Brenner Fellowship

Aimee and Jules 040618
Courtney Young

2018 winner Aimee Flores (Bill Lowry lab). Aimee’s work uses hair follicle stem cells to study how cells regulate their metabolism and how tumors are formed.

Nature Cell Biology. 2017 August 14; 1017-1026. “Lactate dehydrogenase activity drives hair follicle stem cell activation.” Flores A1,2,3, Schell J4, Krall AS5, Jelinek D1, Miranda M1, Grigorian M6, Braas D5,7, White AC8, Zhou JL9, Graham NA5,9, Graeber T5,10, Seth P11, Evseenko D12, Coller HA1,2,3,13,14, Rutter J4,15, Christofk HR2,5,7,13,14, Lowry WE1,2,3,13.

Wiley Online Library. 2016 April 20; 733-735. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma.
Flores A1,2, Grant W1, White AC3, Scumpia P4, Takahashi R4, Lowry WE1,2,4,5,6

2017 winner, Courtney Young (Melissa Spencer lab). Courtney’s work centers on genetic therapies for Duchenne Muscular Dystrophy.

Cell. 2016 Nov 17;167(5):1144. Exon Skipping Therapy
Young CS1, Pyle AD2.
Cell Stem Cell. 2016 Apr 7;18(4):533-40. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells.
Young CS1, Hicks MR2, Ermolova NV3, Nakano H4, Jan M5, Younesi S5, Karumbayaram S6, Kumagai-Cresse C3, Wang D7, Zack JA8, Kohn DB9, Nakano A10, Nelson SF11, Miceli MC9, Spencer MJ12, Pyle AD13.



2016 winner, Lulan Wang (Genhong Cheng lab). Lulan’s work highlighted how the Zika virus mutates rapidly and evades the body’s immune system.

Cell Host Microbe. 2016 May 11;19(5):561-5 From Mosquitos to Humans: Genetic Evolution of Zika Virus.
Wang L, Valderramos SG, Wu A, Ouyang S, Li C, Brasil P, Bonaldo M, Coates T, Nielsen-Saines K, Jiang T, Aliyari R, Cheng G.




2015 winner, Kevin Roy (Guillaume Chanfreau lab), with Mr Brenner. Kevin’s work has provided insights into how the cell controls it’s gene expression in response to environmental stress.

PLoS Genet. 2014 Sep 18 Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival. Roy K1, Chanfreau G1.
Genome Res. 2016 Oct;26(10):1363-1375. Common genomic elements promote transcriptional and DNA replication roadblocks. Roy K1, Gabunilas J2, Gillespie A2, Ngo D2, Chanfreau GF1.