Terasaki Life Sciences Building 3031
Los Angeles, CA 90095
Member, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
Member, Jonsson Comprehensive Cancer Center
Member, Molecular Biology Institute; Immunity, Microbes & Molecular Pathogenesis GPB Home Area
The Seet Laboratory is focused on the study of human lymphocyte development and function and its application to tumor immunology and cancer immunotherapy. The Lab seeks to broadly understand how T cell development from stem and progenitor cells can be directed to enhance T cell function and anti-tumor efficacy, with a focus on developing new approaches to immune cell therapy for cancer. Current projects include the in vitro generation of tumor antigen-specific TCRs, characterization of novel receptor pathways in T cell-tumor cell interactions, and modification of in vitro T cell differentiation to generate T cells with enhanced in vivo anti-tumor potential from pluripotent stem cells. The Lab is particularly interested in the development of immunotherapeutic approaches to treat hematologic malignancies, Dr. Seet’s clinical subspecialty. The Seet Lab incorporates methods in molecular and cell biology and immunology including lentiviral gene delivery, gene editing, single-cell RNA-seq and TCR sequencing, flow cytometry, human immune cell functional assays, and in vivo modeling of human immune cell function in tumor xenograft models. The Lab fosters a highly collaborative environment for trainees at all levels to pursue scientific investigation with an emphasis on creativity, innovation, and clinical significance.