Tsotne Chitiashvili

Research project:

Tsotne’s research focuses on Long non-coding RNA, XIST mediated molecular mechanisms of X chromosome regulation in human embryonic development. We study this epigenetic event in human pluripotent stem cells and human primordial germ cells. 

 

Publications:

TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency – Tao Y, Yen MR, Chitiashvili T, Nakano H, Kim R, Hosohama L, Tan YC, Nakano A, Chen PY, and Clark AT. TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency. Stem Cell Reports. 2017. doi: 10.1016/j.stemcr.2017.11.020

Chitiashvili T, Dror I, Kim R, Hsu F, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke Layland K, Plath K* and Clark A*. “Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation” Nature Cell Biology. Under revision.

Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Mancia W, Damianov A, Chronis C, Papp B, Chen C, McKee R, Wang X, Chau A, Leonhardt H, Zheng S, Guttman M, Black D. and Plath K. “An Fist-dependent protein assembly mediates Xist localization and gene silencingNature. accepted. Preprint bioRxiv 2020.03.09.979369

Guo J, Sosa E* & Chitiashvili T*, Nie X, Rojas E, Oliver E, Connect D, Kim R, Carrell D, Plath K, Hotaling J, Stukenborg J, Clark A* and Cairns B*. “Specification of Human Testis Somatic Lineages Precedes the Differentiation of the Fetal Germline” – Cell Stem Cell, Under revision.   

Awards:

Boehringer Ingelheim PhD Fellowship: https://www.bifonds.de/fellowships-grants/phd-fellowships.html