Evan Dale Abel

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Evan Dale Abel, M.D., Ph.D.
Office Address:
757 Westwood Plaza, Suite 7236
Affiliations

Professor, Chair and Executive Medical Director Medicine

Research Interests

My own laboratory is focused on understanding the molecular mechanisms that are responsible for cardiac dysfunction in obesity, type 2 diabetes and type 1 diabetes, and in elucidating the role of mitochondrial dysfunction in skeletal muscle, adipose tissue and platelets in the pathogenesis of insulin resistance, obesity and its cardiovascular complications. Our contributions have elucidated the contribution of oxidative stress in impairing mitochondrial bioenergetics in obesity and diabetes, the pleiotropic effects of insulin and growth factor signaling in cardiac hypertrophy, autophagy, mitochondrial dynamics and mitochondrial bioenergetics. We elucidated the contribution of hyperinsulinemia to cardiac pathology in diabetes and obesity, mechanisms linking lipotoxicity and mitochondrial dynamics and mechanisms linking altered myocardial glucose metabolism with heart failure.

Publications

A selected list of publications:

 

Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages. Circ Res. 2022 03 04; 130(5):779-781. Matsuura Y, Shimizu-Albergine M, Barnhart S, Kramer F, Hsu CC, Kothari V, Tang J, Gharib SA, Kanter JE, Abel ED, Tian R, Shao B, Bornfeldt KE. PMID: 35170337; PMCID: PMC8897241.
Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. Autophagy. 2022 09; 18(9):2161-2177. Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA. PMID: 35104184; PMCID: PMC9466614.
Protocols for Generating Surfaces and Measuring 3D Organelle Morphology Using Amira. Cells. 2021 12 27; 11(1). Garza-Lopez E, Vue Z, Katti P, Neikirk K, Biete M, Lam J, Beasley HK, Marshall AG, Rodman TA, Christensen TA, Salisbury JL, Vang L, Mungai M, AshShareef S, Murray SA, Shao J, Streeter J, Glancy B, Pereira RO, Abel ED, Hinton A. PMID: 35011629; PMCID: PMC8750564.
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Biochem J. 2021 10 15; 478(19):3539-3553. Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. PMID: 34524407; PMCID: PMC8589432.
Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. FASEB J. 2021 10; 35(10):e21933. Morales PE, Monsalves-Álvarez M, Tadinada SM, Harris MP, Ramírez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Lavandero S. PMID: 34555201.
Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest. 2021 09 15; 131(18). Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton AO, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O’Neill BT. PMID: 34343133; PMCID: PMC8439595.
Functional resilience of C57BL/6J mouse heart to dietary fat overload. Am J Physiol Heart Circ Physiol. 2021 11 01; 321(5):H850-H864. Tadinada SM, Weatherford ET, Collins GV, Bhardwaj G, Cochran J, Kutschke W, Zimmerman K, Bosko A, O’Neill BT, Weiss RM, Abel ED. PMID: 34477461; PMCID: PMC8616610.
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ. Cells. 2021 08 24; 10(9). Lam J, Katti P, Biete M, Mungai M, AshShareef S, Neikirk K, Garza Lopez E, Vue Z, Christensen TA, Beasley HK, Rodman TA, Murray SA, Salisbury JL, Glancy B, Shao J, Pereira RO, Abel ED, Hinton A. PMID: 34571826; PMCID: PMC8465115.
Insulin signaling in the heart. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E130-E145. Abel ED. PMID: 34056923; PMCID: PMC8321827.
Cardiac Energy Metabolism in Heart Failure. Circ Res. 2021 05 14; 128(10):1487-1513. Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. PMID: 33983836; PMCID: PMC8136750.
OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. Elife. 2021 05 04; 10. Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bùi Trân W, García-Peña LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. PMID: 33944779; PMCID: PMC8128440.
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021 06; 169:317-342. Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. PMID: 33910093; PMCID: PMC8285002.
Counterpoint: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E1001-E1002. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33843282; PMCID: PMC8238130.
Reply to Petersen et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E1004-E1005. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. PMID: 33843283; PMCID: PMC8238129.
GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. Cancer Res. 2021 05 01; 81(9):2345-2357. Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. PMID: 33753374; PMCID: PMC8137580.
mTOR Mediated Metabolic Rewiring and Ischemic Preconditioning, its Complicated. Circ Res. 2021 03 05; 128(5):652-654. Abel ED. PMID: 34219792; PMCID: PMC8244748.
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Am J Physiol Heart Circ Physiol. 2021 04 01; 320(4):H1470-H1485. Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. PMID: 33577435.
An early endothelial cell-specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice. JCI Insight. 2021 02 08; 6(3). Tang M, Park SH, Petri S, Yu H, Rueda CB, Abel ED, Kim CY, Hillman EM, Li F, Lee Y, Ding L, Jagadish S, Frankel WN, De Vivo DC, Monani UR. PMID: 33351789; PMCID: PMC7934852.
It takes a village: lessons from collaborative science. J Clin Invest. 2021 01 19; 131(2). Abel ED. PMID: 33463544; PMCID: PMC7810490.