Jessica is examining the physiological roles of a protein called Diet1 in the mouse model organism. A lack of Diet1 has previously been shown to make mice less susceptible to hypercholesterolemia when put on an atherogenic diet due to an enhanced bile acid secretion phenotype.
Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants. Lee, J. M.*, Ong, J. R.*, Vergnes, L., de Aguiar Vallim, T. Q., Nolan, J., Cantor, R. M., Walters, J. R. F., and Reue, K. Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants. Lipid Res. (2018); 59(3):429-438.
Hmga2 is dispensable for cutaneous squamous cell carcinoma. White A, Flores A, Ong J, Lowry WE. Exp Dermatol. 2016 May;25(5):409-12. doi: 10.1111/exd.12978