Kevin Qian

Research project:

Kevin studies the functions of novel genes involved in adipose tissue metabolism and thermogenesis

Publications:

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability – Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR III, Yang X. Cell Metabolism. 2012, 16(2):226–37.

Protein O-GlcNAcylation: emerging mechanisms and functions – Yang X, Qian K. Nature Reviews Molecular Cell Biology. 2017, 18(7):452–465.

Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation – Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. Genes & Development. 2017, 31(16):1655–1665.

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA – Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Nature Medicine. 2018, 24(3):304–312.

Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer – Qian K, Wang S, Fu M, Zhou J, Singh JP, Li MD, Yang Y, Zhang K, Wu J, Nie Y, Ruan HB, Yang X. The Journal of Biological Chemistry. 2018, 293(36):13989-14000.

Yang X. O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth – Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR III, Han W, Sherwin RS, Nie Y. Oncogene. 2020, 39(3):560-573.

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Nature Medicine. 2018, 24(3):304–312.