Nathan Zemke

Nathan Zemke

Home Area: Gene Regulation, Epigenomics and Transcriptomics
Mentor: Arnold Berk
Research project:

Characterizing the mechanisms of adenoviral E1A cellular reprogramming by examining its influence on gene expression and interacting cellular proteins.


Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection. Ferrari R, Gou D, Jawdekar G, Johnson SA, Nava M, Su T, Yousef AF, Zemke NR, Pellegrini M, Kurdistani SK, Berk AJ. Cell Host Microbe. 2014 Nov 12;16(5):663-76. doi: 10.1016/j.chom.2014.10.004. Epub 2014 Nov 12.

The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling. Zemke NR, Berk AJ. Cell Host Microbe. 2017 Dec 13;22(6):789-800.e5. doi: 10.1016/j.chom.2017.11.008.