Leonid Kruglyak*

Leonid Kruglyak, Ph.D., holds The Diller-von Furstenberg Family Endowed Chair in Human Genetics.

Publications:

Boocock J, Alexander N, Tapia LA, Walter-McNeill L, Munugala C, Bloom JS, Kruglyak L. Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction. bioRxiv. 2023 Dec 21. view on PubMed

Guo L, Kruglyak L. Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos. Physiol Genomics. 2023 11 01; 55(11):479-486. view on PubMed

Kruglyak L, Beyer A, Bloom JS, Grossbach J, Lieberman TD, Mancuso CP, Rich MS, Sherlock G, Kaplan CD. Insufficient evidence for non-neutrality of synonymous mutations. Nature. 2023 04; 616(7957):E8-E9. view on PubMed

Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. Heritable Cas9-induced nonhomologous recombination in C. elegans. MicroPubl Biol. 2023; 2023. view on PubMed

Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. Cas9-induced nonhomologous recombination in C. elegans. bioRxiv. 2023 Jan 20. view on PubMed

Swichkow CR, Bloom JS, Kruglyak L. Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications. PLoS Biol. 2022 Dec; 20(12):e3001911. view on PubMed

Dhindsa RS, Wang Q, Vitsios D, Burren OS, Hu F, DiCarlo JE, Kruglyak L, MacArthur DG, Hurles ME, Petrovski S. A minimal role for synonymous variation in human disease. Am J Hum Genet. 2022 12 01; 109(12):2105-2109. view on PubMed

Schubert OT, Bloom JS, Sadhu MJ, Kruglyak L. Genome-wide base editor screen identifies regulators of protein abundance in yeast. Elife. 2022 Nov 03; 11. view on PubMed

Brandenberg OF, Schubert OT, Kruglyak L. Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression. Microb Cell Fact. 2022 Jun 18; 21(1):119. view on PubMed

Guo L, Bloom JS, Dols-Serrate D, Boocock J, Ben-David E, Schubert OT, Kozuma K, Ho K, Warda E, Chui C, Wei Y, Leighton D, Lemus Vergara T, Riutort M, Sánchez Alvarado A, Kruglyak L. Island-specific evolution of a sex-primed autosome in a sexual planarian. Nature. 2022 06; 606(7913):329-334. view on PubMed

Guo L, Boocock J, Hilt EE, Chandrasekaran S, Zhang Y, Munugala C, Sathe L, Alexander N, Arboleda VA, Flint J, Eskin E, Luo C, Yang S, Garner OB, Yin Y, Bloom JS, Kruglyak L. Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA. BMC Genomics. 2022 Apr 04; 23(1):260. view on PubMed

Hilt EE, Boocock J, Trejo M, Le CQ, Guo L, Zhang Y, Sathe L, Arboleda VA, Yin Y, Bloom JS, Wang PC, Elmore JG, Kruglyak L, Shrestha L, Bakhash SAM, Lin M, Xie H, Huang ML, Roychoudhury P, Greninger A, Chandrasekaran S, Yang S, Garner OB. Retrospective Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California. Clin Infect Dis. 2022 01 29; 74(2):271-277. view on PubMed

Adamson PC, Pfeffer MA, Arboleda VA, Garner OB, de St Maurice A, von Bredow B, Flint J, Kruglyak L, Currier JS. Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California. Open Forum Infect Dis. 2021 Nov; 8(11):ofab526. view on PubMed

Guo F, McClain M, Zhao X, Yi K, Parmely T, Unruh J, Slaughter B, Kruglyak L, Guo L, Sánchez Alvarado A. Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining. J Vis Exp. 2021 09 10; (175). view on PubMed

Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nat Biomed Eng. 2021 07; 5(7):657-665. view on PubMed

Guo L, Bloom J, Sykes S, Huang E, Kashif Z, Pham E, Ho K, Alcaraz A, Xiao XG, Duarte-Vogel S, Kruglyak L. Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos. PLoS Genet. 2021 06; 17(6):e1009580. view on PubMed

Ben-David E, Boocock J, Guo L, Zdraljevic S, Bloom JS, Kruglyak L. Whole-organism eQTL mapping at cellular resolution with single-cell sequencing. Elife. 2021 03 18; 10. view on PubMed

Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv. 2021 Mar 09. view on PubMed

Boocock J, Sadhu MJ, Durvasula A, Bloom JS, Kruglyak L. Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast. Science. 2021 01 22; 371(6527):415-419. view on PubMed

Ben-David E, Pliota P, Widen SA, Koreshova A, Lemus-Vergara T, Verpukhovskiy P, Mandali S, Braendle C, Burga A, Kruglyak L. Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species. Curr Biol. 2021 03 08; 31(5):990-1001.e5. view on PubMed

Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW. Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross. Elife. 2020 11 12; 9. view on PubMed

Burga A, Ben-David E, Kruglyak L. Toxin-Antidote Elements Across the Tree of Life. Annu Rev Genet. 2020 11 23; 54:387-415. view on PubMed

Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell. 2019 11 27; 179(6):1424-1435.e8. view on PubMed

Bloom JS, Boocock J, Treusch S, Sadhu MJ, Day L, Oates-Barker H, Kruglyak L. Rare variants contribute disproportionately to quantitative trait variation in yeast. Elife. 2019 10 24; 8. view on PubMed

Zeevi D, Bloom JS, Sadhu MJ, Ben Yehuda A, Zangen D, Levy-Lahad E, Kruglyak L. Analysis of the genetic basis of height in large Jewish nuclear families. PLoS Genet. 2019 07; 15(7):e1008082. view on PubMed

Burga A, Ben-David E, Lemus Vergara T, Boocock J, Kruglyak L. Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nat Commun. 2019 06 18; 10(1):2680. view on PubMed

Gou L, Bloom JS, Kruglyak L. The Genetic Basis of Mutation Rate Variation in Yeast. Genetics. 2019 02; 211(2):731-740. view on PubMed

Sadhu MJ, Kruglyak L. How Low Can You Go? CRISPR J. 2018 10; 1:312-313. view on PubMed

Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L. Genetics of trans-regulatory variation in gene expression. Elife. 2018 07 17; 7. view on PubMed

Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L. Highly parallel genome variant engineering with CRISPR-Cas9. Nat Genet. 2018 Apr; 50(4):510-514. view on PubMed

Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 2017 08 17; 6. view on PubMed

Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J. The genetic basis of natural variation in a phoretic behavior. Nat Commun. 2017 08 17; 8(1):273. view on PubMed

Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017 Jun 02; 356(6341). view on PubMed

Ben-David E, Burga A, Kruglyak L. A maternal-effect selfish genetic element in Caenorhabditis elegans. Science. 2017 06 09; 356(6342):1051-1055. view on PubMed

Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö. Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. Nat Genet. 2017 Apr; 49(4):497-503. view on PubMed

Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics. 2016 09; 204(1):371-83. view on PubMed

Kruglyak L. Complex Traits and Simple Systems: An Interview with Leonid Kruglyak. Genetics. 2016 Jul; 203(3):1023-5. view on PubMed

Sadhu MJ, Bloom JS, Day L, Kruglyak L. CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science. 2016 May 27; 352(6289):1113-6. view on PubMed

Kruglyak L. 2015 Curt Stern Award. Am J Hum Genet. 2016 Mar 03; 98(3):428-430. view on PubMed

Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nat Commun. 2015 Nov 05; 6:8712. view on PubMed

Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L. Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics. 2015 Aug; 200(4):1327-39. view on PubMed

Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, Waterston RH. Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics. 2015 Jul; 200(3):975-89. view on PubMed

Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD. Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis. Genome Res. 2015 May; 25(5):667-78. view on PubMed

Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. G3 (Bethesda). 2015 Mar 13; 5(5):911-20. view on PubMed

Albert FW, Kruglyak L. The role of regulatory variation in complex traits and disease. Nat Rev Genet. 2015 Apr; 16(4):197-212. view on PubMed

Balla KM, Andersen EC, Kruglyak L, Troemel ER. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. PLoS Pathog. 2015 Feb; 11(2):e1004583. view on PubMed

Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L. Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae. PLoS Genet. 2015 Jan; 11(1):e1004913. view on PubMed

Wang X, Kruglyak L. Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. PLoS Genet. 2014 Dec; 10(12):e1004894. view on PubMed

Albert FW, Muzzey D, Weissman JS, Kruglyak L. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. view on PubMed

Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics. 2014 Nov; 198(3):1277-90. view on PubMed

Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. Genetic basis of metabolome variation in yeast. PLoS Genet. 2014 Mar; 10(3):e1004142. view on PubMed

Andersen EC, Bloom JS, Gerke JP, Kruglyak L. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. PLoS Genet. 2014 Feb; 10(2):e1004156. view on PubMed

Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L. Genetics of single-cell protein abundance variation in large yeast populations. Nature. 2014 Feb 27; 506(7489):494-7. view on PubMed

Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess DC. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda). 2013 04 09; 3(4):733-740. view on PubMed

Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet. 2013; 9(3):e1003329. view on PubMed

Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L. Finding the sources of missing heritability in a yeast cross. Nature. 2013 Feb 14; 494(7436):234-7. view on PubMed

Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet. 2012; 8(12):e1003157. view on PubMed

Ghosh R, Mohammadi A, Kruglyak L, Ryu WS. Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol. 2012 Oct 31; 10:85. view on PubMed

Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 2012 Dec; 192(4):1533-42. view on PubMed

Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science. 2012 Jul 27; 337(6093):470-3. view on PubMed

Ehrenreich IM, Bloom J, Torabi N, Wang X, Jia Y, Kruglyak L. Genetic architecture of highly complex chemical resistance traits across four yeast strains. PLoS Genet. 2012; 8(3):e1002570. view on PubMed

Torabi N, Kruglyak L. Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast. PLoS Genet. 2012; 8(3):e1002546. view on PubMed

Ghosh R, Andersen EC, Shapiro JA, Gerke JP, Kruglyak L. Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science. 2012 Feb 03; 335(6068):574-8. view on PubMed

Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix MA, Kruglyak L. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet. 2012 Jan 29; 44(3):285-90. view on PubMed

Khan Z, Bloom JS, Amini S, Singh M, Perlman DH, Caudy AA, Kruglyak L. Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS. Mol Syst Biol. 2012; 8:602. view on PubMed

Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S. Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome Biol. 2011 Dec 19; 12(12):R122. view on PubMed

Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol. 2011 Sep; 9(9):e1001144. view on PubMed

Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genet. 2011 Aug; 7(8):e1002250. view on PubMed

Torabi N, Kruglyak L. Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. PLoS Genet. 2011 Jul; 7(7):e1002211. view on PubMed

Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L. A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biol. 2011 Jul; 9(7):e1001115. view on PubMed

Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature. 2011 Apr 21; 472(7343):313-8. view on PubMed

Rockman MV, Skrovanek SS, Kruglyak L. Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science. 2010 Oct 15; 330(6002):372-6. view on PubMed

Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. 2010 Apr 15; 464(7291):1039-42. view on PubMed

Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1482-7. view on PubMed

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009 Oct 08; 461(7265):747-53. view on PubMed

Ehrenreich IM, Gerke JP, Kruglyak L. Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harb Symp Quant Biol. 2009; 74:145-53. view on PubMed

Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast. PLoS One. 2009 Sep 04; 4(9):e6907. view on PubMed

Khan Z, Bloom JS, Garcia BA, Singh M, Kruglyak L. Protein quantification across hundreds of experimental conditions. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15544-8. view on PubMed

Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE. Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics. 2009 Sep; 183(1):365-83. view on PubMed

Kruglyak L, Storey JD. Cause and express. Nat Biotechnol. 2009 Jun; 27(6):544-5. view on PubMed

Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA. Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics. 2009 May 12; 10:221. view on PubMed

Khan Z, Bloom JS, Kruglyak L, Singh M. A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays. Bioinformatics. 2009 Jul 01; 25(13):1609-16. view on PubMed

Rockman MV, Kruglyak L. Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet. 2009 Mar; 5(3):e1000419. view on PubMed

McGrath PT, Rockman MV, Zimmer M, Jang H, Macosko EZ, Kruglyak L, Bargmann CI. Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron. 2009 Mar 12; 61(5):692-9. view on PubMed

Schacherer J, Shapiro JA, Ruderfer DM, Kruglyak L. Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature. 2009 Mar 19; 458(7236):342-5. view on PubMed

Reddy KC, Andersen EC, Kruglyak L, Kim DH. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science. 2009 Jan 16; 323(5912):382-4. view on PubMed

Capra EJ, Skrovanek SM, Kruglyak L. Comparative developmental expression profiling of two C. elegans isolates. PLoS One. 2008; 3(12):e4055. view on PubMed

Coller HA, Kruglyak L. Genetics. It's the sequence, stupid! Science. 2008 Oct 17; 322(5900):380-1. view on PubMed

Gresham D, Kruglyak L. Rise of the machines. PLoS Genet. 2008 Aug 01; 4(8):e1000134. view on PubMed

Palopoli MF, Rockman MV, TinMaung A, Ramsay C, Curwen S, Aduna A, Laurita J, Kruglyak L. Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans. Nature. 2008 Aug 21; 454(7207):1019-22. view on PubMed

Demogines A, Smith E, Kruglyak L, Alani E. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. PLoS Genet. 2008 Jul 11; 4(7):e1000123. view on PubMed

Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet. 2008 Jul; 40(7):854-61. view on PubMed

Rockman MV, Kruglyak L. Breeding designs for recombinant inbred advanced intercross lines. Genetics. 2008 Jun; 179(2):1069-78. view on PubMed

Smith EN, Kruglyak L. Gene-environment interaction in yeast gene expression. PLoS Biol. 2008 Apr 15; 6(4):e83. view on PubMed

Kruglyak L. The road to genome-wide association studies. Nat Rev Genet. 2008 Apr; 9(4):314-8. view on PubMed

Seidel HS, Rockman MV, Kruglyak L. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science. 2008 Feb 01; 319(5863):589-94. view on PubMed

Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nat Genet. 2007 Nov; 39(11):1369-75. view on PubMed

Kruglyak L, Stern DL. Evolution. An embarrassment of switches. Science. 2007 Aug 10; 317(5839):758-9. view on PubMed

Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS One. 2007 Mar 28; 2(3):e322. view on PubMed

Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet. 2007 Apr; 39(4):496-502. view on PubMed

Rockman MV, Kruglyak L. Genetics of global gene expression. Nat Rev Genet. 2006 Nov; 7(11):862-72. view on PubMed

Ruderfer DM, Pratt SC, Seidel HS, Kruglyak L. Population genomic analysis of outcrossing and recombination in yeast. Nat Genet. 2006 Sep; 38(9):1077-81. view on PubMed

Eberle MA, Rieder MJ, Kruglyak L, Nickerson DA. Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome. PLoS Genet. 2006 Sep 08; 2(9):e142. view on PubMed

Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KD. Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science. 2006 Apr 28; 312(5773):577-9. view on PubMed

Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet. 2006 Mar; 2(3):e35. view on PubMed

Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science. 2006 Mar 31; 311(5769):1932-6. view on PubMed

Parker HG, Kruglyak L, Ostrander EA. Molecular genetics: DNA analysis of a putative dog clone. Nature. 2006 Mar 09; 440(7081):E1-2. view on PubMed

Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol. 2006 Mar; 13(3):319-27. view on PubMed

Kruglyak L. Power tools for human genetics. Nat Genet. 2005 Dec; 37(12):1299-300. view on PubMed

Ronald J, Brem RB, Whittle J, Kruglyak L. Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet. 2005 Aug; 1(2):e25. view on PubMed

Brem RB, Storey JD, Whittle J, Kruglyak L. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature. 2005 Aug 04; 436(7051):701-3. view on PubMed

Storey JD, Akey JM, Kruglyak L. Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol. 2005 Aug; 3(8):e267. view on PubMed

Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res. 2005 Feb; 15(2):284-91. view on PubMed

Brem RB, Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1572-7. view on PubMed

Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res. 2004 Dec; 14(12):2388-96. view on PubMed

Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N. No bias in linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):722-3; author reply 723-7. view on PubMed

Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol. 2004 Oct; 2(10):e286. view on PubMed

Carlson CS, Reider MJ, Nickerson DA, Eberle MA, Kruglyak L. Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'. Bioinformatics. 2005 Jan 15; 21(2):141-3. view on PubMed

Furman I, Rieder MJ, Da Ponte S, Carrington DP, Nickerson DA, Kruglyak L, Markianos K. Sequence-based linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):647-53. view on PubMed

Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature. 2004 May 27; 429(6990):446-52. view on PubMed

Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog. Science. 2004 May 21; 304(5674):1160-4. view on PubMed

Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Kruglyak L, Nickerson DA. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet. 2004 Apr; 74(4):610-22. view on PubMed

Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet. 2004 Jan; 74(1):106-20. view on PubMed

Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet. 2003 Sep; 35(1):57-64. view on PubMed

Matise TC, Sachidanandam R, Clark AG, Kruglyak L, Wijsman E, Kakol J, Buyske S, Chui B, Cohen P, de Toma C, Ehm M, Glanowski S, He C, Heil J, Markianos K, McMullen I, Pericak-Vance MA, Silbergleit A, Stein L, Wagner M, Wilson AF, Winick JD, Winn-Deen ES, Yamashiro CT, Cann HM, Lai E, Holden AL. A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet. 2003 Aug; 73(2):271-84. view on PubMed

Carlson CS, Eberle MA, Rieder MJ, Smith JD, Kruglyak L, Nickerson DA. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet. 2003 Apr; 33(4):518-21. view on PubMed

Brem RB, Yvert G, Clinton R, Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science. 2002 Apr 26; 296(5568):752-5. view on PubMed

Eberle MA, Pfützer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak L, Whitcomb DC, Brentnall TA. A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet. 2002 Apr; 70(4):1044-8. view on PubMed

Lindgren CM, Mahtani MM, Widén E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, Lander ES. Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. Am J Hum Genet. 2002 Feb; 70(2):509-16. view on PubMed

Subrahmanyan L, Eberle MA, Clark AG, Kruglyak L, Nickerson DA. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Am J Hum Genet. 2001 Aug; 69(2):381-95. view on PubMed

Markianos K, Daly MJ, Kruglyak L. Efficient multipoint linkage analysis through reduction of inheritance space. Am J Hum Genet. 2001 Apr; 68(4):963-77. view on PubMed

Kruglyak L, Nickerson DA. Variation is the spice of life. Nat Genet. 2001 Mar; 27(3):234-6. view on PubMed

Markianos K, Carlson S, Gibbs M, Kruglyak L. A joint analysis of asthma affection status and IgE levels in multiple data sets collected for asthma. Genet Epidemiol. 2001; 21 Suppl 1:S148-53. view on PubMed

Altshuler D, Daly M, Kruglyak L. Guilt by association. Nat Genet. 2000 Oct; 26(2):135-7. view on PubMed

Yang Z, Wong GK, Eberle MA, Kibukawa M, Passey DA, Hughes WR, Kruglyak L, Yu J. Sampling SNPs. Nat Genet. 2000 Sep; 26(1):13-4. view on PubMed

Ostrander EA, Kruglyak L. Unleashing the canine genome. Genome Res. 2000 Sep; 10(9):1271-4. view on PubMed

Rasko JE, Battini JL, Kruglyak L, Cox DR, Miller AD. Precise gene localization by phenotypic assay of radiation hybrid cells. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7388-92. view on PubMed

Nancarrow DJ, Levinson DF, Taylor JM, Hayward NK, Walters MK, Lennon DP, Nertney DA, Jones HL, Mahtani MM, Kirby A, Kruglyak L, Brown DM, Crowe RR, Andreasen NC, Black DW, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Mowry BJ. No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. Am J Med Genet. 2000 Apr 03; 96(2):224-7. view on PubMed

Pratt SC, Daly MJ, Kruglyak L. Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet. 2000 Mar; 66(3):1153-7. view on PubMed

Eberle MA, Kruglyak L. An analysis of strategies for discovery of single-nucleotide polymorphisms. Genet Epidemiol. 2000; 19 Suppl 1:S29-35. view on PubMed

Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, McInnis M, Simpson S, McMahon F, Stine OC, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, Folstein S, Daly M, Kruglyak L, Marr T, DePaulo JR, Botstein D. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am J Hum Genet. 2000 Jan; 66(1):205-15. view on PubMed

Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999 Jun; 22(2):139-44. view on PubMed

Kruglyak L. Genetic isolates: separate but equal? Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1170-2. view on PubMed

Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, Walters MK, Lennon DP, Jones HL, Nertney DA, Daly MJ, Gladis M, Mowry BJ. Genome scan of schizophrenia. Am J Psychiatry. 1998 Jun; 155(6):741-50. view on PubMed

Altshuler D, Kruglyak L, Lander E. Genetic polymorphisms and disease. N Engl J Med. 1998 May 28; 338(22):1626. view on PubMed

Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer. Lancet. 1998 May 23; 351(9115):1560. view on PubMed

Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 1998 May 15; 280(5366):1077-82. view on PubMed

Kruglyak L, Daly MJ. Linkage thresholds for two-stage genome scans. Am J Hum Genet. 1998 Apr; 62(4):994-7. view on PubMed

Kruglyak L, McAllister L. Who needs genetic markers? Nat Genet. 1998 Mar; 18(3):200-2. view on PubMed

Kruglyak L, Lander ES. Faster multipoint linkage analysis using Fourier transforms. J Comput Biol. 1998; 5(1):1-7. view on PubMed

McCarthy MI, Kruglyak L, Lander ES. Sib-pair collection strategies for complex diseases. Genet Epidemiol. 1998; 15(4):317-40. view on PubMed

Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet. 1997 Nov; 6(12):2069-76. view on PubMed

Kruglyak L. What is significant in whole-genome linkage disequilibrium studies? Am J Hum Genet. 1997 Oct; 61(4):810-2. view on PubMed

Kruglyak L. The use of a genetic map of biallelic markers in linkage studies. Nat Genet. 1997 Sep; 17(1):21-4. view on PubMed

Kruglyak L. Nonparametric linkage tests are model free. Am J Hum Genet. 1997 Jul; 61(1):254-5. view on PubMed

Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May; 18(5):711-22. view on PubMed

Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):587-92. view on PubMed

Slonim D, Kruglyak L, Stein L, Lander E. Building human genome maps with radiation hybrids. J Comput Biol. 1997; 4(4):487-504. view on PubMed

Daly M, Kirby A, Kruglyak L. Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? Genet Epidemiol. 1997; 14(6):599-604. view on PubMed

Kruglyak L. Thresholds and sample sizes. Nat Genet. 1996 Oct; 14(2):132-3. view on PubMed

Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet. 1996 Sep; 14(1):90-4. view on PubMed

Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. A locus for Fanconi anemia on 16q determined by homozygosity mapping. Am J Hum Genet. 1996 Aug; 59(2):377-84. view on PubMed

Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996 Jun; 58(6):1347-63. view on PubMed

Kruglyak L, Lander ES. Limits on fine mapping of complex traits. Am J Hum Genet. 1996 May; 58(5):1092-3. view on PubMed

Levy EN, Shen Y, Kupelian A, Kruglyak L, Aksentijevich I, Pras E, Balow JE, Linzer B, Chen X, Shelton DA, Gumucio D, Pras M, Shohat M, Rotter JI, Fischel-Ghodsian N, Richards RI, Kastner DL. Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246. Am J Hum Genet. 1996 Mar; 58(3):523-34. view on PubMed

Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22; 379(6567):736-9. view on PubMed

Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Fauré S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES. An STS-based map of the human genome. Science. 1995 Dec 22; 270(5244):1945-54. view on PubMed

Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995 Nov; 11(3):241-7. view on PubMed

Hu S, Pattatucci AM, Patterson C, Li L, Fulker DW, Cherny SS, Kruglyak L, Hamer DH. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat Genet. 1995 Nov; 11(3):248-56. view on PubMed

Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 1995 Aug; 57(2):439-54. view on PubMed

Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits. Am J Hum Genet. 1995 May; 56(5):1212-23. view on PubMed

Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics. 1995 Mar; 139(3):1421-8. view on PubMed

Kruglyak L, Daly MJ, Lander ES. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet. 1995 Feb; 56(2):519-27. view on PubMed

Kruglyak L. Sexual orientation. Nature. 1993 Oct 21; 365(6448):702. view on PubMed