Tsotne Chitiashvili
Research project:
Tsotne’s research focuses on Long non-coding RNA, XIST mediated molecular mechanisms of X chromosome regulation in human embryonic development. We study this epigenetic event in human pluripotent stem cells and human primordial germ cells.
Publications:
Chitiashvili T, Dror I, Kim R, Hsu F, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke Layland K, Plath K* and Clark A*. “Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation” Nature Cell Biology. Under revision.
Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Mancia W, Damianov A, Chronis C, Papp B, Chen C, McKee R, Wang X, Chau A, Leonhardt H, Zheng S, Guttman M, Black D. and Plath K. “An Fist-dependent protein assembly mediates Xist localization and gene silencing” Nature. accepted. Preprint bioRxiv 2020.03.09.979369
Guo J, Sosa E* & Chitiashvili T*, Nie X, Rojas E, Oliver E, Connect D, Kim R, Carrell D, Plath K, Hotaling J, Stukenborg J, Clark A* and Cairns B*. “Specification of Human Testis Somatic Lineages Precedes the Differentiation of the Fetal Germline” – Cell Stem Cell, Under revision.
Awards: