Calvin Leung

Calvin Leung

Home Area: Biochemistry, Biophysics, and Structural Biology
Mentor: Tracy Johnson

Research project:

Calvin is studying how histone modifications and chromatin factors regulate pre-mRNA splicing in yeast.

Publications:

The Exon Junction Complex: A Multitasking Guardian of the TranscriptomeLeung CS, and Johnson TL. The Exon Junction Complex: A Multitasking Guardian of the Transcriptome. Molecular Cell. 2018; 27(13): 3760-3769. doi: 10.1016/j.molcel.2018.11.030

H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome AssemblyLeung CS, Douglass SM, Morselli M, Obusan MB, Pavlyukov MS, Pellegrini M, and Johnson TL. H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome Assembly. Cell Reports. 2019; 27(13): 3760-3769

Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, and Beigneux AP. J Biol Chem. 2014; 289(28): 19491-9. doi: 10.1074/jbc.M114.558528

Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter. Turlo K, Leung CS, Seo JJ, Goulbourne CN, Adeyo O, Gin P, Voss C, Bensadoun A, Fong LG, Young SG, and Beigneux AP. Biochim Biophys Acta. 2014; 1841(7): 963-9. doi: 10.1016/j.bbalip.2014.03.011

A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, and Beigneux AP. Biochim Biophys Acta. 2014; 1841(7): 970-6. doi: 10.1016/j.bbalip.2014.03.008

High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population. Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, and Abramson J. High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population. J Biol Chem. 2014; 289(18): 12566-77. doi: 10.1074/jbc.M113.497438