.
Race and sex differences in HDL peroxide content among American adults with and without type 2 diabetes. Lipids Health Dis. 2022 Feb 06; 21(1):18. Flaherty SM, Wood EK, Ryff CD, Love GD, Kelesidis T, Berkowitz L, Echeverría G, Rivera K, Rigotti A, Coe CL. PMID: 35125112; PMCID: PMC8818198.
ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV. PLoS Pathog. 2022 01; 18(1):e1010160. Daskou M, Mu W, Sharma M, Vasilopoulos H, Heymans R, Ritou E, Rezek V, Hamid P, Kossyvakis A, Sen Roy S, Grijalva V, Chattopadhyay A, Kitchen SG, Fogelman AM, Reddy ST, Kelesidis T. PMID: 34995311; PMCID: PMC8740974.
The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227. Kelesidis T, Madhav S, Petcherski A, Cristelle H, O’Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. PMID: 34494942; PMCID: PMC8437485.
Association of 1 Vaping Session With Cellular Oxidative Stress in Otherwise Healthy Young People With No History of Smoking or Vaping: A Randomized Clinical Crossover Trial. JAMA Pediatr. 2021 11 01; 175(11):1174-1176. Kelesidis T, Tran E, Nguyen R, Zhang Y, Sosa G, Middlekauff HR. PMID: 34369981; PMCID: PMC8353577.
Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study. AIDS Res Hum Retroviruses. 2021 11; 37(11):842-845. Sarkar S, Haberlen S, Post W, Kelesidis T, Wiley D, Kingsley L, Kim EY, Palella FJ, Witt MD, Budoff M, Rodriguez A, Brown TT, Sarkar S, Haberlen S, Post WS, Kelesidis T, Wiley D, Kingsley L, Kim EY, Palella FJ, Witt MD, Budoff MJ, Rodriguez A, Brown TT. PMID: 34384260; PMCID: PMC8817687.
ApoA-I mimetics favorably impact cyclooxygenase 2 and bioactive lipids that may contribute to cardiometabolic syndrome in chronic treated HIV. Metabolism. 2021 11; 124:154888. Daskou M, Sharma M, Mu W, Heymans R, Ritou E, Rezek V, Hamid P, Kossyvakis A, Sen Roy S, Grijalva V, Chattopadhyay A, Papesh J, Meriwether D, Kitchen SG, Fogelman AM, Reddy ST, Kelesidis T. PMID: 34509494; PMCID: PMC8802211.
Advanced Glycation End Products Associated With Cardiometabolic Biomarkers in Treated Human Immunodeficiency Virus Infection. Open Forum Infect Dis. 2021 Oct; 8(10):ofab423. El Kamari V, Rodriguez K, Moser C, Currier JS, Kelesidis T, Stein JH, Brown TT, Howell SK, Beisswenger PJ, McComsey GA. PMID: 34631914; PMCID: PMC8496763.
Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers. Circ Res. 2021 08 20; 129(5):514-526. Gupta R, Lin Y, Luna K, Logue A, Yoon AJ, Haptonstall KP, Moheimani R, Choroomi Y, Nguyen K, Tran E, Zhu Y, Faull KF, Kelesidis T, Gornbein J, Middlekauff HR, Araujo JA. PMID: 34187173; PMCID: PMC8376792.
Increased Expression of Proatherogenic Proteins in Immune Cell Subtypes in Tobacco Cigarette Smokers But Not in Electronic Cigarette Vapers. Can J Cardiol. 2021 08; 37(8):1175-1180. Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR. PMID: 34023441.
Apolipoprotein A-I mimetics attenuate macrophage activation in chronic treated HIV. AIDS. 2021 03 15; 35(4):543-553. Mu W, Sharma M, Heymans R, Ritou E, Rezek V, Hamid P, Kossyvakis A, Sen Roy S, Grijalva V, Chattopadhyay A, Papesh J, Meriwether D, Kitchen SG, Fogelman AM, Reddy ST, Kelesidis T. PMID: 33306550; PMCID: PMC8010648.
Update in Viral Infections in the Intensive Care Unit. Front Med (Lausanne). 2021; 8:575580. Fragkou PC, Moschopoulos CD, Karofylakis E, Kelesidis T, Tsiodras S. PMID: 33708775; PMCID: PMC7940368.
Expression of Key Inflammatory Proteins Is Increased in Immune Cells From Tobacco Cigarette Smokers But Not Electronic Cigarette Vapers: Implications for Atherosclerosis. J Am Heart Assoc. 2021 01 05; 10(1):e019324. Kelesidis T, Zhang Y, Tran E, Sosa G, Middlekauff HR. PMID: 33356378; PMCID: PMC7955503.
Elevated Cellular Oxidative Stress in Circulating Immune Cells in Otherwise Healthy Young People Who Use Electronic Cigarettes in a Cross-Sectional Single-Center Study: Implications for Future Cardiovascular Risk. J Am Heart Assoc. 2020 09 15; 9(18):e016983. Kelesidis T, Tran E, Arastoo S, Lakhani K, Heymans R, Gornbein J, Middlekauff HR. PMID: 32896211; PMCID: PMC7726977.
Sudden Cardiac Arrest in a Patient With Myxedema Coma and COVID-19. J Endocr Soc. 2020 Oct 01; 4(10):bvaa130. Dixit NM, Truong KP, Rabadia SV, Li D, Srivastava PK, Mosaferi T, Calfon Press MA, Donangelo I, Kelesidis T. PMID: 32984743; PMCID: PMC7499619.
Erratum to: Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir. J Infect Dis. 2020 06 11; 221(12):2083-2084. Brown TT, Moser C, Currier JS, Ribaudo HJ, Rothenberg J, Kelesidis T, Yang O, Dubé MP, Murphy RL, Stein JH, McComsey GA. PMID: 32022230; PMCID: PMC7457181.
Neisseria gonorrhoeae as a Rare Cause of Preseptal Cellulitis. Sex Transm Dis. 2019 12; 46(12):813-815. Adamson PC, Judson SD, Klausner JD, Kelesidis T. PMID: 31356532; PMCID: PMC8077177.
Greater IL-6, D-dimer, and ICAM-1 Levels Are Associated With Lower Small HDL Particle Concentration in the Multicenter AIDS Cohort Study. Open Forum Infect Dis. 2019 Dec; 6(12):ofz474. Sarkar S, Haberlen S, Whelton S, E Schneider E, Kingsley L, Palella F, Witt MD, Kelesidis T, Rodriguez A, Post WS, Brown TT. PMID: 32128324; PMCID: PMC7047959.
A Flow Cytometric Method to Determine Transfection Efficiency. Bio Protoc. 2019 May 20; 9(10). Mu W, Homann S, Hofmann C, Gorin A, Huynh D, Yang OO, Kelesidis T. PMID: 32855997; PMCID: PMC7449265.
The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension. Eur J Prev Cardiol. 2019 08; 26(12):1301-1309. Pagonas N, Vlatsas S, Bauer F, Seibert FS, Sasko B, Buschmann I, Ritter O, Kelesidis T, Westhoff TH. PMID: 31067131; PMCID: PMC6625884.
Lorcaserin treatment decreases body weight and reduces cardiometabolic risk factors in obese adults: A six-month, randomized, placebo-controlled, double-blind clinical trial. Diabetes Obes Metab. 2019 06; 21(6):1487-1492. Tuccinardi D, Farr OM, Upadhyay J, Oussaada SM, Mathew H, Paschou SA, Perakakis N, Koniaris A, Kelesidis T, Mantzoros CS. PMID: 30724455; PMCID: PMC6504613.
High-density lipoprotein lipid peroxidation as a molecular signature of the risk for developing cardiovascular disease: Results from MASHAD cohort. J Cell Physiol. 2019 Feb 19. Samadi S, Mehramiz M, Kelesidis T, Mobarhan MG, Sahebkar AH, Esmaily H, Moohebati M, Farjami Z, Ferns GA, Mohammadpour AH, Avan A. PMID: 30784041; PMCID: PMC6699926.
Human T lymphotropic virus type 1 and risk of cardiovascular disease: High-density lipoprotein dysfunction versus serum HDL-C concentrations. Biofactors. 2019 May; 45(3):374-380. Samadi S, Abolbashari S, Meshkat Z, Mohammadpour AH, Kelesidis T, Gholoobi A, Mehramiz M, Tabadkani M, Sadabadi F, Dalirfardouei R, Ferns GA, Ghayour-Mobarhan M, Avan A. PMID: 30693992; PMCID: PMC6548577.
The Role of Lipoproteins in Mycoplasma-Mediated Immunomodulation. Front Microbiol. 2018; 9:1682. Christodoulides A, Gupta N, Yacoubian V, Maithel N, Parker J, Kelesidis T. PMID: 30108558; PMCID: PMC6080569. View in: PubMed
Brief Report: Changes in Plasma RANKL-Osteoprotegerin in a Prospective, Randomized Clinical Trial of Initial Antiviral Therapy: A5260s. J Acquir Immune Defic Syndr. 2018 07 01; 78(3):362-366. Kelesidis T, Moser CB, Johnston E, Stein JH, Dube MP, Yang OO, McComsey GA, Currier JS, Brown TT. PMID: 29533303; PMCID: PMC5997510. View in: PubMed
Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. Medicine (Baltimore). 2018 Jun; 97(22):e10955. Kelesidis T, Kendall MA, Danoff A, Aberg JA, Currier JS, Schmidt AM. PMID: 29851842; PMCID: PMC6392937. View in: PubMed
