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David Gray

David Gray

Home Area: Immunity, Microbes, and Molecular Pathogenesis
Mentor: Donald Kohn
Research project:

David is researching gene therapy for the treatment of primary immunodeficiencies. His project focuses on CRISPR/Cas9 mediated gene editing for therapeutic treatment of X-Linked Agammaglobulinemia.

Publications:

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells. Hoban MD, Cost GJ, Mendel MC, Romero Z, Kaufman ML, Joglekar AV, Ho M, Lumaquin D, Gray D, Lill GR, Cooper AR, Urbinati F, Senadheera S, Zhu A, Liu PQ, Paschon DE, Zhang L, Rebar EJ, Wilber A, Wang X, Gregory PD, Holmes MC, Reik A, Hollis RP, Kohn DB. Blood. 2015 Apr 23;125(17):2597-604. doi: 10.1182/blood-2014-12-615948. Epub 2015 Mar 2.