René Packard*
Publications:
Packard RRS. The clinical promise of 18F-flurpiridaz PET imaging heralds a new frontier in the diagnosis and management of coronary artery disease. Nat Cardiovasc Res. 2025 Jan; 4(1):1-4. view on PubMed
Packard RRS. Expanding the repertoire of 18F-labeled PET MPI radiotracers. J Nucl Cardiol. 2024 Apr; 34:101834. view on PubMed
Packard RRS, Votaw JR, Cooke CD, Van Train KF, Garcia EV, Maddahi J. 18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease categorization. Eur Heart J Cardiovasc Imaging. 2022 11 17; 23(12):1636-1644. view on PubMed
Packard RRS. Cardiac fibrosis in oncologic therapies. Curr Opin Physiol. 2022 Oct; 29. view on PubMed
Jong J, Pinney JR, Packard RRS. Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging. Front Cardiovasc Med. 2022; 9:919719. view on PubMed
Chen J, Zhu AJ, Packard RRS, Vondriska TM, Chapski DJ. genomeSidekick: A user-friendly epigenomics data analysis tool. Front Bioinform. 2022; 2:831025. view on PubMed
Abiri P, Luo Y, Huang ZY, Cui Q, Duarte-Vogel S, Roustaei M, Chang CC, Xiao X, Packard R, Cavallero S, Ebrahimi R, Benharash P, Chen J, Tai YC, Hsiai TK. 3-Dimensional electrical impedance spectroscopy for in situ endoluminal mapping of metabolically active plaques. Sens Actuators B Chem. 2022 Mar 01; 354. view on PubMed
Ding Y, Gudapati V, Lin R, Fei Y, Packard RRS, Song S, Chang CC, Baek KI, Wang Z, Roustaei M, Kuang D, Kuo CJ, Hsiai TK. Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation. IEEE Trans Biomed Eng. 2021 01; 68(1):225-235. view on PubMed
Packard RRS, Lazewatsky JL, Orlandi C, Maddahi J. Diagnostic Performance of PET Versus SPECT Myocardial Perfusion Imaging in Patients with Smaller Left Ventricles: A Substudy of the 18F-Flurpiridaz Phase III Clinical Trial. J Nucl Med. 2021 06 01; 62(6):849-854. view on PubMed
Packard RRS, Cooke CD, Van Train KF, Votaw JR, Sayre JW, Lazewatsky JL, Champagne KM, Orlandi C, Garcia EV, Maddahi J. Development, diagnostic performance, and interobserver agreement of a 18F-flurpiridaz PET automated perfusion quantitation system. J Nucl Cardiol. 2022 04; 29(2):698-708. view on PubMed
Jong J, Packard RRS. 18F-FDG PET imaging of myocardial inflammation and viability following experimental infarction and anti-inflammatory treatment with compound MCC950. J Nucl Cardiol. 2021 10; 28(5):2358-2360. view on PubMed
Khan MO, Tran JS, Zhu H, Boyd J, Packard RRS, Karlsberg RP, Kahn AM, Marsden AL. Low Wall Shear Stress Is Associated with Saphenous Vein Graft Stenosis in Patients with Coronary Artery Bypass Grafting. J Cardiovasc Transl Res. 2021 08; 14(4):770-781. view on PubMed
Chen J, Packard RRS. Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish. J Vis Exp. 2020 02 06; (156). view on PubMed
Votaw JR, Packard RRS. Motion correction to enhance absolute myocardial blood flow quantitation by PET. J Nucl Cardiol. 2020 08; 27(4):1114-1117. view on PubMed
Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Dis Model Mech. 2019 10 01; 12(10). view on PubMed
Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI Insight. 2019 04 18; 4(8). view on PubMed
Tuzovic M, Yang EH, Sevag Packard RR, Ganz PA, Fonarow GC, Ziaeian B. National Outcomes in Hospitalized Patients With Cancer and Comorbid Heart Failure. J Card Fail. 2019 Jul; 25(7):516-521. view on PubMed
Packard RRS. Dipyridamole infusion protocols for absolute myocardial blood flow quantitation by PET. J Nucl Cardiol. 2020 10; 27(5):1829-1831. view on PubMed
Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2016-2027. view on PubMed
Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). view on PubMed
Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach. Ann Biomed Eng. 2018 Dec; 46(12):2177-2188. view on PubMed
Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13). view on PubMed
Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging. Prog Biophys Mol Biol. 2018 10; 138:105-115. view on PubMed
Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 03 24; 20(5):35. view on PubMed
Luo Y, Abiri P, Zhang S, Chang CC, Kaboodrangi AH, Li R, Sahib AK, Bui A, Kumar R, Woo M, Li Z, Packard RRS, Tai YC, Hsiai TK. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content. Theranostics. 2018; 8(6):1636-1647. view on PubMed
Packard RRS, Maddahi J. Assessment of left ventricular mass by SPECT MPI. J Nucl Cardiol. 2019 06; 26(3):906-908. view on PubMed
Baek KI, Packard RRS, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal. 2018 05 01; 28(13):1209-1223. view on PubMed
Ding Y, Abiri A, Abiri P, Li S, Chang CC, Baek KI, Hsu JJ, Sideris E, Li Y, Lee J, Segura T, Nguyen TP, Bui A, Sevag Packard RR, Fei P, Hsiai TK. Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics. JCI Insight. 2017 11 16; 2(22). view on PubMed
Votaw JR, Packard RRS. Technical aspects of acquiring and measuring myocardial blood flow: Method, technique, and QA. J Nucl Cardiol. 2018 04; 25(2):665-670. view on PubMed
Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 08 17; 7(1):8603. view on PubMed
Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system. Sci Rep. 2017 07 21; 7(1):6180. view on PubMed
Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics. 2017; 7(9):2431-2442. view on PubMed
Maddahi J, Packard RRS. PET should replace SPECT in cardiac imaging for diagnosis and risk assessment of patients with known or suspected CAD: Pro. J Nucl Cardiol. 2017 12; 24(6):1955-1959. view on PubMed
Packard RRS, Maddahi J. Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation by 13N-ammonia PET and detection of cardiac allograft vasculopathy. J Nucl Cardiol. 2017 08; 24(4):1145-1148. view on PubMed
Sevag Packard RR, Karlsberg RP. Integrating FFRCT Into Routine Clinical Practice: A Solid PLATFORM or Slippery Slope? J Am Coll Cardiol. 2016 08 02; 68(5):446-449. view on PubMed
Lee J, Fei P, Sevag Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 08 01; 126(8):3158. view on PubMed
Packard RR, Li D, Budoff MJ, Karlsberg RP. Fractional flow reserve by computerized tomography and subsequent coronary revascularization. Eur Heart J Cardiovasc Imaging. 2017 Feb; 18(2):145-152. view on PubMed
Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques. Sens Actuators B Chem. 2016 Nov 01; 235:154-161. view on PubMed
Lee J, Fei P, Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 05 02; 126(5):1679-90. view on PubMed
Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Sci Rep. 2016 Mar 03; 6:22489. view on PubMed
Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 09; 44(9):2695-706. view on PubMed
Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2015 Dec; 11(12):e1005711. view on PubMed
Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics. Curr Opin Lipidol. 2015 Oct; 26(5):376-83. view on PubMed
Maddahi J, Packard RR. Cardiac PET perfusion tracers: current status and future directions. Semin Nucl Med. 2014 Sep; 44(5):333-43. view on PubMed
Packard RR, Huang SC, Dahlbom M, Czernin J, Maddahi J. Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET. J Nucl Med. 2014 Sep; 55(9):1438-44. view on PubMed
Bhutani S, Tobis J, Gevorgyan R, Sinha A, Suh W, Honda HM, Vorobiof G, Packard RR, Steadman R, Wray C, Busuttil R, Tseng CH. Accuracy of stress myocardial perfusion imaging to diagnose coronary artery disease in end stage liver disease patients. Am J Cardiol. 2013 Apr 01; 111(7):1057-61. view on PubMed
Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI. Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 2009 Aug 04; 120(5):427-36. view on PubMed
Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem. 2009 Sep 11; 284(37):24914-24. view on PubMed
Packard RR, Lichtman AH, Libby P. Innate and adaptive immunity in atherosclerosis. Semin Immunopathol. 2009 Jun; 31(1):5-22. view on PubMed
Smadja DM, Godier A, Susen S, Packard RR, Fabiani JN, Aiach M, Gaussem P. Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery. Thromb Haemost. 2009 May; 101(5):983-5. view on PubMed
Packard RR, Maganto-García E, Gotsman I, Tabas I, Libby P, Lichtman AH. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res. 2008 Oct 24; 103(9):965-73. view on PubMed
Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008 Jan; 54(1):24-38. view on PubMed
Packard RR, Schlegel S, Senouf D, Burger F, Sigaud P, Perneger T, Siegrist CA, Mach F. Atorvastatin treatment and vaccination efficacy. J Clin Pharmacol. 2007 Aug; 47(8):1022-7. view on PubMed
Packard RR, Shi GP. Atherosclerosis progression and monocyte emigration from plaque. Future Cardiol. 2006 Jul; 2(4):415-8. view on PubMed
