Kent Hill*
Publications:
Shimogawa MM, Jonnalagadda K, Hill KL. FAP20 is required for flagellum assembly in Trypanosoma brucei. bioRxiv. 2024 Jan 20. view on PubMed
Shimogawa MM, Wijono AS, Wang H, Zhang J, Sha J, Szombathy N, Vadakkan S, Pelayo P, Jonnalagadda K, Wohlschlegel J, Zhou ZH, Hill KL. FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction. Nat Commun. 2023 08 26; 14(1):5225. view on PubMed
Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. Author Correction: Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Cell Discov. 2021 Aug 06; 7(1):61. view on PubMed
Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Cell Discov. 2021 Jul 13; 7(1):51. view on PubMed
Walsh B, Hill KL. Right place, right time: Environmental sensing and signal transduction directs cellular differentiation and motility in Trypanosoma brucei. Mol Microbiol. 2021 05; 115(5):930-941. view on PubMed
Vélez-Ramírez DE, Shimogawa MM, Ray SS, Lopez A, Rayatpisheh S, Langousis G, Gallagher-Jones M, Dean S, Wohlschlegel JA, Hill KL. APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei. mSphere. 2021 02 10; 6(1). view on PubMed
DeMarco SF, Saada EA, Lopez MA, Hill KL. Identification of Positive Chemotaxis in the Protozoan Pathogen Trypanosoma brucei. mSphere. 2020 08 12; 5(4). view on PubMed
Imhof S, Zhang J, Wang H, Bui KH, Nguyen H, Atanasov I, Hui WH, Yang SK, Zhou ZH, Hill KL. Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei. Elife. 2019 11 11; 8. view on PubMed
Shaw S, DeMarco SF, Rehmann R, Wenzler T, Florini F, Roditi I, Hill KL. Flagellar cAMP signaling controls trypanosome progression through host tissues. Nat Commun. 2019 02 18; 10(1):803. view on PubMed
Zhang Y, Ceylan Koydemir H, Shimogawa MM, Yalcin S, Guziak A, Liu T, Oguz I, Huang Y, Bai B, Luo Y, Luo Y, Wei Z, Wang H, Bianco V, Zhang B, Nadkarni R, Hill K, Ozcan A. Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning. Light Sci Appl. 2018; 7:108. view on PubMed
Shimogawa MM, Ray SS, Kisalu N, Zhang Y, Geng Q, Ozcan A, Hill KL. Parasite motility is critical for virulence of African trypanosomes. Sci Rep. 2018 06 14; 8(1):9122. view on PubMed
Marti M, Hill KL. Sensing and signaling in parasitism. Mol Biochem Parasitol. 2016 07; 208(1):1. view on PubMed
Langousis G, Shimogawa MM, Saada EA, Vashisht AA, Spreafico R, Nager AR, Barshop WD, Nachury MV, Wohlschlegel JA, Hill KL. Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):632-7. view on PubMed
Saada EA, DeMarco SF, Shimogawa MM, Hill KL. "With a Little Help from My Friends"-Social Motility in Trypanosoma brucei. PLoS Pathog. 2015 Dec; 11(12):e1005272. view on PubMed
Shimogawa MM, Saada EA, Vashisht AA, Barshop WD, Wohlschlegel JA, Hill KL. Cell Surface Proteomics Provides Insight into Stage-Specific Remodeling of the Host-Parasite Interface in Trypanosoma brucei. Mol Cell Proteomics. 2015 Jul; 14(7):1977-88. view on PubMed
Oberholzer M, Saada EA, Hill KL. Cyclic AMP Regulates Social Behavior in African Trypanosomes. mBio. 2015 Apr 28; 6(3):e01954-14. view on PubMed
Lopez MA, Saada EA, Hill KL. Insect stage-specific adenylate cyclases regulate social motility in African trypanosomes. Eukaryot Cell. 2015 Jan; 14(1):104-12. view on PubMed
Langousis G, Hill KL. Motility and more: the flagellum of Trypanosoma brucei. Nat Rev Microbiol. 2014 Jul; 12(7):505-18. view on PubMed
Freire ER, Vashisht AA, Malvezzi AM, Zuberek J, Langousis G, Saada EA, Nascimento Jde F, Stepinski J, Darzynkiewicz E, Hill K, De Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei. RNA. 2014 Aug; 20(8):1272-86. view on PubMed
Saada EA, Kabututu ZP, Lopez M, Shimogawa MM, Langousis G, Oberholzer M, Riestra A, Jonsson ZO, Wohlschlegel JA, Hill KL. Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane. Eukaryot Cell. 2014 Aug; 13(8):1064-76. view on PubMed
Freire ER, Malvezzi AM, Vashisht AA, Zuberek J, Saada EA, Langousis G, Nascimento JD, Moura D, Darzynkiewicz E, Hill K, de Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog. Eukaryot Cell. 2014 Jul; 13(7):896-908. view on PubMed
Kisalu NK, Langousis G, Bentolila LA, Ralston KS, Hill KL. Mouse infection and pathogenesis by Trypanosoma brucei motility mutants. Cell Microbiol. 2014 Jun; 16(6):912-24. view on PubMed
Nguyen HT, Sandhu J, Langousis G, Hill KL. CMF22 is a broadly conserved axonemal protein and is required for propulsive motility in Trypanosoma brucei. Eukaryot Cell. 2013 Sep; 12(9):1202-13. view on PubMed
Freund JB, Goetz JG, Hill KL, Vermot J. Fluid flows and forces in development: functions, features and biophysical principles. Development. 2012 Apr; 139(7):1229-45. view on PubMed
Hughes LC, Ralston KS, Hill KL, Zhou ZH. Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. PLoS One. 2012; 7(1):e25700. view on PubMed
Lopez MA, Nguyen HT, Oberholzer M, Hill KL. Social parasites. Curr Opin Microbiol. 2011 Dec; 14(6):642-8. view on PubMed
Oberholzer M, Langousis G, Nguyen HT, Saada EA, Shimogawa MM, Jonsson ZO, Nguyen SM, Wohlschlegel JA, Hill KL. Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei. Mol Cell Proteomics. 2011 Oct; 10(10):M111.010538. view on PubMed
Ralston KS, Kisalu NK, Hill KL. Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei. Eukaryot Cell. 2011 Jul; 10(7):884-94. view on PubMed
Kabututu ZP, Thayer M, Melehani JH, Hill KL. CMF70 is a subunit of the dynein regulatory complex. J Cell Sci. 2010 Oct 15; 123(Pt 20):3587-95. view on PubMed
Hill KL. Parasites in motion: flagellum-driven cell motility in African trypanosomes. Curr Opin Microbiol. 2010 Aug; 13(4):459-65. view on PubMed
Oberholzer M, Lopez MA, McLelland BT, Hill KL. Social motility in african trypanosomes. PLoS Pathog. 2010 Jan 29; 6(1):e1000739. view on PubMed
Oberholzer M, Lopez MA, Ralston KS, Hill KL. Approaches for functional analysis of flagellar proteins in African trypanosomes. Methods Cell Biol. 2009; 93:21-57. view on PubMed
Rodríguez JA, Lopez MA, Thayer MC, Zhao Y, Oberholzer M, Chang DD, Kisalu NK, Penichet ML, Helguera G, Bruinsma R, Hill KL, Miao J. Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19322-7. view on PubMed
Ralston KS, Kabututu ZP, Melehani JH, Oberholzer M, Hill KL. The Trypanosoma brucei flagellum: moving parasites in new directions. Annu Rev Microbiol. 2009; 63:335-62. view on PubMed
Colantonio JR, Vermot J, Wu D, Langenbacher AD, Fraser S, Chen JN, Hill KL. The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature. 2009 Jan 08; 457(7226):205-9. view on PubMed
Ralston KS, Hill KL. The flagellum of Trypanosoma brucei: new tricks from an old dog. Int J Parasitol. 2008 Jul; 38(8-9):869-84. view on PubMed
Bekker JM, Colantonio JR, Stephens AD, Clarke WT, King SJ, Hill KL, Crosbie RH. Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. Cell Motil Cytoskeleton. 2007 Jun; 64(6):461-73. view on PubMed
Baron DM, Kabututu ZP, Hill KL. Stuck in reverse: loss of LC1 in Trypanosoma brucei disrupts outer dynein arms and leads to reverse flagellar beat and backward movement. J Cell Sci. 2007 May 01; 120(Pt 9):1513-20. view on PubMed
Baron DM, Ralston KS, Kabututu ZP, Hill KL. Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella. J Cell Sci. 2007 Feb 01; 120(Pt 3):478-91. view on PubMed
Ralston KS, Hill KL. Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. PLoS Pathog. 2006 Sep; 2(9):e101. view on PubMed
Colantonio JR, Bekker JM, Kim SJ, Morrissey KM, Crosbie RH, Hill KL. Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. Traffic. 2006 May; 7(5):538-48. view on PubMed
Ralston KS, Lerner AG, Diener DR, Hill KL. Flagellar motility contributes to cytokinesis in Trypanosoma brucei and is modulated by an evolutionarily conserved dynein regulatory system. Eukaryot Cell. 2006 Apr; 5(4):696-711. view on PubMed
Hill KL. Biology and mechanism of trypanosome cell motility. Eukaryot Cell. 2003 Apr; 2(2):200-8. view on PubMed
Hutchings NR, Donelson JE, Hill KL. Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes. J Cell Biol. 2002 Mar 04; 156(5):867-77. view on PubMed
