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Anna Sahakyan

Anna Sahakyan

Home Area: Cell and Developmental Biology
Mentor: Kathrin Plath
Research project:

Anna studies the process of X chromosome inactivation in human cells, particularly how the long non-coding RNA XIST induces chromosome-wide silencing upon differentiation of female pluripotent cells.

Publications:

Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation. Sahakyan A, Kim R, Chronis C, Sabri S, Bonora G, Theunissen TW, Kuoy E, Langerman J, Clark AT, Jaenisch R, Plath K. Cell Stem Cell. 2017 Jan 5;20(1):87-101. doi: 10.1016/j.stem.2016.10.006. Epub 2016 Dec 15

Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation. Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJ, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K. Cell Rep. 2017 Jan 3;18(1):54-67. doi: 10.1016/j.celrep.2016.11.054. Epub 2016 Dec 16.

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. Cell Stem Cell. 2016 Sep 3. pii: S1934-5909(16)30255-7. doi: 10.1016/j.stem.2016.08.008. [Epub ahead of print]

Transcriptome Encyclopedia of Early Human Development. Sahakyan A, Plath K. Cell. 2016 May 5;165(4):777-9. doi: 10.1016/j.cell.2016.04.042.

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory. Pastor WA, Chen D, Liu W, Kim R, Sahakyan A, Lukianchikov A, Plath K, Jacobsen SE, Clark AT. Cell Stem Cell. 2016 Mar 3;18(3):323-9. doi: 10.1016/j.stem.2016.01.019. Epub 2016 Feb 4.

A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2′-dC upon inhibition of ribonucleotide reductase. Minkovsky A, Sahakyan A, Bonora G, Damoiseaux R, Dimitrova E, Rubbi L, Pellegrini M, Radu CG, Plath K. Epigenetics Chromatin. 2015 Oct 13;8:42. doi: 10.1186/s13072-015-0034-4. eCollection 2015

The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. Minkovsky A, Sahakyan A, Rankin-Gee E, Bonora G, Patel S, Plath K. Epigenetics Chromatin. 2014 Jun 26;7:12. doi: 10.1186/1756-8935-7-12. eCollection 2014.