Gene Regulation


Studies spanning the past three decades have revealed that differential gene expression is one of the most widely used modes of cellular regulation in both normal physiological processes such as development and differentiation and aberrant processes such as cancer. The Gene Regulation Home Area’s mission is to train students in the principles and concepts of contemporary gene regulation research with an emphasis on developing skills in cellular, proteomic and genome-wide analyses in order to study mechanisms of differential gene expression during cell signaling, differentiation, development and disease. Our program consists of a specialized curriculum focused on generating a comprehensive understanding of current concepts and mechanisms of gene regulation at the fundamental level and in relation to specific biological pathways. Our group’s studies range from basic biochemical analysis of chromatin transcription to detailed analysis of RNA-based pathways involved in cancer. There is a strong emphasis on understanding the epigenome, the pattern of DNA and histone modifications that facilitate transcriptional regulatory decisions. Our group teaches students how to properly employ state-of-the-art technologies like deep sequencing, informatics and mass spectrometry in order to understand the dynamics of gene regulation in organisms ranging from plants to man. Upon graduation, our students are equipped with the intellectual background and methodological training to enter exciting and highly technical areas of the gene expression field in both academics and industry.

journal clubIntramural


Kimberly Insigne from Dr. Kosuri’s Lab will present the following paper on Friday, May 26th a t 1pm in BSRB 383.

Systematic Investigation of Transcription Factor Activity in the Context of Chromatin Using Massively Parallel Binding and Expression Assays. Michal Levo, Tali Avnit-Sagi, Maya Lotan-Pompan, Yael Kalma, Adina Weinberger, Zohar Yakhini, Eran Segal. Cell Volume 65, Issue 4, p604–617.e6, 16 February 2017.



Researchers explore a new method to study cholesterol distribution on cells

Findings could eventually help identify mechanisms linking cholesterol to coronary artery disease

Researchers from UCLA and the University of Western Australia have developed a new way of visualizing the distribution of cholesterol in cells and tissues. Their research provides insights into the movement of cholesterol into and out of cells and could eventually identify mechanisms linking cholesterol to coronary artery disease. Read more here…

Home Area Director

DSC_0028-Mike Carey_small509Michael Carey, Ph.D. BSRB 351A 310-206-7859