Jaspreet Sandhu

Jaspreet Sandhu

Home Area: Gene Regulation, Epigenomics and Transcriptomics
Mentor: Peter Tontonoz
 Research project:

Jaspreet’s research focuses on Nuclear Receptors in Metabolism.

Publications:

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA – Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Nat Med. 2018 Mar;24(3):304-312. doi: 10.1038/nm.4479. Epub 2018 Feb 12. PubMed PMID: 29431742; PubMed Central PMCID: PMC5839972.

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure – Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. Cell. 2018 Jan 11;172(1-2):218-233.e17. doi: 10.1016/j.cell.2017.11.019. Epub 2017 Dec 14. PubMed PMID: 29249357; PubMed Central PMCID: PMC5766418.

Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function – Sallam T, Sandhu J, Tontonoz P. Long. Circ Res. 2018 Jan 5;122(1):155-166. doi: 10.1161/CIRCRESAHA.117.311802. Review. PubMed PMID: 29301847; PubMed Central PMCID: PMC5902384.

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP – Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. Elife. 2017 Oct 25;6. pii: e28766. doi: 10.7554/eLife.28766. PubMed PMID: 29068315; PubMed Central PMCID: PMC5656429.

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2 – Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. Cell Rep. 2016 Nov 1;17(6):1671-1682. doi: 10.1016/j.celrep.2016.10.023.

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis – Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. Nature. 2016 May 11;534(7605):124-8. doi: 10.1038/nature17674.

CMF22 is a broadly conserved axonemal protein and is required for propulsive motility in Trypanosoma brucei – Nguyen HT, Sandhu J, Langousis G, Hill KL. Eukaryot Cell 2013 Sep;12(9):1202-13. doi: 10.1128/EC.00068-13. Epub 2013 Jul 12. PubMed PMID: 23851336; PubMed Central PMCID: PMC3811564.