Samantha Butler* – Molecular Biology Institute

Samantha Butler, Ph.D., previously held the Eleanor Leslie Chair in Pioneering Brain Research (7/1/2018 - 6/30/2023).

Publications:

Gupta S, Heinrichs E, Novitch BG, Butler SJ. Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses. Development. 2024 May 15; 151(10). view on PubMed

Alvarez S, Gupta S, Honeychurch K, Mercado-Ayon Y, Kawaguchi R, Butler SJ. Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling. bioRxiv. 2023 Nov 04. view on PubMed

Gupta S, Kawaguchi R, Heinrichs E, Gallardo S, Castellanos S, Mandric I, Novitch BG, Butler SJ. In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion. Cell Rep. 2022 07 19; 40(3):111119. view on PubMed

Butler SJ. The confidence to question. Science. 2021 Oct 08; 374(6564):230. view on PubMed

Gupta S, Butler SJ. Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord. WIREs Mech Dis. 2021 09; 13(5):e1520. view on PubMed

Gupta S, Yamauchi K, Novitch BG, Butler SJ. Derivation of dorsal spinal sensory interneurons from human pluripotent stem cells. STAR Protoc. 2021 03 19; 2(1):100319. view on PubMed

Alvarez S, Varadarajan SG, Butler SJ. Dorsal commissural axon guidance in the developing spinal cord. Curr Top Dev Biol. 2021; 142:197-231. view on PubMed

Vonica A, Bhat N, Phan K, Guo J, Iancu L, Weber JA, Karger A, Cain JW, Wang ECE, DeStefano GM, O'Donnell-Luria AH, Christiano AM, Riley B, Butler SJ, Luria V. Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin. Dev Biol. 2020 08 01; 464(1):71-87. view on PubMed

Frendo ME, da Silva A, Phan KD, Riche S, Butler SJ. The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons. J Neurosci. 2019 11 20; 39(47):9316-9327. view on PubMed

Lisanti AJ, Vittner D, Medoff-Cooper B, Fogel J, Wernovsky G, Butler S. Individualized Family-Centered Developmental Care: An Essential Model to Address the Unique Needs of Infants With Congenital Heart Disease. J Cardiovasc Nurs. 2019 Jan/Feb; 34(1):85-93. view on PubMed

Andrews MG, Kong J, Novitch BG, Butler SJ. New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord. Curr Top Dev Biol. 2019; 132:417-450. view on PubMed

Gupta S, Sivalingam D, Hain S, Makkar C, Sosa E, Clark A, Butler SJ. Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells. Stem Cell Reports. 2018 02 13; 10(2):390-405. view on PubMed

Andrews MG, Del Castillo LM, Ochoa-Bolton E, Yamauchi K, Smogorzewski J, Butler SJ. BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities. Elife. 2017 09 19; 6. view on PubMed

Varadarajan SG, Butler SJ. Netrin1 establishes multiple boundaries for axon growth in the developing spinal cord. Dev Biol. 2017 10 01; 430(1):177-187. view on PubMed

Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ. Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron. 2017 May 17; 94(4):790-799.e3. view on PubMed

Pearson CA, Butler SJ, Novitch BG. Neuronal organization: unsticking the cadherin code. Curr Biol. 2014 Dec 01; 24(23):R1127-9. view on PubMed

Butler SJ, Bronner ME. From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate. Dev Biol. 2015 Feb 15; 398(2):135-46. view on PubMed

Kandyba E, Hazen VM, Kobielak A, Butler SJ, Kobielak K. Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state. Stem Cells. 2014 Feb; 32(2):534-47. view on PubMed

Gaber ZB, Butler SJ, Novitch BG. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013 Oct; 11(10):e1001676. view on PubMed

Kong JH, Butler SJ, Novitch BG. My brain told me to do it. Dev Cell. 2013 Jun 10; 25(5):436-8. view on PubMed

Phan KD, Butler SJ. Bilaterally symmetric populations of chicken dI1 (commissural) axons cross the floor plate independently of each other. PLoS One. 2013; 8(4):e62977. view on PubMed

Yamauchi K, Varadarajan SG, Li JE, Butler SJ. Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity. Development. 2013 Jan 15; 140(2):333-42. view on PubMed

Phan KD, Croteau LP, Kam JW, Kania A, Cloutier JF, Butler SJ. Neogenin may functionally substitute for Dcc in chicken. PLoS One. 2011; 6(7):e22072. view on PubMed

Phan KD, Hazen VM, Frendo M, Jia Z, Butler SJ. The bone morphogenetic protein roof plate chemorepellent regulates the rate of commissural axonal growth. J Neurosci. 2010 Nov 17; 30(46):15430-40. view on PubMed

Hazen VM, Phan K, Yamauchi K, Butler SJ. Assaying the ability of diffusible signaling molecules to reorient embryonic spinal commissural axons. J Vis Exp. 2010 Mar 08; (37). view on PubMed

Novitch BG, Butler SJ. Reducing the mystery of neuronal differentiation. Cell. 2009 Sep 18; 138(6):1062-4. view on PubMed

Yamauchi K, Phan KD, Butler SJ. BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions. Development. 2008 Mar; 135(6):1119-28. view on PubMed

Butler SJ, Tear G. Getting axons onto the right path: the role of transcription factors in axon guidance. Development. 2007 Feb; 134(3):439-48. view on PubMed

Butler SJ, Dodd J. A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron. 2003 May 08; 38(3):389-401. view on PubMed

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