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Xuchen Hu

Xuchen Hu

Home Area: Biochemistry, Biophysics, and Structural Biology
Mentor: Stephen Young
Research project:

Xuchen is understanding the role of GPIHBP1 in triglyceride metabolism and investigating the mechanism of cholesterol transport in macrophages.

Publications:

GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. J Clin Lipidol. 2017 Jun 13. pii: S1933-2874(17)30344-6. doi: 10.1016/j.jacl.2017.05.017. [Epub ahead of print]

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. N Engl J Med. 2017 Apr 27;376(17):1647-1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5.

High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2000-2005. doi: 10.1073/pnas.1621432114. Epub 2017 Feb 6.

Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15.

An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. J Lipid Res. 2016 Oct;57(10):1889-1898. Epub 2016 Aug 5.