Molecular Biology Institute

MBI Thursday Research Seminar | Clifford Brangwynne, Ph.D. | Hosted by Margot Quinlan and Kathrin Plath
2021-04-08 09:00 - 10:00 (America/Los_Angeles) | Zoom
“Fluid forces – phase separation in, on, and around the genome”
Clifford Brangwynne, Ph.D.
Director, Princeton Bioengineering Initiative
June K. Wu ’92 Professor in Engineering
Professor of Chemical and Biological Engineering
Princeton University

Please email mbiasst@lifesci.ucla.edu to request Zoom link.

MBI Faculty Seminar - Aparna Bhaduri, Ph.D.
2021-04-06 12:00 - 13:00 | CA
“An Atlas of Cortical Arealization Identifies Dynamic Molecular Signatures”
Aparna Bhaduri, Ph.D.
Assistant Professor, Biological Chemistry

All MBI Faculty Welcome

MBI Thursday Research Seminar | Sabine Petry, Ph.D. | Hosted by Margot Quinlan
2021-04-01 09:00 - 10:00 | Zoom
“How to make microtubules and build the cytoskeleton”
Sabine Petry, Ph.D.
Associate Professor, Molecular Biology
Princeton University
Abstract:
How does a cell construct its microtubule cytoskeleton? According to Feynman’s principle “what I cannot create, I do not understand”, my lab pursues this question by building the chromosome segregation machinery from scratch. I will first tell you how the microtubule framework is generated in a cell. Upon deciphering the function of the most important microtubule accessory proteins, I will present how we use those building blocks to reconstitute a spindle substructure in vitro and determine its building plan. Finally, I will outline how we combine spindle substructures like pieces of a puzzle to assemble and thereby understand a functioning spindle that segregates chromosomes.
By studying how the MT cytoskeleton is built, I hope to help explain how hundreds of proteins can self-assemble on the nm scale into a complex molecular machine 1000-fold larger than its constituents, a challenge for the biochemistry of the 21st century

Please email mbiasst@lifesci.ucla.edu to request Zoom link.

Journey Talk - Elizabeth Zuniga-Sanchez, Ph.D.
2021-03-31 13:00 - 14:00 | Zoom
“Unraveling the molecular code in neural circuit assembly”
Elizabeth Zuniga-Sanchez, Ph.D.
Assistant Professor, Ophthalmology
Baylor College of Medicine

William Weis, Ph.D. | Hosted by Jie Zheng
2021-03-11 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Force-dependent allosteric regulation of cell-cell adhesion”
William Weis, Ph.D.
William M. Hume Professor in the School of Medicine,
Professor of Structural Biology, of Molecular and Cellular Physiology and of Photon Science
Stanford University

Please email mbiasst@lifesci.ucla.edu for Zoom link.

Journey Talk - Andrew Goldstein, Ph.D.
2021-03-10 13:00 - 14:00 | Zoom
“A scientific journey of learning”
Andrew Goldstein, Ph.D.
Assistant Professor, Molecular, Cell and Developmental Biology

Harold Pimentel, Ph.D.
2021-03-09 12:00 - 13:00 | Zoom
Harold Pimentel, Ph.D.
Assistant Professor, Computational Medicine, Human Genetics

Luciano Marraffini, Ph.D. | Hosted by Hung Ton-That
2021-03-04 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“CRISPR-Cas13 immunity: sacrificing the host for the population”
Luciano Marraffini, Ph.D.
Investigator, Howard Hughes Medical Institute
Professor and Head, Laboratory of Bacteriology
The Rockefeller University

Eri Srivatsan, Ph.D.
2021-03-02 12:00 - 13:00 | Zoom
Eri Srivatsan, Ph.D.
Professor, Surgery

Marisa Bartolomei, Ph.D. | Hosted by Patrick Allard
2021-02-25 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Epigenetic Regulation of Imprinting in Clusters”
Marisa Bartolomei, Ph.D.
Perelman Professor of Cell & Developmental Biology
Co-Director, Epigenetics Institute
University of Pennsylvania Perelman School of Medicine

Pearl Quijada, Ph.D.
2021-02-23 12:00 - 13:00 | Zoom
Pearl Quijada, Ph.D.
Assistant Professor, Integrative Biology & Physiology

David Fajgenbaum, MD, MBA, MSc | Hosted by Elizabeth Tarling
2021-02-18 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Personalized, Personalized Medicine: Lessons Learned While Chasing My Cure”
David Fajgenbaum, MD, MBA, MSc
Assistant Professor, Medicine
Perelman School of Medicine
University of Pennsylvania

Suraj Bhat, Ph.D.
2021-02-16 12:00 - 13:00 | Zoom
Suraj Bhat, Ph.D.
Professor, Ophthalmology

MBIDP Student Defense - Shawn Tan
2021-02-11 16:00 - 18:00 | Zoom

Tzung K. Hsiai, M.D., Ph.D. | Hosted by Jie Zheng
2021-02-11 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Light at the End of SARS-CoV-2: Integrating 4-D Light-Sheet and Light-Field to Elucidate Cardiac Morphogenesis”
Tzung K. Hsiai, MD, PhD
Professor of Medicine and Bioengineering
UCLA Cardiovascular Engineering & Light-Sheet Imaging Laboratory
Maud Cady Guthman Endowed Chair in Cardiology
Abstract: During cardiac development, peristaltic contraction of the embryonic heart tube produces time-varying hemodynamic forces and pressure gradients across the atrioventricular canal. However, the relative importance of myocardial contraction and hemodynamic force to modulate cardiac morphogenesis remain poorly understood. By using dual illumination and dual detection light-sheet system, we recapitulate flow-mediated Notch1b-Nrg1-ErbB2 signaling underlying the initiation of endocardial trabeculation for contractile function. We demonstrate myocardial contractile force-mediated Notch1b-endothealial mesenchymal transition underlying valvulogenesis in the ventricular outflow tract. Overall, we integrate advanced optics with zebrafish genetics to provide biomechanical insights into cardiac development with translational implications for congenital heart disease.

Please email mbiasst@lifesci.ucla.edu to request Zoom link.

Jodi Nunnari, Ph.D. | Hosted by Catherine Clarke and Alexa Novales
2021-02-04 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Mitochondrial Behavior”
Jodi Nunnari, Ph.D.
Distinguished Professor, Molecular and Cellular Biology
University of California, Davis

Alexander Hoffmann, Ph.D.
2021-02-02 12:00 - 13:00 | Zoom
Alexander Hoffmann, Ph.D.
Professor, Microbiology, Immunology & Molecular Genetics

MBI Postdoc Chalk Talk - Daniel Velez-Ramirez, Ph.D.
2021-01-28 16:00 - 17:00 | Zoom

Yongsheng Shi, Ph.D. | Hosted by Douglas Black
2021-01-28 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Targeting mRNA 3’ end processing in cancer therapy”
Yongsheng Shi, Ph.D.
Professor, Microbiology and Molecular Genetics
University of California, Irvine

MBIDP Student Dissertation Defense
2021-01-26 14:00 - 16:00 | Zoom

Chao Peng, Ph.D.
2021-01-26 12:00 - 13:00 | Zoom
Chao Peng, Ph.D.
Assistant Professor, Neurology

Marie Kmita, Ph.D. | Hosted by Samantha Butler
2021-01-21 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Pioneering digit development”
Marie Kmita, Ph.D.
Research Unit Director
Laboratory of Genetics and Development
Institut de Recherches Cliniques de Montréal

Robert Schiestl, Ph.D.
2021-01-19 12:00 - 13:00 | Zoom
Robert Schiestl, Ph.D.
Professor, Pathology, Environmental Health Sciences, Radiation Oncology

Maxence Nachury, Ph.D. | Hosted by Daniel Velez-Ramirez and Kent Hill
2021-01-14 09:00 - 10:00 | Zoom
MBI Thursday Research Seminar

“Regulated trafficking of signaling receptors out of the primary cilium.”
Maxence Nachury, Ph.D.
Associate Professor, Ophthalmology
University of California, San Francisco

Mindful Movement with Raquel
2021-01-13 18:00 - 19:00 | Zoom
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Marlin Touma, M.D., Ph.D.
2021-01-12 12:00 - 13:00 | Zoom
Marlin Touma, M.D., Ph.D.
Assistant Professor-In-Residence, Pediatrics

All MBI Faculty Welcome

MBI Thursday Research Seminar
2021-01-07 09:00 - 10:00 | Zoom
“Molecular and cellular mechanisms regulating neuron-glial interactions”
Kelly Monk, Ph.D.
Senior Scientist and Co-Director
Vollum Institute, Oregon Health and Sciences University

Ahna R. Skop, Ph.D., D.Sc.
2020-12-17 09:00 - 10:00 | CA
“The midbody is a translationally active RNP granule necessary for intercellular communication”

Ahna R. Skop, Ph.D., D.Sc.
Professor, Genetics
University of Wisconsin-Madison

Scott Dehm, Ph.D.
2020-12-10 09:00 - 10:00 | CA
“Evolution and Plasticity of the Androgen Receptor in Prostate Cancer”
Scott Dehm, Ph.D.
Professor and Apogee Enterprises Chair in Cancer Research
Department of Laboratory Medicine and Pathology
University of Minnesota
Please email mbiasst@lifesci.ucla.edu for Zoom link.

MBI Faculty Seminar
2020-12-08 12:00 - 13:00 | Zoom
“Stronger than hunger was sorrow”: epigenetic consequences of glucose deprivation in lung cancer
Claudio Scafoglio, M.D., Ph.D.
Assistant Professor, Division of Pulmonary and Critical Care Medicine

Please email mbiasst@lifesci.ucla.edu for Zoom information.

All MBI Faculty Welcome
