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This image represents the total view of modern biology (ca. 1989) including a model organism (Drosophila), cells (the photoreceptor), molecules (visual pigments; and the membrane protein rhodopsin in its native environment) and recombinant DNA technology (the expression vector). It was painted by Ruben Di Anda, a San Diego artist, based on a design by David Meyer (MBI member). |
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Suraj P. Bhat Laboratory Title: Non-Crystallin functions of Crystallins: Top:
Confocal
images of U373 glioblastoma synchronized cultures showing co-localization
of ?B-crystallin (red) and GM130 (a Golgi matrix protein) (green)
in the perinuclear Golgi. |
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Ellen Carpenter Laboratory Mouse
spinal cord at day 11 of gestation labeled with anti-neurofilament
antibodies. All developing fiber tracts are visible at this age. |
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Eddy DeRobertis Laboratory Two
signaling centers present in the blastula-stage Xenopus embryo.
An early b-catenin signal on the dorsal side induces the blastula
Chordin- and Noggin-expressing (BCNE) center (in green) and the
Nieuwkoop center (black). Transplanted BCNE center cells give rise
to the brain, shown in the 6-day tadpole on the right by grafting
transgenic cells marked with green fluorescent protein. |
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Juli Feigon Laboratory The cover shows the solution structure of the conserved pseudoknot in the core domain of human telomerase RNA, rendered as bonds covered by a molecular surface (colored by structural element). Three minor groove base triples, a junction loop-loop Hoogsteen base pair, and two major groove base triples (shown above the structure and as background) form an extended triple helix that stabilizes the pseudoknot structure. Mutations that disrupt the tertiary interactions affect telomerase activity. For more details, see the article by Theimer et al., pp. 671–682, in the March 4, 2005 issue of Molecular Cell. |
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Michael Grunstein Laboratory A
novel site of acetylation at the entry-exit points of the nucleosomal
DNA superhelix regulates gene activity. |
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Michael Grunstein Laboratory Histone acetylation patterns in the yeast genome. |
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Kent Hill Laboratory Trypanosoma brucei expressing GFP on its surface. |
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Kent Hill Laboratory Trypanosoma brucei expressing cytoplasmic GFP. |
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Kent Hill Laboratory It’s all about the questions. Trypanosoma brucei expressing GFP in its flagellum. |
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Ronald Kaback Laboratory Overall structure of LacY with bound substrate, ?-D-galactopyranosyl-1-thio-?-D-galactospyranoside (TDG). (A) Viewed parallel to the membrane. (B) Viewed along the membrane normal from the cytoplasmic side. Connecting loops have been omitted. |
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Siavash K. Kurdistani Laboratory |
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Siavash K. Kurdistani Laboratory |
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Jake Lusis Laboratory This
is a view
of a co-expression network we have generatedcin our lab. |
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Sabeeha Merchant Laboratory |
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Stan Nelson Laboratory Sequence analysis is critically important to the delineation of the genetic causes of various human diseases. Array based sequencing using Affymetrix 25mer probes provides a powerful means to simultaneously sequence many genes simultaneously using hybridization. A portion of a 30,000 bp resequencing array is shown which allows robust sequence determination and the de novo detection of heterozygous positions. |
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Stan Nelson Laboratory Color coding of linkage disequilibrium between polymorphic markers revealing block like structure of linkage disequilibrium adjacent to the NF1 gene on chromosome 17: J. Stone, Nelson Lab |
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Stan
Nelson Laboratory Large scale expression arrays are widely used to probe the response of the genome to perturbations. Z. Chen, Nelson Lab |
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Stan Nelson Laboratory Whole genome expression data can be organized to reveal gene-gene relationships. Here the gene expression pattern for receptor tyrosine kinases are grouped by hierarchical clustering. REd indicates relatively higher expression, blue relatively lower expression and white is average expression for a series of normal human tissues. M Carlson, Nelson Lab |
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Stan Nelson Laboratory Shape encoding provides a powerful means to encode information and affiliate with biological materials like DNA for the creation of complex assays. Here a panel of 400 of 300,000 possible different shapes are drawn. |
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Stan Nelson Laboratory Whole
genome co-expression networks reveal unknown |
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Michael Sawaya Laboratory Cross
beta spine of the amyloid-like fibril, GNNQQNY, isolated from the
yeast prion, sup35. The structure was determined at atomic resolution
in the Eisenberg lab. Light is focused on the portion of the structure
termed the steric zipper. An electron micrograph of GNNQQNY fibers
are shown in the background. |
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J. William Schopf Laboratory Optical photomicrographs (color) and laser-Raman images (black and white) of microfossils three-dimensionally permineralized (petrified) in ancient cherts. Upper left: the acanthomorph acritarch Multiplicisphaeridium (~75 microns across, including appendages) from the Lower Devonian (~400-Ma-old) Kalkberg Limestone of New York, USA. Upper right: the multilayered tube-like stalk of the pleurocapsacean cyanobacterium Polybessurus (~180 microns in diameter) from the Precambrian (~775-Ma-old) River Wakefield Subgroup of South Australia. Bottom: the cylindrical sheath of a Lyngbya-like cyanobacterium (~20 microns in diameter) from the Precambrian (~650-Ma-old) Chichkan Formation of southern Kazakhstan. Raman imagery, a technique new to paleobiology documented by Schopf et al. in this issue, permits direct correlation of the molecular-structural composition and the optically discernable morphology of such rock-embedded fossils, showing them to be composed of carbonaceous kerogen. (Illustration by A.D. Czaja, A.B. Kudryavtsev, and J.W. Schopf, University of California, Los Angeles)
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X. William Yang Laboratory Using a conditional mouse model of Huntington’s Disease (HD), Dr. X. William Yang’s laboratory provided the first genetic evidence that pathological cell-cell interactions are critical to cortical pathogenesis in HD mice (Gu et al, Neuron 46: 433, 2005). The background image is an electron microscopic picture of the HD mouse cortex with dark degenerating neurons. The illustration in the center shows the pathological cortical neuronal circuitry in HD mice consisting of an inhibitory interneuron (in blue) and a pyramidal neuron (in orange). |
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Todd O. Yeates and David Eisenberg Laboratories "Diagrams illustrating the application of logic analysis to phylogenetic profile data. The method shown allows for the identification of previously unknown functional linkages between triplets of proteins whose profiles across many known genomes satisfy certain logic relationships. Logic Analysis of Phylogenetic Profiles was developed by Peter Bowers and Shawn Cokus in the Yeates and Eisenberg Laboratories. (Bowers, P.M., et al. (2004). Science 306, 2246-9.)" |
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Todd Yeates Laboratory "An illustration of the protein structures that make up the shell of the enigmatic bacterial microcompartment. These giant subcellular shells, reminiscent of viral capsids, are used by many bacteria as primitive organelles inside which certain enzymes are encapsulated in order to perform special chemical reactions in a sequestered environment. These first structures are of the CO2-fixing microcompartment called the carboxysome. Protein structures were determined in the Yeates laboratory by Cheryl Kerfeld, Michael Sawaya, Shiho Tanaka, and Morgan Beeby." |